The E-cadherin/Catenin Complex in Invasion and Metastasis

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

1973 • 2,431 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

1986 • 1,408 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

1994 • 1,131 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Biological Diversity in Metastatic Neoplasms: Origins and Implications

1982 • 937 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells

1994 • 913 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

1988 • 810 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Control of Cell Behavior During Vertebrate Development by Slug , a Zinc Finger Gene

1994 • 744 citations

A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16

1985 • 715 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

CELL ADHESION MOLECULES: Implications for a Molecular Histology

1991 • 707 citations

Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.

1990 • 697 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Expressed recombinant cadherins mediate cell sorting in model systems

1988 • 673 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development

1986 • 653 citations

The Insulin-Like Growth Factors

1993 • 647 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer.

1992 • 612 citations

Functional correlation between cell adhesive properties and some cell surface proteins.

1977 • 606 citations

Phytoestrogen Interaction with Estrogen Receptors in Human Breast Cancer Cells*

1978 • 605 citations

Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.

1989 • 598 citations

Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

1994 • 594 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

Plant Flavonoids in Biology and Medicine, Biochemical, Pharmacological and Structure-Activity Relationships

1986 • 562 citations

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

1994 • 557 citations

Structural basis of latency in plasminogen activator inhibitor-1

1992 • 552 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

1991 • 536 citations

Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer.

1994 • 534 citations

Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion

1991 • 532 citations

Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts.

1992 • 519 citations

A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.

1986 • 510 citations

A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.

1995 • 498 citations

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.

1994 • 490 citations

Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

1993 • 483 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas.

1993 • 457 citations

Cell and tissue interactions

1977 • 449 citations

Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity

1990 • 444 citations

Cadherins

1992 • 437 citations

Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin.

1989 • 436 citations

E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration.

1993 • 434 citations

A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos.

1986 • 424 citations

wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo

1994 • 423 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

Solution Structure of the Epithelial Cadherin Domain Responsible for Selective Cell Adhesion

1995 • 414 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.

1994 • 405 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.

1992 • 385 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Expression of immunoreactive E-cadherin adhesion molecules in human cancers.

1991 • 379 citations

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.

1991 • 366 citations

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.

1991 • 364 citations

Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.

1991 • 363 citations

Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors.

1993 • 362 citations

Expression of E- and P-cadherin in gastric carcinomas.

1991 • 345 citations

Cell-cell interactions in early embryogenesis: A molecular approach to the role of calcium

1981 • 338 citations

Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness.

1992 • 337 citations

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

1994 • 326 citations

The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions.

1990 • 305 citations

The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion.

1987 • 304 citations

Conformational changes of the recombinant extracellular domain of E‐cadherin upon calcium binding

1994 • 303 citations

Steps in the morphogenesis of a polarized epithelium : I. uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts

1990 • 302 citations

Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes

1993 • 298 citations

E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.

1993 • 297 citations

Identification of a membrane-cytoskeletal complex containing the cell adhesion molecule uvomorulin (E-cadherin), ankyrin, and fodrin in Madin-Darby canine kidney epithelial cells.

1990 • 294 citations

Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells.

1993 • 294 citations

E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro

1994 • 289 citations

E-cadherin gene mutations in human gastric carcinomacell lines.

1994 • 288 citations

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

1985 • 286 citations

Single amino acid substitutions in one Ca2+ binding site of uvomorulin abolish the adhesive function

1990 • 286 citations

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.

1994 • 284 citations

Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.

1992 • 280 citations

Mutations of the E–cadherin gene in human gynecologic cancers

1994 • 280 citations

Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.

1994 • 274 citations

Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin.

1981 • 271 citations

Insulin-like Growth Factor I Receptor β-Subunit Heterogeneity

1989 • 259 citations

Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome.

1994 • 257 citations

E-cadherin and alpha-catenin expression in human esophageal cancer.

1994 • 253 citations

Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.

1993 • 249 citations

Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer.

1993 • 248 citations

Identification of a putative cell adhesion domain of uvomorulin.

1985 • 246 citations

A Short Core Region of E-cadherin is Essential for Catenin Binding and is Highly Phosphorylated

1994 • 234 citations

Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.

1991 • 232 citations

E-cadherin expression during the differentiation of human trophoblasts

1991 • 227 citations

Cell sorting-out is modulated by both the specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surfaces.

