P ‐450 Cytochromes: Structure and Function

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

Synthesis and Processing of Asparagine-Linked Oligosaccharides

1981 • 1,403 citations

[47] Establishing homologies in protein sequences

1983 • 1,187 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Ferricytochrome c

1971 • 879 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.

1985 • 815 citations

Polycyclic Hydrocarbons and Cancer

1981 • 737 citations

Multiple Mechanisms of Protein Insertion into and Across Membranes

1985 • 720 citations

A New Cytochrome in Liver Microsomes

1962 • 658 citations

Pigments of rat liver microsomes

1958 • 634 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 • 576 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

1978 • 531 citations

Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

1974 • 518 citations

Phosphatidylcholine Requirement in the Enzymatic Reduction of Hemoprotein P-450 and in Fatty Acid, Hydrocarbon, and Drug Hydroxylation

1970 • 462 citations

Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms.

1975 • 456 citations

Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions

1958 • 433 citations

Correlation of sequence hydrophobicities measures similarity in three-dimensional protein structure

1983 • 401 citations

The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen.

1957 • 399 citations

A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.

1980 • 358 citations

Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states.

1978 • 346 citations

Properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

1973 • 344 citations

Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450

1976 • 339 citations

Enzymatic activation of chemicals to toxic metabolites

1985 • 331 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction.

1984 • 324 citations

[17] Bacterial P-450cam methylene monooxygenase components: Cytochrome m, putidaredoxin, and putidaredoxin reductase

1978 • 317 citations

Conjugation Reactions in Drug Biotransformation

1980 • 314 citations

Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.

1985 • 311 citations

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

1985 • 301 citations

Genetic Mechanisms Controlling the Induction of Polysubstrate Monooxygenase (P-450) Activities

1981 • 296 citations

Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase.

1981 • 295 citations

Microsomal cytochrome P-450 from neonatal pig testis: two enzymic activities (17.alpha.-hydroxalase and C17,20 associated with one protein

1981 • 291 citations

Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.

1980 • 286 citations

TRIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME c REDUCTASE IN LIVER

1950 • 280 citations

Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver.

1982 • 275 citations

Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.

1980 • 256 citations

Spectroscopic investigations of ferric cytochrome P-450-CAM ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme.

1982 • 256 citations

Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats

1978 • 255 citations

Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols.

1982 • 235 citations

Human Dioxin-Inducible Cytochrome P ₁ -450: Complementary DNA and Amino Acid Sequence

1985 • 233 citations

Sex difference of cytochrome P-450 in the rat: Purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats

1983 • 233 citations

Genes for Cytochrome P-450 and Their Regulatio

1986 • 227 citations

Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system.

1980 • 224 citations

Mitochondria and Microsomes

1982 • 223 citations

Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms.

1982 • 221 citations

Purification and characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls

1982 • 217 citations

C21 steroid side chain cleavage enzyme from porcine adrenal microsomes. Purification and characterization of the 17 alpha-hydroxylase/C17,20-lyase cytochrome P-450.

1984 • 212 citations

Isolation and purification of cytochrome P-450, and the existence of multiple forms

1979 • 210 citations

Multiple forms of hepatic cytochrome P-450. Purification, characterisation and comparison of a novel clofibrate-induced isozyme with other major forms of cytochrome P-450

1984 • 210 citations

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

1984 • 208 citations

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

1984 • 199 citations

Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme.

1985 • 194 citations

Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines

1973 • 193 citations

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

1983 • 192 citations

Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450

1977 • 187 citations

The catalytic mechanism of cytochrome P-450. Spin-trapping evidence for one-electron substrate oxidation.

1982 • 182 citations

Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family.

1985 • 181 citations

Origin of the anomalous Soret spectra of carboxycytochrome P-450

1976 • 180 citations

Cytochrome P-450: Localization in Rabbit Lung

1980 • 179 citations

Cytochrome P450 as an oxene transferase

1976 • 176 citations

Structural features of liver microsomal NADPH-cytochrome P-450 reductase. Hydrophobic domain, hydrophilic domain, and connecting region.

1982 • 173 citations

Coding nucleotide sequence of rat NADPH-cytochrome P-450 oxidoreductase cDNA and identification of flavin-binding domains.

