Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Biochemical Evolution

1977 • 1,283 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

A mew computer method for the storage and manipulation of DNA gel reading data

1980 • 679 citations

Multiplicity of mammalian microsomal cytochromes P-45.

1979 • 633 citations

Random subcloning of sonicated DNA: Application to shotgun DNA sequence analysis

1983 • 605 citations

Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation.

1979 • 401 citations

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

1956 • 393 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity

1974 • 326 citations

Genetic Mechanisms Controlling the Induction of Polysubstrate Monooxygenase (P-450) Activities

1981 • 296 citations

Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.

1980 • 256 citations

Concepts in drug metabolism

1980 • 237 citations

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

1984 • 208 citations

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

1984 • 199 citations

Pregnenolone-16α-carbonitrile: A new type of inducer of drug-metabolizing enzymes

1972 • 188 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism.

1984 • 182 citations

SEQ: a nucleotide sequence analysis and recombination system

1982 • 179 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo.

1984 • 175 citations

Molecular clock of silent substitution: At least six-fold preponderance of silent changes in mitochondrial genes over those in nuclear genes

1982 • 154 citations

Stimulatory Effect of Foreign Compounds on Ascorbic Acid Biosynthesis and on Drug-Metabolizing Enzymes

1959 • 153 citations

Structural Characteristics of Cytochrome P-450. Possible Location of the Heme-Binding Cysteine in Determined Amino-Acid Sequences

1983 • 146 citations

Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes.

1983 • 146 citations

Two steroid 21-hydroxylase genes are located in the murine S region

1984 • 135 citations

Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.

1983 • 133 citations

Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC

1984 • 129 citations

Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver.

1984 • 129 citations

Amino acid sequence of an analogous peptide from two forms of cytochrome P-450.

1981 • 123 citations

Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.

1985 • 123 citations

Tissue distribution of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.

1979 • 122 citations

The complete amino acid sequence of rabbit phenobarbital-induced liver microsomal cytochrome P-450.

1983 • 98 citations

Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form

1984 • 97 citations

Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species.

1983 • 85 citations

Amino acid sequence of the Pseudomonas putida cytochrome P-450. II. Cyanogen bromide peptides, acid cleavage peptides, and the complete sequence.

1982 • 78 citations

Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

1983 • 78 citations

Die Beschleunigung des Evipanabbaues unter der Wirkung von Barbituraten

1958 • 69 citations

Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16 alpha-carbonitrile. Characterization of its mRNA, gene, and induction response.

1983 • 66 citations

Mouse cytochrome P₃-450: complete cDNA and amino acid sequence

1984 • 60 citations

Nucleic acid squence database computer system

1982 • 40 citations

Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9.

1984 • 39 citations

The induction of microsomal electron transport enzymes

1983 • 21 citations