Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

1962 • 1,431 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Porphyrins and Metalloporphyrins

1964 • 994 citations

An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1978 • 618 citations

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 • 576 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 523 citations

Food flavourings and compounds of related structure. II. Subacute and chronic toxicity

1967 • 472 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

Partial purification of cytochromes P-450 and P-448 from rat liver microsomes

1972 • 270 citations

Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448.

1976 • 262 citations

Increased Activity of Androgen Hydroxylases in Liver Microsomes of Rats Pretreated with Phenobarbital and Other Drugs

1963 • 250 citations

Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat liver

1975 • 186 citations

Interaction of Methylenedioxyphenyl (1,3-Benzodioxole) Compounds with Enzymes and Their Effects on Mammals

1975 • 183 citations

Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes

1979 • 180 citations

Liver microsomal expoxide hydrase. Solubilization, purification, and characterization.

1975 • 170 citations

Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholanthrene.

1979 • 153 citations

Multiple forms of cytochrome P-450 in phenobarbital- and 3-methylcholanthrene-treated rats. Separation and spectral properties.

1975 • 150 citations

Hepatic microsomal epoxide hydrase: a sensitive radiometric assay for hydration of arene oxides of carcinogenic aromatic hydrocarbons.

1977 • 147 citations

Preparation of Partially Purified, Lipid-depleted Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome c Reductase from Rat Liver Microsomes

1974 • 146 citations

Evidence for two forms of P-450 hemoprotein in microsomal membranes

1966 • 136 citations

The Enzymic Formation of a Methylenedioxyphenyl Derivative Exhibiting an Isocyanide-like Spectrum with Reduced Cytochrome P-450 in Hepatic Microsomes

1971 • 134 citations

Protein fingerprinting by SDS-gel electrophoresis after partial fragmentation with CNBr

1979 • 133 citations

Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448.

1976 • 133 citations

Microsomes and Drug Oxidations

1977 • 131 citations

Toxicity and related physiological activity of phenolic substances of plant origin

1969 • 127 citations

Microsomal metabolism of parathion

1967 • 111 citations

The influence of some hepatic enzyme inducers and inhibitors on extrahepatic drug metabolism.

1973 • 109 citations

A cytochrome P-450-piperonyl butoxide spectrum similar to that produced by ethyl isocyanide

1971 • 108 citations

Inhibition of microsomal drug metabolism by methylenedioxybenzenes

1968 • 101 citations

Liver microsomal epoxide hydrase.

1977 • 99 citations

Liver tumours produced in rats by feeding safrole.

1963 • 92 citations

Metabolism of N:N-dialkyl carbamates and related compounds by rat liver

1961 • 88 citations

Chromatographic and electrophoretic heterogeneity of the cytochromes P-450 solubilized from untreated rat liver.

1978 • 88 citations

Preparation of a porphyrin-iron-carbene model for the cytochrome P 450 complexes obtained upon metabolic oxidation of the insecticide synergists of the 1,3-benzodioxole series

1979 • 85 citations

Properties of purified liver microsomal cytochrome P450 from rats treated with the polychlorinated biphenyl mixture Aroclor 1254.

1977 • 85 citations

Purification of liver microsomal cytochrome P-448 from 3-methylcholanthrene-treated rabbits.

1975 • 83 citations

Studies on the interaction of safrole with rat hepatic microsomes

1975 • 82 citations

Inhibition of hepatic oxidative xenobiotic metabolism by piperonyl butoxide

1972 • 78 citations

Further studies on the dissociation of the isosafrole metabolite-cytochrome p-450 complex

1979 • 62 citations

A novel haemoprotein induced by isosafrole pretreatment in the rat

1978 • 58 citations

Structure-activity relations for methylenedioxyphenyl and related compounds on hepatic microsomal enzyme function, as measured by prolongation of hexobarbital narcosis and zoxazolamine paralysis in mice

1970 • 50 citations

Insecticide synergist interactions with cytochrome P-450 in mouse liver microsomes

1970 • 48 citations

The induction of hepatic microsomal enzymes by safrole

1970 • 46 citations

The effect of piperonyl butoxide concentration on the formation of cytochrome P-450 difference spectra in hepatic microsomes from mice.

1972 • 45 citations

Induction of hepatic microsomal hydroxylating enzymes by technical piperonyl butoxide and some of its analogs

1971 • 42 citations

Comparison of highly-purified microsomal cytochromes P-450 and NADPH-cytochrome P-450 reductases by peptide mapping

1978 • 42 citations

Induction of a new hepatic microsomal haemoprotein by safrole and isosafrole

1971 • 42 citations

The electron spin resonance and absorption spectra of microsomal cytochrome P-450 and its isocyanide complexes

1968 • 40 citations

Characterization of three forms of rabbit microsomal cytochrome P-450 by peptide mapping utilizing limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis

1979 • 35 citations

Effects of safrole and isosafrole pretreatment on N- and ring-hydroxylation of 2-acetamidofluorene by the rat and hamster

1972 • 31 citations

Cumene Hydroperoxide-Mediated Formation of Inhibited Complexes of Methylenedioxyphenyl Compounds with Cytochrome P-450

1975 • 25 citations

Substrate-elicited dissociation of a complex of cytochrome P-450 with a methylenedioxyphenyl metabolite

1976 • 23 citations

Structure-Binding Relationships between Benzimidazoles and Cytochrome P-450

1975 • 14 citations

Thin-layer chromatography of rat bile and urine following intravenous administration of safrole, isosafrole, and dihydrosafrole

1967 • 10 citations

Abstracts of papers for the Eighth Annual Meeting of the Society of Toxicology, Williamsburg, Virginia March 10–12, 1969

1969 • 6 citations