1985 • 171 citations

Studies on the steroid hydroxylation system in adrenal cortex microsomes. Purification and characterization of cytochrome P-450 specific for steroid C-21 hydroxylation.

1980 • 171 citations

Sodium periodate, sodium chlorite, organic hydroperoxides, and H2O2 as hydroxylating agents in steroid hydroxylation reactions catalyzed by partially purified cytochrome P-450

1975 • 168 citations

Structural gene products of the Ah locus. Genetic and immunochemical evidence for two forms of mouse liver cytochrome P-450 induced by 3-methylcholanthrene.

1979 • 166 citations

Separation, purification, and properties of multiple forms of cytochrome P-450 from the liver microsomes of phenobarbital-treated mice.

1976 • 159 citations

Purification and characterization of two constitutive forms of rat liver microsomal cytochrome P-450.

1982 • 156 citations

An aryl hydrocarbon hydroxylating hepatic cytochrome P-450 from the marine fish Stenotomus chrysops

1983 • 155 citations

Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholanthrene.

1979 • 153 citations

[10] Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450lm4 (rabbit liver)

1978 • 151 citations

Gene structure of a major form of phenobarbital-inducible cytochrome P-450 in rat liver.

1985 • 150 citations

Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism

1984 • 150 citations

Conversion of P-450 to P-420 by neutral salts and some other reagents.

1967 • 150 citations

Resonance Raman detection of an iron-sulfur bond in cytochrome P 450cam

1982 • 150 citations

Structural Characteristics of Cytochrome P-450. Possible Location of the Heme-Binding Cysteine in Determined Amino-Acid Sequences

1983 • 146 citations

Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes.

1983 • 146 citations

Functional differences between peroxidase compound I and the cytochrome P-450 reactive oxygen intermediate.

1983 • 146 citations

Superoxide anion production by the autoxidation of cytochrome P450cam

1974 • 139 citations

The cytochrome P-450 active site. Regiospecificity of prosthetic heme alkylation by olefins and acetylenes.

1983 • 138 citations

Cytochrome P-450-Dependent Monooxygenases in Olfactory Epithelium of Dogs: Possible Role in Tumorigenicity

1982 • 136 citations

Purification and immunochemical characterization of the two adrenal cortex mitochondrial cytochrome P-450-proteins

1978 • 136 citations

Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.

1983 • 133 citations

Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5

1983 • 132 citations

Conversion of P-450 to P-420 by Neutral Salts and some other Reagents

1967 • 132 citations

The Role of NADH in Uncoupled Microsomal Monoxygenations

1974 • 131 citations

Benzo[a]pyrene-hydroxylase catalyzed by purified isozymes of cytochrome P-450 from β-naphthoflavone-fed rainbow trout

1984 • 131 citations

Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat.

1984 • 130 citations

Pseudomonas putida cytochrome P-450: Characterization of an oxygenated form of the hemoprotein

1972 • 130 citations

Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver.

1984 • 129 citations

Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC

1984 • 129 citations

Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties.

1984 • 127 citations

Hydroxylations in biosynthesis of bile acids. Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids.

1984 • 127 citations

Testosterone metabolism by cytochrome P-450 isozymes RLM3 and RLM5 and by microsomes. Metabolite identification.

1983 • 126 citations

Mechanism of N-demethylation of aminopyrine by hydrogen peroxide catalyzed by horseradish peroxidase, metmyoglobin, and protohemin

1978 • 126 citations

Evidence for a homolytic mechanism of peroxide oxygen–oxygen bond cleavage during substrate hydroxylation by cytochrome P-450.

1980 • 124 citations

Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450

1976 • 124 citations

Amino acid sequence of an analogous peptide from two forms of cytochrome P-450.

1981 • 123 citations

Reconversion of detergent- and sulfhydryl reagent-produced P-420 to P-450 by polyols and glutathione

1967 • 123 citations

Multiple Forms of Cytochrome P-450 Purified from Liver Microsomes of Phenobarbital- and 3-Methylcholanthrene-Pretreated Rabbits

1980 • 123 citations

Heme ligand replacement reactions of cytochrome P-450. Characterization of the bonding atom of the axial ligand trans to thiolate as oxygen.

1982 • 114 citations

Identification of the major cytochrome P-450 form transplacentally induced in neonatal rabbits by 3,3,7,8-tetrachlorodibenzo-p-dioxin.

