Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Patterning the Vertebrate Neuraxis

1996 • 1,151 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

1995 • 1,060 citations

From cleavage to primitive streak formation: A complementary normal table and a new look at the first stages of the development of the chick

1976 • 898 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

A common plan for dorsoventral patterning in Bilateria

1996 • 774 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

Diversity and Pattern in the Developing Spinal Cord

1996 • 714 citations

A role for bone morphogenetic proteins in the induction of cardiac myogenesis.

1997 • 687 citations

Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

1992 • 573 citations

A New Technique for the Cultivation of the Chick Embryo in vitro

1955 • 530 citations

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning

1997 • 518 citations

DVR-4 (Bone Morphogenetic Protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction

1992 • 488 citations

A comparison of the properties ofSox-3withSryand two related genes,Sox-1andSox-2

1996 • 485 citations

Ectodermal Patterning in Vertebrate Embryos

1997 • 457 citations

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

1994 • 449 citations

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin

1995 • 436 citations

On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.

1994 • 396 citations

Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development

1995 • 388 citations

The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4

1997 • 382 citations

Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.

1995 • 368 citations

Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm

1993 • 365 citations

Vertebrate Embryonic Cells Will Become Nerve Cells Unless Told Otherwise

1997 • 348 citations

Ventral mesodermal patterning in Xenopus embryos: Expression patterns and activities of BMP‐2 and BMP‐4

1995 • 344 citations

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

1994 • 307 citations

The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm

1993 • 292 citations

Neural induction and regionalisation in the chick embryo

1992 • 250 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

A fate map of the epiblast of the early chick embryo

1994 • 232 citations

Localized BMP-4 Mediates Dorsal/Ventral Patterning in the Early Xenopus Embryo

1995 • 229 citations

Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick

1990 • 213 citations

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.

1996 • 213 citations

c-otx2 is expressed in two different phases of gastrulation and is sensitive to retinoic acid treatment in chick embryo

1995 • 197 citations

Mesodermal subdivision along the mediolateral axis in chicken controlled by different concentrations of BMP-4

1997 • 183 citations

The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm.

1996 • 178 citations

Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2

1997 • 162 citations

Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.

1995 • 161 citations

Regulation of dorsal-ventral patterning: the ventralizing effects of the novel Xenopus homeobox gene Vox

1996 • 158 citations

THE CULTIVATION OF TISSUES IN SALINE EMBRYONIC JUICE.

1924 • 143 citations

Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos

1996 • 143 citations

The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA.

1995 • 137 citations

An integrated experimental study of endoderm formation in avian embryos

1981 • 136 citations

Vertebrate Neural Induction: Inducers, Inhibitors, and a New Synthesis

1997 • 131 citations

A Dominant Negative Bone Morphogenetic Protein 4 Receptor Causes Neuralization in Xenopus Ectoderm

1995 • 127 citations

Fish are like flies are like frogs: Conservation of dorsal‐ventral patterning mechanisms

1997 • 123 citations

The marginal zone and its contribution to the hypoblast and primitive streak of the chick embryo

1990 • 120 citations

Early Stages of Notochord and Floor Plate Development in the Chick Embryo Defined by Normal and Induced Expression of HNF-3β

1995 • 119 citations

Misexpression of chick Vg1 in the marginal zone induces primitive streak formation

1997 • 117 citations

Conservation of dorsal-ventral patterning in arthropods and chordates

1996 • 116 citations

Mechanisms of dorsal-ventral patterning in noggin-induced neural tissue

1997 • 107 citations

Early developmental expression and experimental axis determination by the chicken Vg1 gene

1996 • 107 citations

A role for HGF/SF in neural induction and its expression in Hensen’s node during gastrulation

1995 • 106 citations

A role for BMP-4 in the development of subcutaneous cartilage

1996 • 97 citations

The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development

1996 • 93 citations

Skeletal Myogenesis: The Preferred Pathway of Chick Embryo Epiblast Cellsin Vitro

1996 • 90 citations

The prechordal region lacks neural inducing ability, but can confer anterior character to more posterior neuroepithelium

1997 • 87 citations

Expression of HGF/SF, HGFI/MSP, and c‐met suggests new functions during early chick development

1995 • 86 citations

Neural induction in Xenopus laevis: evidence for the default model

1997 • 83 citations

Chick noggin is expressed in the organizer and neural plate during axial development, but offers no evidence of involvement in primary axis formation.

1997 • 82 citations

The chick's marginal zone and primitive streak formation

1989 • 80 citations

The chick's marginal zone and primitive streak formation

1989 • 67 citations

Cloning, sequencing, and expressional analysis of the chick homologue of follistatin

1995 • 53 citations

Rauber's (Koller's) sickle: the early gastrulation organizer of the avian blastoderm.

1994 • 52 citations

The Initiation of Gastrular Ingression in the Chick Blastoderm

1984 • 33 citations

Experimental control of axial pattern in the chick blastoderm by local expression of Wnt and activin: The role of HNK-1 positive cells

1994 • 29 citations

Mesoderm Formation in the Chick Embryo, Revisited

1991 • 13 citations

Inductions par le noeud postérieur de la ligne primitive des oiseaux

1973 • 5 citations

[Inductions by the nodus posterior of the primitive streak of birds].

1973 • 4 citations