The cytochrome P-450 active site. Regiospecificity of prosthetic heme alkylation by olefins and acetylenes.

Microsomes, drug oxidations, and drug toxicity

1982 • 187 citations

Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates.

1980 • 178 citations

N-Phenylprotoporphyrin IX formation in the hemoglobin-phenylhydrazine reaction. Evidence for a protein-stabilized iron-phenyl intermediate.

1982 • 153 citations

Destruction of cytochrome P-450 by ethylene. Structure of the resulting prosthetic heme adduct.

1981 • 102 citations

Destruction of cytochrome P-450 by ethylene and other olefins.

1980 • 102 citations

Dynamic protein structures: infrared evidence for four discrete rapidly interconverting conformers at the carbon monoxide binding site of bovine heart myoglobin.

1981 • 101 citations

Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidation

1982 • 98 citations

Selective inactivation of cytochrome P-450 isozymes by suicide substrates

1981 • 89 citations

Stereochemistry of cytochrome P-450-catalyzed epoxidation and prosthetic heme alkylation.

1983 • 79 citations

N-Methylprotoporphyrin IX: chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine treatment.

1981 • 74 citations

Formation of N-phenylheme in the hemolytic reaction of phenylhydrazine with hemoglobin

1981 • 65 citations

Cytochrome P-450 inactivation: structure of the prosthetic heme adduct with propyne

1981 • 57 citations

Absolute configuration of the trans-9,10-dihydrodiol metabolite of the carcinogen benzo[a]pyrene

1982 • 34 citations

N-Methylprotoporphyrin IX. Identification by NMR of the nitrogen alkylated in each of the four isomers

1981 • 32 citations

Alkylation of the prosthetic heme in cytochrome P-450 during oxidative metabolism of the sedative-hypnotic ethchlorvynol

1982 • 23 citations

Bioactivation of Foreign Compounds

1987 • 14 citations

Interaction of Polycyclic Hydrocarbons with Cytochrome P-450. III. Effects of Hydrocarbon Binding on the Interaction of Some Ligands with P-4481 Heme1

1982 • 14 citations