In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1993 • 997 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Cadherins in cancer: implications for invasion and metastasis

1993 • 939 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

1988 • 810 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA

1987 • 752 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine II. Mucous cells

1974 • 618 citations

Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.

1989 • 510 citations

A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.

1986 • 510 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity

1990 • 444 citations

Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin.

1989 • 436 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

1985 • 429 citations

Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.

1994 • 405 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.

1991 • 366 citations

Transgenic Mice and Analysis of B-Cell Tolerance

1992 • 362 citations

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

1994 • 326 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

1985 • 286 citations

Paneth cell differentiation in the developing intestine of normal and transgenic mice.

1994 • 261 citations

Apoptosis induced by inhibition of intercellular contact.

1994 • 256 citations

Organization of the actin filament cytoskeleton in the intestinal brush border: a quantitative and qualitative immunoelectron microscope study.

1988 • 246 citations

Identification of a putative cell adhesion domain of uvomorulin.

1985 • 246 citations

Correction of Lethal Intestinal Defect in a Mouse Model of Cystic Fibrosis by Human CFTR

1994 • 241 citations

Maintenance of the macromolecular barrier at cell extrusion sites in intestinal epithelium: Physiological rearrangement of tight junctions

1990 • 237 citations

Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine

1988 • 235 citations

Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin

1992 • 228 citations

A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis

1993 • 226 citations

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

1994 • 223 citations

Classical cadherins

1992 • 217 citations

Microvillus Inclusion Disease: An Inherited Defect of Brush-Border Assembly and Differentiation

1989 • 211 citations

Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.

1993 • 205 citations

Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin.

1993 • 199 citations

Cell migration pathway in the intestinal epithelium: An in situ marker system using mouse aggregation chimeras

1985 • 187 citations

Association of Intestinal Peptide Transport with a Protein Related to the Cadherin Superfamily

1994 • 182 citations

Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium.

1992 • 179 citations

Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine.

1994 • 176 citations

Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant

1994 • 176 citations

Long-term impaired neutrophil migration in mice overexpressing human interleukin-8.

1994 • 171 citations

Demonstration of somatic mutation and colonic crypt clonality by X-linked enzyme histochemistry

1988 • 170 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine IV. Paneth cells

1974 • 169 citations

Cadherin expression is required for the spread of Shigella flexneri between epithelial cells

1994 • 164 citations

Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes.

1988 • 161 citations

Somatic Mutation, Monoclonality and Stochastic Models of Stem Cell Organization in the Intestinal Crypt

1993 • 154 citations

Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages

1994 • 153 citations

Cadherins and catenins: interactions and functions in embryonic development

1994 • 146 citations

Broad spectrum pan-cadherin antibodies, reactive with the C-terminal 24 amino acid residues of N-cadherin

1990 • 138 citations

Expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying Helicobacter pylori infection.

1995 • 132 citations

Use of transgenic mice to map cis-acting elements in the liver fatty acid-binding protein gene (Fabpl) that regulate its cell lineage-specific, differentiation-dependent, and spatial patterns of expression in the gut epithelium and in the liver acinus.

1993 • 124 citations

Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract.

1990 • 115 citations

Tumor-suppressor gene products in cell contacts: the cad herin-APC-armadillo connection

1994 • 115 citations

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.

1993 • 104 citations

Fetal endoderm primarily holds the temporal and positional information required for mammalian intestinal development.

1994 • 100 citations

The kinetics of villus cell populations in the mouse small intestine.

1982 • 93 citations

Cytochalasin B induces cellular DNA fragmentation

1990 • 93 citations

The mouse ileal lipid-binding protein gene: a model for studying axial patterning during gut morphogenesis.

1994 • 90 citations

The use of antibodies to 5-bromo-2'-deoxyuridine for the isolation of DNA sequences containing excision-repair sites.

1984 • 85 citations

Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm.

1994 • 81 citations

Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility.

1994 • 76 citations

Electron Microscopic Observations on the Maintenance of the Tight Junction during Cell Division in the Epithelium of the Mouse Small Intestine.

1992 • 70 citations

Stimulation of urokinase-type plasminogen activator expression by blockage of E-cadherin-dependent cell-cell adhesion.

1993 • 70 citations

Differential perturbations in the morphogenesis of anterior structures induced by overexpression of truncated XB- and N-cadherins in Xenopus embryos.

1994 • 65 citations

Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated.

1993 • 56 citations

Modulation of epithelial morphogenesis and cell fate by cell-to-cell signals and regulated cell adhesion

1993 • 53 citations

Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice.

1994 • 42 citations

Intestinal Cell Membranes

1986 • 41 citations

Simultaneous localization of six antigens in single sections of transgenic mouse intestine using a combination of light and fluorescence microscopy.

1992 • 20 citations

Possible Association of Mucous Blanket Integrity with Postirradiation Colonization Resistance

1985 • 17 citations

T-cell tolerance

1992 • 16 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

1992 • 13 citations

Transgenic Mice And Analysis Of B-Cell Tolerance

1992 • 12 citations