Cadherins and catenins: role in signal transduction and tumor progression.

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1998 • 1,548 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

1996 • 1,156 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

1998 • 1,082 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

1994 • 969 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 • 908 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

1996 • 864 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers

1998 • 846 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

1995 • 803 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.

1995 • 763 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

1998 • 722 citations

Developmental Defects in Mouse Embryos Lacking N-Cadherin

1997 • 712 citations

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

1997 • 702 citations

Lack of β-catenin affects mouse development at gastrulation

1995 • 700 citations

Structural basis of calcium-induced E-cadherin rigidification and dimerization

1996 • 688 citations

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1998 • 679 citations

Three-Dimensional Structure of the Armadillo Repeat Region of β-Catenin

1997 • 678 citations

Expressed recombinant cadherins mediate cell sorting in model systems

1988 • 673 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Identification of the receptor component of the IκBα–ubiquitin ligase

1998 • 648 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.

1995 • 635 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

Mutations of the human E-cadherin (CDH1) gene

1998 • 598 citations

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

1998 • 566 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

1991 • 536 citations

A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus

1997 • 527 citations

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

1998 • 512 citations

Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion

1998 • 505 citations

The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression

1991 • 501 citations

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila

1997 • 494 citations

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

1997 • 493 citations

Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

1998 • 489 citations

Signal transduction by the Wnt family of ligands

1998 • 474 citations

Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.

1995 • 471 citations

E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1

1998 • 451 citations

LEF-1, a Nuclear Factor Coordinating Signaling Inputs from wingless and decapentaplegic

1997 • 450 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3.

1998 • 441 citations

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

1998 • 429 citations

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

1998 • 421 citations

In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death.

1995 • 416 citations

Transformation by Wnt family proteins correlates with regulation of beta-catenin.

1997 • 412 citations

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

1998 • 395 citations

Decreased Mutual Adhesiveness, a Property of Cells from Squamous Cell Carcinomas

1944 • 391 citations

Beta-catenin mutation in carcinoma of the uterine endometrium.

1998 • 370 citations

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

1998 • 369 citations

Beta-catenin mutations in human prostate cancer.

1998 • 368 citations

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.

1991 • 364 citations

Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas.

1998 • 350 citations

α-Catenin-Vinculin Interaction Functions to Organize the Apical Junctional Complex in Epithelial Cells

1998 • 338 citations

Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.

1996 • 335 citations

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

1998 • 329 citations

Embryonic Heart and Skin Defects in Mice Lacking Plakoglobin

1996 • 323 citations

Tyrosine phosphorylation and cadherin/catenin function

1997 • 318 citations

Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion

1997 • 306 citations

TCF/LEF factors earn their wings

1997 • 288 citations

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

1985 • 286 citations

Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations.

1998 • 276 citations

Differential Nuclear Translocation and Transactivation Potential of β-Catenin and Plakoglobin

1998 • 271 citations

p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo.

1992 • 266 citations

Vinculin Is Part of the Cadherin–Catenin Junctional Complex: Complex Formation between α-Catenin and Vinculin

1998 • 260 citations

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

1998 • 258 citations

Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell–Cell Adhesion

1998 • 254 citations

Precocious Mammary Gland Development in P-Cadherin–deficient Mice

1997 • 252 citations

LEF-1/TCF Proteins Mediate Wnt-Inducible Transcription from the Xenopus Nodal-Related 3 Promoter

1997 • 244 citations

Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.

1991 • 232 citations

The E-cadherin/Catenin Complex in Invasion and Metastasis

1996 • 227 citations

Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system.

1996 • 221 citations

Regulation of Armadillo by a Drosophila APC Inhibits Neuronal Apoptosis during Retinal Development

1998 • 220 citations

The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element.

1991 • 216 citations

An α- E-catenin gene trap mutation defines its function in preimplantation development

1997 • 214 citations

Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3β and β-Catenin and Inhibits Axis Formation ofXenopus Embryos

1998 • 205 citations

Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.

1998 • 204 citations

E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model.

1996 • 193 citations

Pontin52, an interaction partner of β-catenin, binds to the TATA box binding protein

1998 • 187 citations

Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein

1996 • 186 citations

Effects of Forced Expression of an NH2-terminal Truncated β-Catenin on Mouse Intestinal Epithelial Homeostasis

1998 • 183 citations

Expression Cloning of Oncogenes by Retroviral Transfer of cDNA Libraries

1995 • 178 citations

beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex.

1996 • 172 citations

The Nonreceptor Protein Tyrosine Phosphatase PTP1B Binds to the Cytoplasmic Domain of N-Cadherin and Regulates the Cadherin–Actin Linkage

1998 • 163 citations

Expression of E-cadherin-associated molecules (alpha-, beta-, and gamma-catenins and p120) in colorectal polyps.

1997 • 161 citations

RB and c-Myc Activate Expression of the E-Cadherin Gene in Epithelial Cells through Interaction with Transcription Factor AP-2

1998 • 161 citations

Direct association of presenilin‐1 with β‐catenin

1998 • 159 citations

Prognostic value of E-cadherin expression in 413 gastric carcinomas

1996 • 156 citations

Wnt5a cloning, expression, and up-regulation in human primary breast cancers.

1995 • 154 citations

β-TrCP is a negative regulator of the Wnt/β-catenin signaling pathway and dorsal axis formation in Xenopus embryos

1998 • 152 citations

Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo.

1995 • 147 citations

TCF: transcriptional activator or repressor?

1998 • 144 citations

Mechanisms Identified in the Transcriptional Control of Epithelial Gene Expression

1996 • 142 citations

Mutations in beta-catenin are uncommon in colorectal cancer occurring in occasional replication error-positive tumors.

1997 • 141 citations

Structural and functional diversity of cadherin superfamily: Are new members of cadherin superfamily involved in signal transduction pathway?

1996 • 139 citations

Expression of E‐cadherin (E‐CD) as related to other prognostic factors and survival in breast cancer

1994 • 132 citations

High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

1998 • 129 citations

Dynamics of β-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis

1997 • 127 citations

Role of morphogenetic factors in metastasis of mammary carcinoma cells

1998 • 122 citations

Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer cells.

1996 • 110 citations

No evidence for mutations in the alpha- and beta-catenin genes in human gastric and breast carcinomas.

1996 • 109 citations

Immunohistological analysis of E-cadherin, α-, β- and γ-catenin expression in colorectal cancer: implications for cell adhesion and signaling

1999 • 102 citations

Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.

1998 • 94 citations

Expression of E-cadherin and catenins in invasive mammary carcinomas.

1997 • 93 citations

Wingless signaling: The inconvenient complexities of life

1998 • 78 citations

Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts

1998 • 78 citations

Identification and Chromosomal Localization of CTNNAL1, a Novel Protein Homologous to α-Catenin

1998 • 31 citations

EXPRESSION OF E-CADHERIN AND ALPHA-CATENIN MOLECULES IN HUMAN BREAST-CANCER TISSUES AND ASSOCIATION WITH CLINICOPATHOLOGICAL FEATURES

1994 • 30 citations

A beta-catenin mutation in a sporadic colorectal tumor of the RER phenotype and absence of beta-catenin germline mutations in FAP patients.

1998 • 28 citations

Deleted Work

1955 • 0 citations