1978 • 113 citations

Role of a hydrophobic polypeptide in the N-terminal region of NADPH-cytochrome P-450 reductase in complex formation with P-450lm

1979 • 113 citations

Role of Cytochrome b5 in Hydroxylation by a Reconstituted Cytochrome P-450-containing System

1974 • 112 citations

Identification and localization of amino acid substitutions between two phenobarbital-inducible rat hepatic microsomal cytochromes P-450 by micro sequence analyses.

1983 • 112 citations

Amino-terminal sequence of phenobarbital-inducible cytochrome P-450 from rabbit liver microsomes: Similarity to hydrophobic amino-terminal segments of preproteins

1977 • 104 citations

Chemical characterization of protein-protein interactions between cytochrome P-450 and cytochrome b5.

1985 • 104 citations

Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat.

1985 • 104 citations

A prostaglandin omega-hydroxylase cytochrome P-450 (P-450PG-omega) purified from lungs of pregnant rabbits.

1984 • 102 citations

On the mechanism of action of cytochrome P-450. Evaluation of homolytic and heterolytic mechanisms of oxygen-oxygen bond cleavage during substrate hydroxylation by peroxides.

1981 • 99 citations

Carbon monoxide-combining substances in rat adrenal

1964 • 98 citations

The complete amino acid sequence of rabbit phenobarbital-induced liver microsomal cytochrome P-450.

1983 • 98 citations

Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidation

1982 • 98 citations

Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form

1984 • 97 citations

Microsomes and Drug Oxidations

1986 • 95 citations

The roles of cytochrome b5 in a reconstituted N-demethylase system containing cytochrome P-450

1977 • 93 citations

Purification and some properties of cytochrome P-450 specific for steroid 17α-hydroxylation and C17C20 bond cleavage from guinea pig adrenal microsomes

1982 • 92 citations

Effects of cytochrome b5 on cytochrome P-450-catalyzed reactions. Studies with manganese-substituted cytochrome b5.

1984 • 91 citations

Regio- and stereoselectivity of various forms of purified cytochrome P -450 in the metabolism of benzo[ a ]pyrene and (-) trans -7,8-dihydroxy-7,8-dihydrobenzo[ a ]pyrene as shown by product formation and binding to DNA

1978 • 91 citations

NH2-terminal sequence analyses of four rat hepatic microsomal cytochromes P-4501

1984 • 88 citations

Adrenodoxin interaction with adrenodoxin reductase and cytochrome P-450scc. Cross-linking of protein complexes and effects of adrenodoxin modification by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.

1984 • 88 citations

Purification of human liver cytochrome P-450 and comparison to the enzyme isolated from rat liver

1980 • 86 citations

Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1.

1985 • 86 citations

Comparative Structures of P-450 Cytochromes

1986 • 86 citations

On the mechanism of action of cytochrome P-450. Oxidation and reduction of the ferrous dioxygen complex of liver microsomal cytochrome P-450 by cytochrome b5.

1984 • 86 citations

Chemical characterization of cytochrome P-450cam

1970 • 86 citations

Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5.

1982 • 86 citations

Purification and characterization of cytochrome P-450meg.

1979 • 85 citations

Interaction of purified microsomal cytochrome P-450 with cytochrome b5

1981 • 85 citations

Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species.

1983 • 85 citations

Distribution of enzymes involved in metabolism of polycyclic aromatic hydrocarbons among rat liver endomembranes and plasma membranes.

1980 • 84 citations

Cytochrome b5 as electron donor to rabbit liver cytochrome P-450LM2 in reconstituted phospholipid vesicles

1980 • 84 citations

Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450.

1985 • 79 citations

Amino acid sequence of the Pseudomonas putida cytochrome P-450. II. Cyanogen bromide peptides, acid cleavage peptides, and the complete sequence.

1982 • 78 citations

The complete amino acid sequence of a constitutive form of liver microsomal cytochrome P-450.

1985 • 78 citations

Purification of cytochrome P-450 from bovine adrenocortical mitochondria by an “Aniline-sepharose” and the properties

1975 • 78 citations

Multiple forms of cytochrome P-450 in liver microsomes from beta-naphthoflavone-pretreated rats. Separation, purification, and characterization of five forms.