1989 • 227 citations

Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells.

1991 • 226 citations

Loss of E-Cadherin-Dependent Cell-Cell Adhesion due to Mutation of the β-Catenin Gene in a Human Cancer Cell Line, HSC-39

1995 • 225 citations

Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1)

1995 • 225 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin.

1990 • 222 citations

The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element.

1991 • 216 citations

Methods of study of the invasion of malignant C3H-mouse fibroblasts into embryonic chick heart in vitro

1979 • 213 citations

Cysteine proteinases and metastasis

1984 • 211 citations

Ontogenetic expression of cell adhesion molecules: L-CAM is found in epithelia derived from the three primary germ layers

1984 • 211 citations

Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells.

1994 • 209 citations

Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin)

1991 • 208 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

Proteins associated with with cytoplasmic surface of adhesion molecules

1993 • 204 citations

Early epochal maps of two different cell adhesion molecules.

1983 • 204 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Epithelial (E‐) and placentae (P‐) cadherin cell adhesion molecule expression in breast carcinoma

1993 • 200 citations

Regulation of cell movement: the motogenic cytokines

1991 • 199 citations

Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen.

1994 • 198 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

Expression sequences of cell adhesion molecules.

1985 • 193 citations

Laminin increases the release of type IV collagenase from malignant cells.

1986 • 188 citations

Down‐regulation of E‐cadherin expression in madin darby canine kidney (MDCK) cells inside tumors of nude mice

1991 • 183 citations

Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities.

1991 • 182 citations

Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma

1991 • 180 citations

Soluble E-cadherin fragments increased in circulation of cancer patients

1994 • 178 citations

N-linked oligosaccharides are not involved in the function of a cell-cell binding glycoprotein E-cadherin.

1986 • 177 citations

E‐cadherin expression in head and neck squamous‐cell carcinoma is associated with clinical outcome

1993 • 176 citations

Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine.

1994 • 176 citations

Endocytosis of junctional cadherins in bovine kidney epithelial (MDBK) cells cultured in low Ca2+ ion medium.

1991 • 173 citations

Decreased expression of E-cadherin in the progression of rat prostatic cancer.

1992 • 173 citations

Cadherin Function Is Required for Human Keratinocytes to Assemble Desmosomes and Stratify in Response to Calcium

1994 • 172 citations

E-cadherin: a differentiation marker in thyroid malignancies.

1993 • 172 citations

Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.

1986 • 166 citations

Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck

1992 • 165 citations

Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells.

1994 • 165 citations

Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM.

1987 • 163 citations

c-erbB-2 Gene Product Associates with Catenins in Human Cancer Cells

1994 • 162 citations

Adhesion Molecules. I: Keratinocyte-Keratinocyte Interactions; Cadherins and Pemphigus

1995 • 158 citations

Unstable Expression of E‐Cadherin Adhesion Molecules in Metastatic Ovarian Tumor Cells

1989 • 157 citations

Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps.

1994 • 156 citations

Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease

1991 • 155 citations

Laminin receptors and laminin-binding proteins during tumor invasion and metastasis.

1993 • 154 citations

Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion.

1993 • 153 citations

cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells.

1990 • 147 citations

Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene.

1994 • 146 citations

Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells.

1990 • 144 citations

Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas.

1994 • 140 citations

Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line

1995 • 138 citations

Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer

1992 • 137 citations

Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer

1993 • 137 citations

Differential expression of the cell‐cell adhesion molecule E‐cadherin in ascites and solid human ovarian tumor cells

1994 • 135 citations

Expression of E‐cadherin (E‐CD) as related to other prognostic factors and survival in breast cancer

1994 • 132 citations

Effect of Wnt-1 and Related Proteins on Gap Junctional Communication in Xenopus Embryos

1991 • 129 citations

Point Mutation of the E–Cadherin Gene in Invasive Lobular Carcinoma of the Breast

1994 • 128 citations

Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line.

1993 • 126 citations

E-cadherin expression in renal cell cancer and its significance in metastasis and survival

1995 • 125 citations

Differential regulation of growth and invasiveness of MCF-7 breast cancer cells by antiestrogens.

1988 • 123 citations

Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells.

1994 • 122 citations

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-basedin vitro assays

1993 • 122 citations

Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumors.

