Isolation and purification of cytochrome P-450, and the existence of multiple forms

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels

1976 • 1,060 citations

The O-Dealkylation of 7-Ethoxycoumarin by Liver Microsomes. A Direct Fluorometric Test

1972 • 634 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

1974 • 518 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems

1965 • 503 citations

Microsomes and Drug Oxidations

1970 • 463 citations

Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms.

1975 • 456 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

1956 • 393 citations

Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.

1977 • 367 citations

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

1966 • 357 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

A gel-electrophoretically homogeneous preparation of cytochrome P-450 from liver microsomes of phenobarbital-pretreated rabbits

1974 • 304 citations

[7] Purification and properties of NADPH-Cytochrome P-450 reductase

1978 • 303 citations

Fundamentals of Drug Metabolism and Drug Disposition

1973 • 270 citations

Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448.

1976 • 262 citations

Microsomes and Drug Oxidations

1978 • 256 citations

Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats

1978 • 255 citations

The Structural Basis of Membrane Function

1976 • 253 citations

Genetic Regulation of Aryl Hydrocarbon Hydroxylase Induction

1972 • 247 citations

Ligand interactions with cytochrome P-450. I. Binding of primary amines

1969 • 227 citations

The resolution and reconstitution of the liver microsomal hydroxylation system

1974 • 223 citations

Existence and Separation of Three Forms of Cytochrome P-450 from Rat Liver Microsomes

1973 • 221 citations

Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.

1969 • 218 citations

THE METABOLISM OF METHYLATED AMINOAZO DYES

1954 • 214 citations

Reconstituted Liver Microsomal Enzyme System That Hydroxylates Drugs, Other Foreign Compounds, and Endogenous Substrates

1973 • 208 citations

Multiplicity of cytochrome P450 hemoproteins in rat liver microsomes

1974 • 200 citations

Highly purified cytochrome P-448 and P-450 from rat liver microsomes

1975 • 189 citations

The Ah Locus and the Metabolism of Chemical Carcinogens and Other Foreign Compounds

1977 • 188 citations

Pregnenolone-16α-carbonitrile: A new type of inducer of drug-metabolizing enzymes

1972 • 188 citations

Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes

1979 • 180 citations

On the protective action of certain polycyclic aromatic hydrocarbons against carcinogenesis by aminoazo dyes and 2-acetylaminofluorene.

1958 • 180 citations

Carcinogens, Enzyme Induction, and Gene Action

1967 • 172 citations

Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems.

1977 • 164 citations

Cytochrome P-450 purified to apparent homogeneity from phenobarbital-induced rabbit liver microsomes: Catalytic activity and other properties

1974 • 164 citations

A simple and rapid procedure for the purification of phenobarbitalinducible cytochrome P-450 from rat liver microsomes

1979 • 163 citations

Separation, purification, and properties of multiple forms of cytochrome P-450 from the liver microsomes of phenobarbital-treated mice.

1976 • 159 citations

Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: Lipid requirement for drug demethylation

1969 • 152 citations

[10] Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450lm4 (rabbit liver)

1978 • 151 citations

Multiple forms of cytochrome P-450 in phenobarbital- and 3-methylcholanthrene-treated rats. Separation and spectral properties.

1975 • 150 citations

Preparation of Partially Purified, Lipid-depleted Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome c Reductase from Rat Liver Microsomes

1974 • 146 citations

Ligand interactions with hemoprotein P-450. II. Influence of phenobarbital and methylcholanthrene induction processes on P-450 spectra

1969 • 141 citations

Gel electrophoresis of partially purified cytochromes P450 from liver microsomes of variously-treated rats

1973 • 136 citations

Evidence for two forms of P-450 hemoprotein in microsomal membranes

1966 • 136 citations

Immunological comparison of hepatic and extrahepatic cytochromes P-450.

1979 • 135 citations

Purification of a substrate complex of cytochrome P-450 from liver microsomes of 3-methylcholanthrene-treated rabbits

1976 • 134 citations

Assembly of the Mitochondrial Membrane System

1973 • 127 citations

Liver tumor inhibition and adrenal histologic responses in rats to which 3'-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered.