1982 • 77 citations

On the mechanism of action of cytochrome P-450. Spectral intermediates in the reaction of P-450LM2 with peroxy compounds.

1980 • 77 citations

Purification and properties of 17α-hydroxylase from microsomes of pig adrenal: A scond C21side-chain cleavage system

1983 • 76 citations

Purification and characterization of adrenal cortex mitochondrial cytochrome P-450 specific for cholesterol side chain cleavage activity.

1976 • 75 citations

NADH- and NADPH-Dependent Reconstituted p-Nitroanisole O-Demethylation System Containing Cytochrome P-450 with High Affinity for Cytochrome b51

1980 • 73 citations

Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase

1982 • 73 citations

The history, properties, and function of NADPH-cytochrome P-450 reductase

1980 • 72 citations

Mouse liver testosterone 15 alpha-hydroxylase (cytochrome P-450(15) alpha). Purification, regioselectivity, stereospecificity, and sex-dependent expression.

1984 • 71 citations

An infrared spectroscopic study of carbon monoxide bonding to ferrous cytochrome P-450

1978 • 70 citations

Isolation and characterization of a constitutive form of rabbit liver microsomal cytochrome P-450.

1980 • 70 citations

Interaction of liver microsomal cytochrome P-450 and NADPH-cytochrome P-450 reductase in the presence and absence of lipid.

1984 • 70 citations

Effects of conditions for reconstitution with cytochrome b5 on the formation of products in cytochrome P-450-catalyzed reactions.

1986 • 70 citations

Iodosylbenzene derivatives as oxygen donors in cytochrome P-450 catalyzed steroid hydroxylations

1979 • 68 citations

The Roles of Cytochrome b5 in Reconstituted Monooxygenase Systems Containing Various Forms of Hepatic Microsomal Cytochrome P-4501

1981 • 67 citations

Oxygen Reduction by the P450 Monoxygenase Systems

1979 • 66 citations

Amino-terminal and carboxy-terminal sequence of hepatic microsomal cytochrome P-450d, a unique hemoprotein from rats treated with isosafrole

1982 • 66 citations

Modification of cytochrome P-450 with fluorescein isothiocyanate

1983 • 66 citations

The many roles of cytochrome 5 in hepatic microsomes

1976 • 65 citations

Purification of liver microsomal cytochrome P-450 isozymes 3a and 6 from imidazole-treated rabbits. Evidence for the identity of isozyme 3a with the form obtained by ethanol treatment.

1984 • 65 citations

The covalent structure of rabbit phenobarbital-induced cytochrome P-450. Partial amino acid sequence and order of cyanogen bromide peptides.

1982 • 63 citations

[15] Purification of bacterial cytochrome P-450

1978 • 63 citations

Radical mechanism of aminopyrine oxidation by cumene hydroperoxide catalyzed by purified liver microsomal cytochrome P-450

1980 • 61 citations

Chemical structure of rat liver cytochrome b5 Isolation of peptides by high-pressure liquid chromatography

1982 • 60 citations

The primary structure of the monoxygenase cytochrome P450CAM

1982 • 60 citations

Mouse cytochrome P₃-450: complete cDNA and amino acid sequence

1984 • 60 citations

Gene structure and nucleotide sequence for rat cytochrome P-450c

1985 • 60 citations

Steroid 21-hydroxylase (cytochrome P-450) from porcine adrenocortical microsomes: microsequence analysis of cysteine-containing peptides

1983 • 59 citations

Demethylation of N,N-dimethylaniline and p-cyano-N,N-dimethylaniline and their N-oxides by cytochromes P450LM2 and P450CAM

1984 • 57 citations

Isolation of the membrane-binding peptide of NADPH-cytochrome P-450 reductase. Characterization of the peptide and its role in the interaction of reductase with cytochrome P-450.

1981 • 56 citations

Properties of the oxygenated form of liver microsomal cytochrome P-450.

1983 • 56 citations

Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450.

1976 • 56 citations

Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6.

1985 • 55 citations

Effect of a zwitterionic detergent on the state of aggregation and catalytic activity of cytochrome P-450LM2 and NADPH-cytochrome P-450 reductase.

