Neural induction: toward a unifying mechanism

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1998 • 1,587 citations

Fibroblast growth factors, their receptors and signaling.

2000 • 1,303 citations

Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity

2000 • 1,267 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

1998 • 838 citations

über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren

1924 • 817 citations

Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation

1996 • 789 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

1989 • 652 citations

WNTs modulate cell fate and behavior during vertebrate development

1997 • 604 citations

Multiple defects and perinatal death in mice deficient in follistatin

1995 • 586 citations

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

1996 • 548 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

The organizer factors Chordin and Noggin are required for mouse forebrain development

2000 • 528 citations

Initiation of neural induction by FGF signalling before gastrulation

2000 • 519 citations

T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification

1999 • 510 citations

The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

2000 • 462 citations

Ectodermal Patterning in Vertebrate Embryos

1997 • 457 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

Ventral and Lateral Regions of the Zebrafish Gastrula, Including the Neural Crest Progenitors, Are Established by abmp2b/swirlPathway of Genes

1998 • 424 citations

Induction of a second neural axis by the mouse node

1994 • 420 citations

On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.

1994 • 396 citations

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

1995 • 390 citations

Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.

1995 • 368 citations

Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1

1997 • 354 citations

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

1997 • 351 citations

Biochemical characterization of Wnt-Frizzled interactions using a soluble, biologically active vertebrate Wnt protein

1999 • 351 citations

Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo

1998 • 350 citations

Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP‐2 and BMP‐4

1995 • 344 citations

III. Experiments on the development of chick and duck embryos, cultivatedin vitro

1932 • 339 citations

Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development

1999 • 338 citations

An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo

2000 • 326 citations

Activation and organization of the central nervous system in amphibians. Part I. Induction and activation

1952 • 319 citations

The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

2001 • 315 citations

Induction of Embryonic Primordia by Implantation of Organizers from a Different Species

2024 • 311 citations

Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4

1997 • 311 citations

Cooperation of BMP7 and SHH in the Induction of Forebrain Ventral Midline Cells by Prechordal Mesoderm

1997 • 292 citations

Establishment of the Dorsal–Ventral Axis inXenopus Embryos Coincides with the Dorsal Enrichment of Dishevelled That Is Dependent on Cortical Rotation

1999 • 255 citations

Neural induction and regionalisation in the chick embryo

1992 • 250 citations

Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps.

1996 • 248 citations

Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo.

1987 • 247 citations

Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity

1999 • 236 citations

Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer

1989 • 232 citations

Kinematics of gray crescent formation in Xenopus eggs: The displacement of subcortical cytoplasm relative to the egg surface

1986 • 230 citations

Neural induction

2000 • 224 citations

Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage

1996 • 224 citations

Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation

1998 • 222 citations

Notochordal induction of cell wedging in the chick neural plate and its role in neural tube formation

1989 • 218 citations

Initial patterning of the central nervous system: How many organizers?

2001 • 217 citations

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.

1996 • 213 citations

Visceral Endoderm Mediates Forebrain Development by Suppressing Posteriorizing Signals

2000 • 213 citations

bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus

1995 • 203 citations

Head in the WNT: the molecular nature of Spemann’s head organizer

1999 • 202 citations

Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo

2000 • 202 citations

A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers

1996 • 198 citations

The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo

1999 • 193 citations

Characterization and early embryonic expression of a neural specific transcription factor xSOX3 in Xenopus laevis.

1997 • 181 citations

Activation and organization of the central nervous system in amphibians. Part III. Synthesis of a new working hypothesis

1952 • 180 citations

BMP signalling in early Xenopus development

1999 • 171 citations

Induction by the Primitive Streak and its Derivatives in the Chick

1933 • 167 citations

VERTEBRATE NEURAL INDUCTION

1997 • 162 citations

Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3

1997 • 158 citations

Convergent Inductive Signals Specify Midbrain, Hindbrain, and Spinal Cord Identity in Gastrula Stage Chick Embryos

1999 • 156 citations

FGF Signaling and the Anterior Neural Induction in Xenopus

1999 • 146 citations

Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast

2000 • 146 citations

Ectodermal patterning in the avian embryo: epidermis versus neural plate

1999 • 137 citations

Vertebrate Neural Induction: Inducers, Inhibitors, and a New Synthesis

1997 • 131 citations

SoxD

1998 • 130 citations

A Dominant Negative Bone Morphogenetic Protein 4 Receptor Causes Neuralization in Xenopus Ectoderm

1995 • 127 citations

Neural Induction in the Absence of Mesoderm: β-Catenin-Dependent Expression of Secreted BMP Antagonists at the Blastula Stage in Xenopus

2001 • 126 citations

A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1

2000 • 116 citations

Induction of the mammalian node requires Arkadia function in the extraembryonic lineages

2001 • 110 citations

Head induction in the chick by primitive endoderm of mammalian, but not avian origin

1999 • 108 citations

Neural Induction and Patterning in the Mouse in the Absence of the Node and Its Derivatives

1999 • 107 citations

The role of the dorsal lip in the induction of heart mesoderm in Xenopus laevis

1990 • 106 citations

Assignment of Early Caudal Identity to Neural Plate Cells by a Signal from Caudal Paraxial Mesoderm

1997 • 106 citations

The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways

2000 • 105 citations

FGF Is Required for Posterior Neural Patterning but Not for Neural Induction

1999 • 104 citations

Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase

1995 • 100 citations

Hensen’s node induces neural tissue in Xenopus ectoderm. Implications for the action of the organizer in neural induction

1991 • 98 citations

Neural induction: a bird's eye view

1999 • 97 citations

Gata2 and Gata3: novel markers for early embryonic polarity and for non-neural ectoderm in the chick embryo

1999 • 92 citations

Ras-Mediated FGF Signaling Is Required for the Formation of Posterior but Not Anterior Neural Tissue in Xenopus laevis

2000 • 91 citations

Impact of Node Ablation on the Morphogenesis of the Body Axis and the Lateral Asymmetry of the Mouse Embryo during Early Organogenesis

1999 • 83 citations

Chick noggin is expressed in the organizer and neural plate during axial development, but offers no evidence of involvement in primary axis formation.

1997 • 82 citations

eFGF is expressed in the dorsal midline of Xenopus laevis.

1995 • 81 citations

Early anteroposterior division of the presumptive neurectoderm in Xenopus

2001 • 72 citations

Nodal signaling and the zebrafish organizer.

2001 • 68 citations

Signaling specificities of fibroblast growth factor receptors in early Xenopus embryo

2000 • 57 citations

Anterior Neural Induction by Nodes from Rabbits and Mice

2000 • 43 citations

Visualization of endogenous BMP signaling during Xenopus development

2001 • 42 citations

The roles of activin and follistatin signaling in chick gastrulation.

1998 • 36 citations

Xenopus crescent encoding a Frizzled-like domain is expressed in the Spemann organizer and pronephros

2000 • 32 citations

Regional specification of motoneurons along the anterior-posterior axis is independent of the notochord

1996 • 26 citations

Evidence that the border of the neural plate may be positioned by the interaction between signals that induce ventral and dorsal mesoderm

1993 • 22 citations

The molecular nature of Spemann's head organizer

1999 • 6 citations