Neural Induction and Patterning in the Mouse in the Absence of the Node and Its Derivatives

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1998 • 1,587 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Requirement for Wnt3 in vertebrate axis formation

1999 • 882 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Clonal analysis of epiblast fate during germ layer formation in the mouse embryo

1991 • 865 citations

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

1998 • 838 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

1999 • 823 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

1991 • 730 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development

1995 • 662 citations

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

1999 • 644 citations

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

1993 • 619 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Mouse gastrulation: the formation of a mammalian body plan

1997 • 595 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope

1993 • 577 citations

Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

1989 • 566 citations

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

1996 • 548 citations

Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse

1989 • 511 citations

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

1993 • 505 citations

Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo

1992 • 467 citations

Ectodermal Patterning in Vertebrate Embryos

1997 • 457 citations

Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development

1995 • 424 citations

Induction of a second neural axis by the mouse node

1994 • 420 citations

Telencephalon-restricted expression of BF-1, a new member of the HNF-3/ fork head gene family, in the developing rat brain

1992 • 417 citations

Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system

1993 • 417 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Gastrulation in the mouse: The role of the homeobox gene goosecoid

1992 • 378 citations

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

1997 • 351 citations

Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo

1998 • 350 citations

Vertebrate Embryonic Cells Will Become Nerve Cells Unless Told Otherwise

1997 • 348 citations

The transcription factor HNF3β is required in visceral endoderm for normal primitive streak morphogenesis

1998 • 335 citations

Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants

1994 • 333 citations

Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis

1992 • 332 citations

Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm

1990 • 300 citations

Anterior patterning in mouse

1998 • 287 citations

A Mouse Cerberus/Dan-Related Gene Family

1999 • 283 citations

Patterning the vertebrate head: murine Hox 2 genes mark distinct subpopulations of premigratory and migrating cranial neural crest

1991 • 246 citations

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.

1988 • 225 citations

Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage

1996 • 224 citations

Expression of Pax-3 in the Lateral Neural Plate Is Dependent on a Wnt-Mediated Signal from Posterior Nonaxial Mesoderm

1999 • 195 citations

mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation

1991 • 189 citations

A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung.

1992 • 189 citations

The vertebrate organizer: structure and molecules

1996 • 173 citations

Anterior mesendoderm induces mouse Engrailed genes in explant cultures

1993 • 164 citations

Basic FGF as an inducer of anteroposterior neural pattern

1995 • 145 citations

The role of the notochord and floor plate in inductive interactions

1995 • 139 citations

Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain

1994 • 126 citations

Restoration of the organizer after radical ablation of Hensen’s node and the anterior primitive streak in the chick embryo

1996 • 112 citations

BMP-7 influences pattern and growth of the developing hindbrain of mouse embryos

1997 • 108 citations

Molecular mechanisms of vertebrate left–right development

1998 • 107 citations

Two enhancer regions in the mouse En-2 locus direct expression to the mid/hindbrain region and mandibular myoblasts

1993 • 97 citations

The patterning and functioning of protrusive activity during convergence and extension of the Xenopus organiser

1992 • 93 citations

Impact of Node Ablation on the Morphogenesis of the Body Axis and the Lateral Asymmetry of the Mouse Embryo during Early Organogenesis

1999 • 83 citations

Characterization of a gene trap insertion into a novel gene, cordon‐bleu, expressed in axial structures of the gastrulating mouse embryo

1995 • 68 citations

The When and Where of Floor Plate Induction

1998 • 66 citations

Identification of Inducing, Responding, and Suppressing Regions in an Experimental Model of Notochord Formation in Avian Embryos

1995 • 41 citations