1984 • 55 citations

Purification and reconstitution of the steroid 21-hydroxylase system (cytochrome P-450-linked mixed function oxidase system) of bovine adrenocortical microsomes.

1981 • 54 citations

Different requirement for cytochrome b5 in NADPH-supported O-deethylation of p-nitrophenetole catalyzed by two types of microsomal cytochrome P-450

1980 • 53 citations

[16] Purification of Rhizobium cytochrome P-450

1978 • 53 citations

P-450cam hydroxylase: substrate-effector and electron-transport reactions

1971 • 51 citations

Endogenous cysteine ligation in ferric and ferrous cytochrome P-450. Direct evidence from x-ray absorption spectroscopy.

1982 • 49 citations

The identification of the heat-stable microsomal protein required for methoxyflurane metabolism as cytochrome b5.

1984 • 49 citations

Genetic variability in responses to chemical exposure

1985 • 47 citations

The rabbit pulmonary monooxygenase system. partial structural characterization of the cytochrome P-450 components and comparison to the hepatic cytochrome P-450.

1981 • 46 citations

Evidence for the involvement of cytochrome P-450 in reduction of benzo(a)pyrene 4,5-oxide by rat liver microsomes

1976 • 45 citations

Purification and reconstitution of the steroid 21-hydroxylase system (cytochrome P-450-linked mixed function oxidase system) of bovine adrenocortical microsomes

1981 • 45 citations

Lipid-protein interactions as determinants of activation or inhibition by cytochrome b5 of cytochrome P-450-mediated oxidations.

1982 • 45 citations

Multiple mechanisms of cytochrome P450-catalyzed substrate hydroxylations

1981 • 44 citations

Aliphatic hydroxylation by cytochrome P-450. Evidence for rapid hydrolysis of an intermediate iron-nitrene complex

1984 • 42 citations

Chiral orientation of prosthetic heme in the cytochrome P-450 active site.

1983 • 41 citations

Multiple forms of noninduced rat liver cytochrome P-450. Metabolism of 1-(4'-ethylphenoxy)-3,7-dimethyl-6,7-epoxy-trans-2-octene by reconstituted preparations.

1979 • 40 citations

Purification and Characterization of Four Forms of Cytochrome P-450 from Liver Microsomes of Phenobarbital-Treated and 3-Methylcholanthrene-Treated Rats1

1984 • 40 citations

Bovine adrenocortical microsomal hemeproteins P-45017 alpha and P-450C-21. Isolation, partial characterization, and comparison to P-450SCC.

1982 • 38 citations

Cytochrome P-450-dependent oxidation of progesterone, testosterone, and ecdysone in the spiny lobster, Panulirus argus

1984 • 38 citations

Isosafrole-induced cytochrome P2-450 in DBA/2N mouse liver. Characterization and genetic control of induction.

1984 • 38 citations

Cytochrome P-450 from lodderomyces elongisporus: Its purification and some properties of the highly purified protein

1981 • 38 citations

Purification and characterization of mitochondrial cytochrome P-450 associated with cholesterol side chain cleavage from bovine corpus luteum.

1980 • 38 citations

Magnetic circular dichroism of purified forms of rabbit liver cytochromes P-450 and P-420

1978 • 38 citations

Hydroxylations in biosynthesis of bile acids. Isolation of subfractions with different substrate specificity from cytochrome P-450LM4.

1982 • 37 citations

The cytochrome P-450 monooxygenase system of rabbit bladder mucosa: enzyme components and isozyme 5-dependent metabolism of 2-aminofluorene.

1985 • 37 citations

On the amino acid sequence of cytochrome P-450 isozyme 4 from rabbit liver microsomes.

1984 • 36 citations

Structural features of isozyme 2 of liver microsomal cytochrome P-450. Identification of a highly conserved cysteine-containing peptide.