1993 • 121 citations

Localization of the Human β-Catenin Gene (CTNNB1) to 3p21: A Region Implicated in Tumor Development

1994 • 121 citations

Distinct cadherin—catenin complexes in Ca²⁺ dependent cell—cell adhesion

1994 • 120 citations

Type 1 IGF receptor in human breast diseases

1992 • 120 citations

Expression of a novel cadherin (EP-cadherin) in unfertilized eggs and early Xenopus embryos

1991 • 120 citations

Formation of heterotypic adherens-type junctions between L-CAM-containing liver cells and A-CAM-containing lens cells

1987 • 119 citations

Expression of E-Cadherin in Normal, Benign, and Malignant Tissues of Female Genital Organs

1992 • 116 citations

Tamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype.

1994 • 115 citations

In vivo and in vitro invasiveness of a rat colon‐cancer cell line maintaining E‐cadherin expression: An enhancing role of tumor‐associated myofibroblasts

1994 • 115 citations

Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin

1988 • 113 citations

Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer

1994 • 112 citations

Demonstration of insulin-like growth factor (IGF-I and -II) receptors and binding protein in human breast cancer cell lines

1988 • 110 citations

Immunohistochemical detection of alpha-catenin expression in human cancers.

1994 • 110 citations

Topology of cell adhesion molecules.

1989 • 109 citations

Decreased E-Cadherin Expression in Endometrial Carcinoma Is Associated with Tumor Dedifferentiation and Deep Myometrial Invasion

1994 • 109 citations

The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis

1993 • 109 citations

Spheroid Culture in Cancer Research (1991)

2017 • 106 citations

Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells

1992 • 105 citations

Local and transient expression of E-cadherin involved in mouse embryonic brain morphogenesis

1992 • 102 citations

A possible new adhesive site in the cell-adhesion molecule uvomorulin

1990 • 102 citations

How and when do tumor cells metastasize?

1993 • 101 citations

Laminin Receptors

1991 • 101 citations

Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas

1993 • 101 citations

Defining E-cadherin-associated protein complexes in epithelial cells: plakoglobin β- and γ-catenin are distinct components

1993 • 100 citations

Differential effects of the cytoplasmic domains of cell adhesion molecules on cell aggregation and sorting-out.

1990 • 99 citations

Expression of IGF-I and IGF-II mRNA in breast tissue

1992 • 99 citations

Remodeling the cell surface distribution of membrane proteins during the development of epithelial cell polarity.

1992 • 98 citations

Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro

1991 • 98 citations

Frequent Loss of α Catenin Expression in Scirrhous Carcinomas with Scattered Cell Growth

1994 • 97 citations

Cadherins and cadherin-associated molecules in the developing and maturing rat testis.

1994 • 97 citations

Molecular cloning and characterization of B-cadherin, a novel chick cadherin.

1991 • 96 citations

Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro

1993 • 96 citations

Uvomorulin‐catenin complex: Cytoplasmic anchorage of a Ca²⁺‐dependent cell adhesion molecule

1989 • 96 citations

Regional assignment of the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16

1989 • 93 citations

Cloning of the Human α-Catenin cDNA and Its Aberrant mRNA in a Human Cancer Cell Line

1993 • 91 citations

Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer: Biological significance and clinical implications

1993 • 89 citations

Linear organization of the liver cell adhesion molecule L-CAM.

1984 • 87 citations

Altered expression of E-cadherin in gastric cancer tissues and carcinomatous fluid

1992 • 87 citations

Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoral drug concentration

1993 • 85 citations

Characterization of cadherin-4 and cadherin-5 reveals new aspects of cadherins

1994 • 85 citations

Association of Plakoglobin with APC, a Tumor-Suppressor Gene Product, and Its Regulation by Tyrosine Phosphorylation

1994 • 84 citations

Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512)

1987 • 84 citations

Oncogene-induced basement membrane invasiveness in human mammary epithelial cells

1994 • 83 citations

E-cadherin expression in a particular subset of sensory neurons

1992 • 83 citations

Cell binding specificity of mouse r-cadherin and chromosomal mapping of the gene

1993 • 81 citations

The structure of the gene coding for the mouse cell adhesion molecule uvomorulin

1991 • 80 citations

Poorly Differentiated Colon Carcinoma Cell Lines Deficient in α-Catenin Expression Express High Levels of Surface E-cadherin but Lack Ca²⁺-Dependent Cell-Cell Adhesion

1993 • 80 citations

N‐Cadherin Gene Maps to Human Chromosome 18 and Is Not Linked to the E‐Cadherin Gene

1990 • 79 citations

Experimental model for liver metastasis formation using lewis lung tumor

1982 • 79 citations

Isolation of complementary DNA encoding K-cadherin, a novel rat cadherin preferentially expressed in fetal kidney and kidney carcinoma.