1952 • 126 citations

Reconversion of detergent- and sulfhydryl reagent-produced P-420 to P-450 by polyols and glutathione

1967 • 123 citations

Sex differences in drug metabolism by rat liver microsomes.

1967 • 122 citations

Tetrahydrofurane - an inhibitor for ethanol-induced liver microsomal cytochrome P450

1975 • 121 citations

Aminopyrine demethylase kinetic evidence for multiple microsomal activities

1970 • 119 citations

An Affinity Column Method for Partial Purification of Cytochrome P-450 from Phenobarbital-induced Rabbit Liver Microsomes

1974 • 118 citations

Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes.

1978 • 117 citations

Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.

1969 • 111 citations

Drug Metabolism Concepts

1977 • 111 citations

Nuclear aryl hydrocarbon hydroxylase and interaction of polycyclic hydrocarbons with nuclear components

1977 • 106 citations

Amino-terminal sequence of phenobarbital-inducible cytochrome P-450 from rabbit liver microsomes: Similarity to hydrophobic amino-terminal segments of preproteins

1977 • 104 citations

Heterogeneity of liver microsomal cytochrome P-450: The spectral characterization of reactants with reduced cytochrome P-450

1975 • 103 citations

Microsomes and drug oxidation

1985 • 101 citations

The Use of 8-Aminooctyl Sepharose for the Separation of Some Components of the Hepatic Microsomal Electron Transfer System

1976 • 96 citations

Preparation and properties of highly purified cytochrome p-450 and NADPH-cytochrome P-450 reductase from pulmonary microsomes of untreated rabbits.

1977 • 93 citations

Evidence in Rat and Mouse Liver for Temporal Control of Two Forms of Cytochrome P-450 Inducible by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1978 • 91 citations

Regio- and stereoselectivity of various forms of purified cytochrome P -450 in the metabolism of benzo[ a ]pyrene and (-) trans -7,8-dihydroxy-7,8-dihydrobenzo[ a ]pyrene as shown by product formation and binding to DNA

1978 • 91 citations

Immunochemical studies on two electrophoretically homogeneous forms of rabbit liver microsomal cytochrome P-450: P-450LM2 and P-450LM4.

1977 • 90 citations

Characteristics of benzo(a)pyrene metabolism and cytochrome P-450 heterogeneity in rat liver nuclear envelope and comparison to microsomal membrane.

1978 • 87 citations

Properties of purified liver microsomal cytochrome P450 from rats treated with the polychlorinated biphenyl mixture Aroclor 1254.

1977 • 85 citations

Purification of liver microsomal cytochrome P-448 from 3-methylcholanthrene-treated rabbits.

1975 • 83 citations

Multiplicity of cytochrome P-450 hemoproteins in rat liver microsomes. Preparation and specificity of an antibody to the hemoprotein induced by phenobarbital.

1975 • 81 citations

Purification and properties of cytochrome P-450 obtained from liver microsomes of untreated rats by lauric acid affinity chromatography.

1978 • 81 citations

Studies of the metabolism of diethyl p-nitrophenyl phosphorothionate (parathion) and benzphetamine using an apparently homogeneous preparation of rat liver cytochrome P-450: effect of a cytochrome P-450 antibody preparation.

1976 • 79 citations

Resolution of two forms of cytochrome P-450 from liver microsomes of rabbit treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1977 • 78 citations

Regioselective and stereoselective hydroxylation of R and S warfarin by different forms of purified cytochrome P-450 from rabbit liver

1978 • 76 citations

Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.

1977 • 75 citations

Studies of the metabolism of parathion with an apparently homogeneous preparation of rabbit liver cytochrome P-450.

1976 • 73 citations

Multiple forms of cytochrome P450

1977 • 71 citations

The rabbit pulmonary monooxygenase system: Characteristics and activities of two forms of pulmonary cytochrome P-450

1978 • 69 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Induction

1973 • 69 citations

Position-specific oxygenation of benzo(a)pyrene by different forms of purified cytochrome P-450 from rabbit liver.

