Rate-limiting steps in cytochrome P-450-catalysed reactions: Studies on isotope effects in theO-de-ethylation of 7-ethoxycoumarin

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

The O-Dealkylation of 7-Ethoxycoumarin by Liver Microsomes. A Direct Fluorometric Test

1972 • 634 citations

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

1978 • 531 citations

Concepts in drug metabolism

1980 • 237 citations

Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monooxygenase system

1982 • 189 citations

Use of Isotope Effects to Elucidate Enzyme Mechanism

1982 • 167 citations

What limits the rate of an enzyme-catalyzed reaction

1975 • 148 citations

Mechanistic deductions from isotope effects in multireactant enzyme mechanisms

1981 • 142 citations

Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450

1977 • 126 citations

Kinetic isotope effects in cytochrome P-450-catalyzed oxidation reactions. Intermolecular and intramolecular deuterium isotope effects during the N-demethylation of N,N-dimethylphentermine.

1980 • 83 citations

Uncatalyzed rates of enolization of dihydroxyacetone phosphate and of glyceraldehyde 3-phosphate in neutral aqueous solution. Quantitative assessment of the effectiveness of an enzyme catalyst

1975 • 73 citations

Isotope effects in O- and N-demethylations mediated by rat liver microsomes: An application of direct insertion electron impact mass spectrometry

1974 • 73 citations

Minimal kinetic mechanism and general equation for deuterium isotope effects on enzymic reactions: uncertainty of detecting a rate-limiting step

1981 • 67 citations

Cytochrome b₅ as Electron Donor for Oxy‐cytochrome P‐450

1981 • 62 citations

Studies on the stimulation of cytochrome P-450-dependent monooxygenase activity by dilauroylphosphatidylcholine

1981 • 48 citations

Chapter 32. The Use of Stable Isotopes in Medicinal Chemistry

1977 • 8 citations

The synthesis of ¹⁴C, ³H and ²H labeled 7‐ethoxycoumarins

1983 • 7 citations

Kinetic Isotope Effects in Cytochrome P-450-Catalyzed Oxidation Reactions. II. Interactions of Cytochrome P-450 with Substrates and Nadph-Cytochrome % MathType!MTEF!2!1!+-% feaagCart1ev2aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGabm4yayaaDa% aaaa!3700! $$\underset{\raise0.3em\hbox{$\…

1980 • 1 citations