1994 • 79 citations

Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer

1994 • 79 citations

Metastatic potential of human colon cancer cell lines: relationship to cellular differentiation and carcinoembryonic antigen production

1992 • 78 citations

Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas.

1992 • 76 citations

The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells.

1991 • 76 citations

Transcriptional Regulation of the Human E-Cadherin Gene in Human Prostate Cancer Cell Lines: Characterization of the Human E-Cadherin Gene Promoter

1994 • 75 citations

E-cadherin: a marker for differentiation and invasiveness in prostatic carcinoma

1993 • 74 citations

Delayed Assembly of Desmosomes in Keratinocytes with Disrupted Classic-Cadherin-Mediated Cell Adhesion by a Dominant Negative Mutant

1995 • 74 citations

Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney disease

1992 • 74 citations

Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas.

1992 • 71 citations

Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor‐infiltrating lymphocytes

1992 • 71 citations

Stimulation of urokinase-type plasminogen activator expression by blockage of E-cadherin-dependent cell-cell adhesion.

1993 • 70 citations

Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells: Possible involvement of plakoglobin

1993 • 69 citations

Mouse αN-Catenin: Two Isoforms, Specific Expression in the Nervous System, and Chromosomal Localization of the Gene

1994 • 69 citations

Decreased expression of E‐cadherin and increased invasive capacity in EBV‐LMP‐transfected human epithelial and murine adenocarcinoma cells

1992 • 69 citations

Genomic structure and chromosomal mapping of the mouse N-cadherin gene.

1992 • 68 citations

E-cadherin in the mature and developing organ of Corti of the mouse

1993 • 68 citations

Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck

2007 • 67 citations

E-cadherin expression in basal cell carcinoma

1994 • 66 citations

The Loss of the Expression of α Catenin, the 102 kD Cadherin Associated Protein, in Central Nervous Tissues during Development

1994 • 64 citations

Genomic organization and chromosomal mapping of the mouse P-cadherin gene

1991 • 64 citations

Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells.

1994 • 63 citations

E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line

1992 • 63 citations

Adhesion molecules and related proteins in Darier's disease and Hailey–Hailey disease

1992 • 62 citations

Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines

1994 • 62 citations

Cultured microvascular endothelial cells (MVEC) differ in cytoskeleton, expression of cadherins and fibronectin matrix A study under the influence of interferon-γ

1993 • 62 citations

Relaxin influences growth, differentiation and cell‐cell adhesion of human breast‐cancer cells in culture

1994 • 60 citations

Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T 47D human breast cancer cell growth

1987 • 60 citations

Estradiol regulates E-cadherin mRNA levels in the surface epithelium of the mouse ovary

1994 • 59 citations

Structure, function, regulation and clinical significance of the 52K pro-cathepsin D secreted by breast cancer cells

1988 • 58 citations

The role of E-cadherin and scatter factor in tumor invasion and cell motility

1991 • 58 citations

Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells.

1994 • 57 citations

The cytoskeleton and associated proteins during cleavage, compaction and blastocyst differentiation in the pig

1993 • 54 citations

The Genes for the Calcium-Dependent Cell Adhesion Molecules P- and E-Cadherin Are Tandemly Arranged in the Human Genome

1994 • 53 citations

Structure of the gene for the liver cell adhesion molecule, L-CAM.

1988 • 52 citations

C‐CAM (cell‐CAM 105) – a member of the growing immunoglobulin superfamily of cell adhesion proteins

1991 • 52 citations

L‐Cam expression in normal, premalignant, and malignant colon mucosa

1992 • 52 citations

The insulin-like growth factor binding proteins (IGFBPs) in human breast cancer

1992 • 51 citations

The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heartin vitro

1989 • 51 citations

Citrus flavonoid effect on tumor invasion and metastasis

1994 • 51 citations

Cadherins and associated proteins.