1975 • 69 citations

Liver microsomal drug-metabolizing enzyme system: functional components and their properties.

1976 • 68 citations

Hepatic mitochondrial cytochrome P -450: Isolation and functional characterization

1977 • 66 citations

Activation of monooxygenases in human liver by 7,8‐benzoflavone

1977 • 66 citations

Separation and purification of two forms of hepatic cytochrome P-450 from untreated rabbits.

1976 • 66 citations

[11] Purification of cytochrome P-450 and P-448 from rat liver microsomes

1978 • 63 citations

Reconstituted mammalian mixed-function oxidases: Requirements, specificities and other properties

1978 • 63 citations

Ethanol-induced cytochrome P-450: Catalytic activity after partial purification

1976 • 62 citations

Variations in extent of aryl hydrocarbon hydroxylase induction in cultured human lymphocytes.

1973 • 61 citations

Cytochromes P‐450 and bs in human liver microsomes

1969 • 60 citations

A novel haemoprotein induced by isosafrole pretreatment in the rat

1978 • 58 citations

Studies on the purification of rat liver uridine diphosphate glucuronyltransferase

1977 • 51 citations

Oxidative drug metabolism in human liver microsomes.

1971 • 51 citations

Multiple forms of cytochrome P-450: Resolution and purification of rabbit liver aryl hydrocarbon hydroxylase

1977 • 50 citations

Further Studies on Genetically Mediated Differences in Monooxygenase Activities and Spin State of Cytochrome P450 Iron from Rabbit, Rat, and Mouse Liver

1973 • 47 citations

Cytochrome P-450cam

1974 • 46 citations

Comparison of highly-purified microsomal cytochromes P-450 and NADPH-cytochrome P-450 reductases by peptide mapping

1978 • 42 citations

Purification of the major cytochrome P-450 of liver microsomes from rabbits treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1977 • 40 citations

Multiple Forms of Cytochrome P‐450 in Rat‐Liver Microsomes

1976 • 39 citations

Magnetic circular dichroism of purified forms of rabbit liver cytochromes P-450 and P-420

1978 • 38 citations

Biochemical Studies on Drug Metabolism: Isolation of Multiple Forms of Liver Microsomal Cytochrome P-450

1977 • 37 citations

SPECIFICITY IN THE REGULATION OF THE 6β-, 7α AND 16α-HYDROXYLATION OF TESTOSTERONE BY RAT LIVER MICROSOMES

1969 • 36 citations

Rat hepatic microsomal cytochrome(s) P-450 induced by polybrominated biphenyls.

1978 • 35 citations

Human liver microsomal drug metabolism

1970 • 35 citations

Characterization of Electron Transport Enzymes in the Envelope of Rat Liver Nuclei

1978 • 32 citations

Drug and fatty acid hydroxylation by solubilized human liver microsomal cytochrome P-450—Phospholipid requirement

1975 • 30 citations

The role of microsomes and nuclear envelope in the metabolic activation of benzo(a)pyrene leading to binding with nuclear macromolecules.

1977 • 27 citations

[19] Purification and assay of liver microsomal epoxide hydrase

1978 • 25 citations

A novel electrophoretic pattern of induction of rat liver microsomal membrane polypeptides by 2-acetylaminofluorene, nitrosamine and azo dye administration

1976 • 23 citations

LIVER MICROSOMAL MEMBRANES: RECONSTITUTION OF THE HYDROXYLATION SYSTEM CONTAINING CYTOCHROME P-450*

1976 • 21 citations

Relationship between induction of aryl hydrocarbon hydroxylase and de novo synthesis of cytochrome P-448 (P1-450) in mice

1976 • 17 citations

Drug metabolism in liver tumors. Resolution of components and reconstitution of activity.

1976 • 14 citations

PURIFICATION OF LIVER MICROSOMAL CYTOCHROME P-450: HOPES AND PROMISES

1977 • 12 citations

AMINIMIDE POLYMERS AS SUPPORTS FOR AFFINITY CHROMATOGRAPHY, UNDER LOW AND HIGH PRESSURE, OF MICROSOMAL ENZYMES

1977 • 2 citations