1 MAP Kinases in Mitogenesis and Development

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Structural and Functional Diversity in the FGf Receptor Multigene Family

1992 • 1,262 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Development of the Drosophila retina, a neurocrystalline lattice

1976 • 1,028 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Physiological and Biochemical Aspects of Nervous Integration

1968 • 740 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1992 • 638 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways

1993 • 629 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans

1980 • 567 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

An Unidentified Virus which causes the Rapid Production of Tumours in Mice

1964 • 535 citations

Neuronal differentiation in the Drosophila ommatidium

1987 • 532 citations

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

1993 • 503 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations

1991 • 500 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans

1981 • 494 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

SH2/SH3 signaling proteins

1994 • 457 citations

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1994 • 455 citations

Mesoderm Induction in Amphibians: the Role of TGF-β2-Like Factors

1988 • 452 citations

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

1993 • 451 citations

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

Avian sarcoma virus 17 carries the jun oncogene.

1987 • 445 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

The jun and fos protein families are both required for cell cycle progression in fibroblasts.

1991 • 442 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

A Yeast Protein Similar to Bacterial Two-Component Regulators

1993 • 431 citations

Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C

1990 • 425 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain

1987 • 421 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

1994 • 415 citations

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1990 • 412 citations

Pattern formation during vulval development in C. elegans

1986 • 411 citations

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.

1988 • 404 citations

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

1992 • 400 citations

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

1990 • 397 citations

The gene lin-3 encodes an inductive signal for vulval development in C. elegans

1992 • 392 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

Activation of Raf-1 by 14-3-3 proteins

1994 • 370 citations

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

1991 • 369 citations

The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer

1988 • 367 citations

Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins

1982 • 366 citations

Cell fate in the Drosophila ommatidium

1987 • 363 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

1991 • 344 citations

Sequential protein kinase reactions controlling cell growth and differentiation

1994 • 342 citations

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

1994 • 331 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

The activation of phosphatidylinositol 3-kinase by Ras

1994 • 322 citations

FGF signalling in the early specification of mesoderm in Xenopus

1993 • 319 citations

Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.

1992 • 319 citations

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1994 • 315 citations

Morphologic Responses to a Murine Erythroblastosis Virus<xref ref-type="fn" rid="FN1">2</xref>

1967 • 311 citations

Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase

1994 • 299 citations

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

1989 • 298 citations

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

1991 • 298 citations

The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.

1993 • 297 citations

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.

1994 • 296 citations

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila

1994 • 294 citations

PAC-1: a Mitogen-Induced Nuclear Protein Tyrosine Phosphatase

1993 • 289 citations

A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

1992 • 288 citations

Interaction of the Protein Kinase Raf-1 with 14-3-3 Proteins

1994 • 285 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila

1987 • 279 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

A mesoderm-inducing factor is produced by a Xenopus cell line

1987 • 276 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

1992 • 258 citations

Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.

1988 • 257 citations

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

1982 • 256 citations

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.

1992 • 256 citations

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

1990 • 256 citations

Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye

1991 • 255 citations

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.

1993 • 253 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

1992 • 236 citations

rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo.

1993 • 236 citations

cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein.

1992 • 234 citations

Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.

1992 • 232 citations

The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro

1994 • 231 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

Activators and effectors of ras p21 proteins

1994 • 228 citations

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

1992 • 228 citations

The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.

1994 • 228 citations

Mesoderm induction by activin requires FGF-mediated intracellular signals

1994 • 225 citations

The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

1994 • 219 citations

A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila

1993 • 217 citations

Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669

1991 • 215 citations

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

1994 • 214 citations

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

1994 • 214 citations

Inhibition of Ras-Induced DNA Synthesis by Expression of the Phosphatase MKP-1

1994 • 214 citations

Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine

1983 • 214 citations

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 • 212 citations

Cell-cell interaction in the drosophila retina: The bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development

1988 • 209 citations

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

1991 • 209 citations

Activin-mediated mesoderm induction requires FGF

1994 • 208 citations

Involvement of p21ras in Xenopus mesoderm induction

1992 • 207 citations

Characterization of two cDNAs that encode MAP kinase homologues in Arabidopsis thaliana and analysis of the possible role of auxin in activating such kinase activities in cultured cells

1994 • 205 citations

The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.

1993 • 205 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase.

