Head in the WNT: the molecular nature of Spemann’s head organizer

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

Hudson et al.

1977 • 2,560 citations

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1998 • 1,587 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER

1997 • 836 citations

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

1999 • 823 citations

über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren

1924 • 817 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

1997 • 725 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

The Xenopus Dorsalizing Factor Gremlin Identifies a Novel Family of Secreted Proteins that Antagonize BMP Activities

1998 • 649 citations

WNTs modulate cell fate and behavior during vertebrate development

1997 • 604 citations

Vital dye mapping of the gastrula and neurula of Xenopus laevis

1976 • 576 citations

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

1997 • 573 citations

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

1996 • 548 citations

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

1989 • 518 citations

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

1997 • 508 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

1997 • 493 citations

Ectodermal Patterning in Vertebrate Embryos

1997 • 457 citations

Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula

1997 • 452 citations

Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.

1993 • 449 citations

über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren

1924 • 429 citations

Induction of a second neural axis by the mouse node

1994 • 420 citations

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation

1997 • 384 citations

The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail

1997 • 354 citations

Xsox17α and -β Mediate Endoderm Formation in Xenopus

1997 • 354 citations

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

1997 • 351 citations

Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo

1998 • 350 citations

Vertebrate Embryonic Cells Will Become Nerve Cells Unless Told Otherwise

1997 • 348 citations

Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.

1996 • 345 citations

�ber die Induktionsf�higkeit der verschiedenen Bezirke der Neurula von Urodelen

1933 • 301 citations

Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a

1997 • 300 citations

Anterior patterning in mouse

1998 • 287 citations

Neural induction and regionalisation in the chick embryo

1992 • 250 citations

An inductive role for the endoderm in Xenopus cardiogenesis

1995 • 234 citations

A small population of anterior cells patterns the forebrain during zebrafish gastrulation

1998 • 232 citations

Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage

1996 • 224 citations

Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus

1997 • 224 citations

Specification of the Anteroposterior Neural Axis through Synergistic Interaction of the Wnt Signaling Cascade withnogginandfollistatin

1995 • 222 citations

Patterning of the chick forebrain anlage by the prechordal plate

1997 • 207 citations

Mixer , a Homeobox Gene Required for Endoderm Development

1998 • 206 citations

Overlapping Expression of Xwnt-3A and Xwnt-1 in Neural Tissue of Xenopus laevis Embryos

1993 • 202 citations

Murine Cerberus Homologue mCer-1: A Candidate Anterior Patterning Molecule

1998 • 185 citations

Mechanism of anteroposterior axis specification in vertebrates Lessons from the amphibians

1992 • 179 citations

Neural Crest Induction by Xwnt7B in Xenopus

1998 • 175 citations

Anterior mesendoderm induces mouse Engrailed genes in explant cultures

1993 • 164 citations

Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm

1997 • 145 citations

The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number

1997 • 143 citations

Determination of the zebrafish forebrain: induction and patterning

1998 • 130 citations

Wnt signaling: why is everything so negative?

1998 • 112 citations

Frzb-1, an Antagonist of Wnt-1 and Wnt-8, Does Not Block Signaling by Wnts -3A, -5A, or -11

1997 • 111 citations

Head induction in the chick by primitive endoderm of mammalian, but not avian origin

1999 • 108 citations

Blastomere derivation and domains of gene expression in the Spemann Organizer of Xenopus laevis

1995 • 105 citations

Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase

1995 • 100 citations

Xwnt-8 and lithium can act upon either dorsal mesodermal or neurectodermal cells to cause a loss of forebrain in Xenopus embryos

1997 • 89 citations

The prechordal region lacks neural inducing ability, but can confer anterior character to more posterior neuroepithelium

1997 • 87 citations

The Spemann Organizer ofXenopusIs Patterned along Its Anteroposterior Axis at the Earliest Gastrula Stage

1997 • 84 citations

Chick noggin is expressed in the organizer and neural plate during axial development, but offers no evidence of involvement in primary axis formation.

1997 • 82 citations

BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation

1998 • 75 citations

Vertebrate head induction by anterior primitive endoderm

1997 • 74 citations

Positive and negative signals modulate formation of the Xenopus cement gland

1996 • 69 citations

Induction of anteroposterior neural pattern in Xenopus by planar signals

1992 • 42 citations

Homeogenetic neural induction in xenopus

1991 • 42 citations

Activation and organization of the central nervous system in amphibians. Part II. Differentiation and organization

1952 • 40 citations

Observations sur la localisation de la plaque préchordale et de l'entoblaste présomptifs au cours de la gastrulation chez Xenopus laevis

1949 • 5 citations