1982 • 35 citations

Oxygenated cytochrome P‐450_cam: Evidence against axial histidine ligation of iron

1978 • 33 citations

Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microhetero-geneous cytochrome P-450 variant: regulation of its messenger level by xenobiotics

1983 • 33 citations

Purification and characterization of a microsomal cytochrome P-450 with high activity of coumarin 7-hydroxylase from mouse lives

1984 • 32 citations

Complete stoichiometry of free NADPH oxidation in liver microsomes

1982 • 32 citations

Preparation and properties of side-chain cleavage cytochrome P-450 from bovine adrenal cortex by affinity chromatography with pregnenolone as ligand

1977 • 31 citations

Purification and Characterization of Cytochrome P-450 Specific for Prostaglandin and Fatty Acid Hydroxylase Activities from the Microsomes of Rabbit Small Intestinal Mucosa

1984 • 30 citations

Purification and characterization of pentobarbital-induced cytochrome P-450BM-1 from Bacillus megaterium ATCC 14581

1985 • 30 citations

Catalase, Glutathione Peroxidase, Superoxide Dismutase, and Cytochrome P-450

1983 • 29 citations

Isolation of immunochemically distinct form of cytochrome P-450 from microsomes of tulip bulbs

1983 • 28 citations

[12] Purification of adrenal cytochrome P-450 (cholesterol desmolase and steroid 11β- and 18-hydroxylase)

1978 • 28 citations

A Reevaluation of the Role of Cytochrome P-4S0 as the Terminal Oxidase in Hepatic Microsomal Mixed Function Oxidase Catalyzed Reactions

1979 • 28 citations

Amino-terminal sequence analysis of six cytochrome P-450 isozymes purified by monoclonal antibody directed immunopurification

1984 • 27 citations

Cytochrome P-450 isozyme LM3b from rabbit liver microsomes. Induction by triacetyloleandomycin purification and characterization.

1983 • 25 citations

Prostacyclin Synthase, a Cytochrome P450 Enzyme

1983 • 25 citations

The role of the sugar regions of components of the cytochrome p-450-linked mixed-function oxidase (monooxygenase) system of bovine adrenocortical mitochondria

1982 • 24 citations

Hydroxylation of Prostaglandin A1 by the Microsomes of Rabbit Intestinal Mucosa1

1984 • 24 citations

Cytochrome P-450

1984 • 24 citations

Amino acid sequence of the Pseudomonas putida cytochrome P-450. I. Sequences of tryptic and clostripain peptides.

1982 • 23 citations

Purification of cytochrome P-450 catalyzing 25-hydroxylation of vitamin D3 from rat liver microsomes

1984 • 22 citations

Studies on the identity of the heme-binding cysteinyl residue in rabbit liver microsomal cytochrome P-450 isozyme 2

1985 • 22 citations

Multiple Forms of Cytochrome P-450 in kidney Cortex Microsomes of Rabbits Treated with 3-Methylcholanthrene1

1982 • 21 citations

Involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes.

1981 • 20 citations

The Use of Animal Subcellular Fractions to Study Type I Metabolism of Xenobiotics

1979 • 20 citations

Rate-limiting steps in cytochrome P-450-catalysed reactions: Studies on isotope effects in theO-de-ethylation of 7-ethoxycoumarin

1984 • 19 citations

Fluorescent energy transfer measurements on fluorescein isothiocyanate modified cytochrome P-450 LM2

1983 • 18 citations

Identification of the ligand trans to thiolate in cytochrome P‐450 LM2 by chemical modification

1983 • 17 citations

Purification and Characterization of Cytochrome P-450 with High Affinity for 7-Alkoxycoumarins1

1984 • 14 citations

Structures of cysteine-containing peptides in isosafrole-inducible rat hepatic microsomal cytochrome P-450d: sequence homology with 3-methylcholanthrene-induced cytochrome P-450c.

1984 • 12 citations

Structural analysis of the cysteine-containing peptides from the major 3-methylcholanthrene-induced isozyme of cytochrome P-450 (P-450c) in rat liver microsomes

1984 • 12 citations

Isolation and characterization of a novel cytochrome P-450-like pseudogene

1986 • 12 citations

Peptide alignment of the porcine 21-hydroxylase cytochrome P-450 using a cDNA sequence of the corresponding bovine enzyme

1984 • 10 citations

Bioregulation of Binding and Dynamics: The Cytochrome P-450CAM Model

1985 • 9 citations

Purification and properties of cytochrome P-450 from untreated monkey liver microsomes

1984 • 7 citations

The Chemical Basis of Mixed Function Oxidation

1982 • 6 citations

Current Status of the Sequence Studies of the Pseudomonas Putida Camphor Hydroxylase System

1976 • 5 citations