E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

1993 • 1,376 citations

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1993 • 1,360 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.

1993 • 912 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.

1994 • 772 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA

1987 • 752 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin

1991 • 632 citations

Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization

1992 • 562 citations

Plakoglobin: A protein common to different kinds of intercellular adhering junctions

1986 • 508 citations

The 102 kd cadherin-associated protein: Similarity to vinculin and posttranscriptional regulation of expression

1991 • 501 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity

1990 • 444 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

1985 • 429 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

1994 • 406 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.

1992 • 385 citations

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.

1991 • 364 citations

Molecular linkage between cadherins and actin filaments in cell—cell adherens junctions

1992 • 359 citations

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

1994 • 326 citations

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

1994 • 319 citations

Desmosomes and hemidesmosomes

1993 • 310 citations

E-cadherin gene mutations in human gastric carcinomacell lines.

1994 • 288 citations

Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.

1992 • 280 citations

Mutations of the E–cadherin gene in human gynecologic cancers

1994 • 280 citations

Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.

1993 • 249 citations

Identification of a putative cell adhesion domain of uvomorulin.

1985 • 246 citations

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

1992 • 236 citations

Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.

1989 • 223 citations

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

1992 • 222 citations

Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.

1993 • 205 citations

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

1994 • 194 citations

Submembranous junctional plaque proteins include potential tumor suppressor molecules.

1993 • 179 citations

Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos

1993 • 172 citations

Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas.

1993 • 97 citations