1991 • 49 citations

Phorbol ester-induced scattering of HT-29 human intestinal cancer cells is associated with down-modulation of E-cadherin

1993 • 48 citations

Regulation of adherens junction protein expression in growth-activated 3T3 cells and in regenerating liver

1992 • 48 citations

Fibroblast growth factor receptors contain a conserved HAV region common to cadherins and influenza strain a hemagglutinins: A role in protein-protein interactions?

1992 • 47 citations

Control of carcinoembryonic antigen gene family expression in a differentiating colon carcinoma cell line, Caco-2.

1991 • 46 citations

Expression of XBcad, a novel cadherin, during oogenesis and early development of Xenopus

1991 • 46 citations

An in vitro model of ovarian epithelial carcinogenesis: Changes in cell‐cell communication and adhesion occurring during neoplastic progression

1993 • 46 citations

Influence of basement membrane molecules on directional migration of human breast cell lines in vitro

1991 • 43 citations

Molecular Cloning of Human E-Cadherin Suggests a Novel Subdivision of the Cadherin Superfamily

1994 • 43 citations

E-cadherins identified in osteoblastic cells: Effects of parathyroid hormone and extracellular calcium on localization

1994 • 42 citations

Purification and sequence of rat extracellular superoxide dismutase B secreted by C6 glioma.

1993 • 41 citations

The gene for the cell adhesion molecule m-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the e-cadherin (uvomorulin) locus in both species

1992 • 40 citations

Anti-Invasive Activity of 3,7-Dimethoxyflavonein Vitro

1994 • 40 citations

Modulation of E‐cadherin expression and morphological phenotype in the intravascular component of adenocarcinomas

1995 • 40 citations

Expression of cell adhesion molecules alpha-2, alpha-5 and alpha-6 integrin, E-cadherin, N-CAM and CD-44 in renal cell carcinomas

1993 • 39 citations

Responses to Wnt signals in vertebrate embryos may involve changes in cell adhesion and cell movement

1993 • 39 citations

The presence of plasmin receptors on three mammary carcinoma MCF-7 sublines

1990 • 39 citations

Isolation of a cDNA clone for the liver cell adhesion molecule (L-CAM).

1985 • 38 citations

Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1)

1994 • 38 citations

Immunohistochemical Analysis of E-Cadherin Expression in Human Colorectal Tumours

1993 • 37 citations

Cell surface localisation and stability of uvomorulin during early mouse development

1993 • 36 citations

Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts

1988 • 35 citations

Expression of E-cadherin, P-cadherin and involucrin by normal and neoplastic keratinocytes in culture

1991 • 35 citations

Assignment of the human β-catenin gene (CTNNB1) to 3p22→p21.3 by fluorescence in situ hybridization

1995 • 35 citations

"Trans-differentiation" from epidermal to mesenchymal/myogenic phenotype is associated with a drastic change in cell-cell and cell-matrix adhesion molecules.

1993 • 34 citations

Abnormal insulin-receptor down regulation and dissociation of down regulation from insulin biological action in cultured human tumor cells.

1987 • 33 citations

Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes

1993 • 33 citations

Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin.

1988 • 31 citations

Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas

1992 • 31 citations

Identification and characterization of autocrine‐motility‐factor‐like activity in oral squamous‐cell‐carcinoma cells

1994 • 29 citations

The anti-invasive flavonoid (+)-catechin binds to laminin and abrogates the effect of laminin on cell morphology and adhesion

1987 • 29 citations

Regulation of urokinase plasminogen activator localization in keratinocytes by calcium ion and E-cadherin

1992 • 28 citations

Molecular prognostic factors in bladder cancer

1994 • 27 citations

Gene mapping on mouse chromosome 8 by interspecific crosses: New data on a linkage group conserved on human chromosome 16q

1989 • 27 citations

Cadherins and cadherin-associated molecules in the developing and maturing rat testis

1994 • 25 citations

Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene

1989 • 24 citations

Modulation of human breast cancer cell adhesion by estrogens and antiestrogens

1989 • 24 citations

Modulation of pp60c-src activity and cellular localization during differentiation of human trophoblast cells in culture

1993 • 23 citations

Disorganization of microfilaments and intermediate filaments interferes with the assembly and stability of desmosomes in MDCK epithelial cells

1993 • 23 citations

Identification of the promoter and a transcriptional enhancer of the gene encoding L-CAM, a calcium-dependent cell adhesion molecule.

1993 • 23 citations

Immunolocalization of E-cadherin in human head and neck cancer.

1995 • 22 citations

The role of the insulin-like growth factors in the nervous system

1992 • 21 citations

Low intracellular pH induces redistribution of fodrin and instabilization of lateral walls in MDCK cells

1992 • 20 citations

Confluence dependent resistance (CDR) to doxorubicin and E-cadherin expression in murine mammary cells

1994 • 20 citations

The loss of E-cadherin mRNA transcripts in rat prostatic tumors is accompanied by increased expression of mRNA transcripts encoding fibronectin and its receptor

1994 • 20 citations

Isolation and characterization of a human pseudogene (CTNNAP1) for αE-catenin (CTNNA1): assignment of the pseudogene to 5q22 and the αE-catenin gene to 5q31

1995 • 19 citations

Retinoids in Embryonic Development^a

1993 • 19 citations

Spatio-temporal distribution of the adherens junction-associated molecules vinculin and talin in the early avian embryo

1990 • 17 citations

Differences of E-cadherin expression levels and patterns in human lung cancer

1994 • 17 citations

Expression of cell adhesion molecule E-cadherin in human arachnoid villi

1992 • 17 citations

Role of the membrane-cytoskeleton in the spatial organization of the Na,K-ATPase in polarized epithelial cells.

1991 • 15 citations

Salt stimulation of serum insulin-like growth factor binding protein activity

1988 • 15 citations

Immunohistochemistry of laminin in early chicken and quail blastoderms

1989 • 15 citations

Visualization of the plasmin receptor on carcinoma cells

1992 • 13 citations

Epigenetic Rules for Expression of Cell Adhesion Molecules During Morphogenesis

2007 • 12 citations

Redistribution of epidermal growth factor receptor as a function of cell density, cell-cell adhesion and calcium in human (A-431) cells

1993 • 12 citations

Injection of Antisense RNA Specific for E-Cadherin Demonstrates That E-Cadherin Facilitates Compaction, the First Differentiative Step of the Mammalian Embryo

1992 • 12 citations

Modulation of specific protein expression in teratocarcinoma cell aggregates by antibodies affecting cell-cell interactions

1985 • 11 citations

Inhibition of tumor implantation at sites of trauma by Arg-Gly-Asp containing proteins and peptides

1992 • 11 citations

Involvement of cell motility in tumor progression.

1993 • 11 citations

Micro‐encapsulation of MDCK‐ras‐e cells prevents loss of E‐cadherin invasion‐suppressor function in vivo

1994 • 11 citations

Characterization of Laminin-Stimulated Adherence and Motility in Tumor Cells

1985 • 11 citations

[Correlation between expression of E-cadherin and metastases in human esophageal cancer: preliminary report].

1990 • 10 citations

Human cell adhesion molecule uvomorulin is differentially expressed in various skin tumors

1993 • 9 citations

[E-cadherin expression and cancer invasion and metastasis].

1993 • 8 citations

Production of immunohistochemical reactivity of mouse anti-epithelial monoclonal antibodies raised against human breast cancer cells.

1990 • 7 citations

[The factors involved in invasive ability of endometrial carcinoma cells].

1994 • 5 citations

Expression of E-cadherin in human gastric carcinomas

1991 • 5 citations

[Correlation between E-cadherin expression and metastasis in human breast cancer: preliminary report].

1992 • 5 citations

Increasing N-CAM-mediated cell-cell adhesion does not reduce invasion of RSV-transformed WC5 rat cerebellar cells

1993 • 4 citations

Local expression of insulin-like growth factors during tissue growth and regeneration

1992 • 4 citations

The historical evolution of concepts of the role of the insulin like growth factors

1992 • 4 citations

[Relationship between E-cadherin and growth pattern of gastric cancer and degree of cell differentiation].

1994 • 2 citations

[Immunohistochemical study on the expression of E-cadherin in normal tissues and squamous cell carcinomas of the uterine cervix].

1992 • 2 citations

Heparan Sulfate Degradation in Tumor Cell Invasion and Neovascularization.

1991 • 1 citations

[Expression of E-cadherin in poorly differentiated carcinomas of human stomach: preliminary report].

1992 • 1 citations