1993 • 203 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF

1993 • 199 citations

Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis

1990 • 198 citations

A protein kinase gene complements the lytic phenotype of Saccharomyces cerevisiae lyt2 mutants

1991 • 197 citations

A protein kinase from Xenopus eggs specific for ribosomal protein S6.

1985 • 195 citations

The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.

1990 • 192 citations

SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors

1992 • 186 citations

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.

1994 • 185 citations

Requirement of the Drosophila raf homologue for torso function

1989 • 181 citations

cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.

1993 • 179 citations

Receptor tyrosine kinases and their targets

1994 • 177 citations

Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

1991 • 175 citations

Involvement of She in Insulin- and Epidermal Growth Factor-Induced Activation of p21^ras

1994 • 174 citations

Association of p21ras with phosphatidylinositol 3-kinase.

1991 • 174 citations

Structure, Mapping, and Expression of erp, a Growth Factor-Inducible Gene Encoding a Nontransmembrane Protein Tyrosine Phosphatase, and Effect of ERP on Cell Growth

1993 • 174 citations

Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.

1993 • 171 citations

Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.

1991 • 170 citations

Cell lineage in the developing retina of Drosophila

1979 • 169 citations

Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.

1993 • 168 citations

Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.

1990 • 167 citations

lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.

1993 • 167 citations

Phosphoinositide 3-kinase: A new effector in signal transduction?

1991 • 166 citations

SMK1, a developmentally regulated MAP kinase, is required for spore wall assembly in Saccharomyces cerevisiae.

1994 • 164 citations

Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments.

1990 • 164 citations

Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye

1987 • 161 citations

Diverse Mitogenic Agents Induce the Phosphorylation of Two Related 42,000-Dalton Proteins on Tyrosine in Quiescent Chick Cells

1984 • 159 citations

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.

1994 • 158 citations

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1994 • 157 citations

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

1992 • 156 citations

Xwnt-8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm.

1992 • 155 citations

Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase.

1994 • 154 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.

1991 • 151 citations

The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells

1994 • 145 citations

Constitutive activation of Mek1 by mutation of serine phosphorylation sites.

1994 • 145 citations

Presence of basic fibroblast growth factor in the early Xenopus embryo

1989 • 144 citations

Heterogeneous expression of four MAP kinase isoforms in human tissues

1992 • 143 citations

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.

1991 • 143 citations

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

1992 • 143 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rsk^mo‐2

1993 • 141 citations

Involvement of the MAP kinase cascade in Xenopus mesoderm induction.

1995 • 136 citations

Distinct Patterns of Actin Organization Regulated by the Small GTP-binding Proteins Rac and Rho

1992 • 136 citations

ATMPKs: a gene family of plant MAP kinases in Arabidopsis thaliana

1993 • 135 citations

Actin filament organization in activated mast cells is regulated by heterotrimeric and small GTP-binding proteins.

1994 • 135 citations

Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.

1992 • 133 citations

MsERK1: a mitogen-activated protein kinase from a flowering plant.

1993 • 132 citations

Phosphorylation of smooth muscle caldesmon by mitogen-activated protein (MAP) kinase and expression of MAP kinase in differentiated smooth muscle cells

1992 • 131 citations

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

1993 • 129 citations

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

1993 • 128 citations

Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).

1994 • 128 citations

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

1991 • 126 citations

Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.

1985 • 125 citations

The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7

1987 • 124 citations

Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.

1994 • 123 citations

Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.

1992 • 123 citations

RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

1994 • 121 citations

Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611

1984 • 121 citations

Mesoderm-inducing factors in early vertebrate development.

1993 • 120 citations

Shc, Grb2, Sosl, and a 150-Kilodalton Tyrosine-Phosphorylated Protein Form Complexes with Fms in Hematopoietic Cells

1994 • 119 citations

Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation

1993 • 118 citations

Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo.

1994 • 116 citations

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.

1992 • 115 citations

phyllopod functions in the fate determination of a subset of photoreceptors in drosophila

1995 • 114 citations

Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction.

1991 • 113 citations

Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine.

1991 • 113 citations

Regulation of a major microtubule-associated protein by MPF and MAP kinase.

1992 • 112 citations

The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites.

1992 • 111 citations

Evidence for communication between nerve growth factor and protein tyrosine phosphorylation

1990 • 107 citations

The plant homologue of MAP kinase is expressed in a cell cycle‐dependent and organ‐specific manner

1993 • 106 citations

Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases.

1992 • 106 citations

The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

1994 • 106 citations

Control of drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the raf kinase

1995 • 106 citations

Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth.

1993 • 105 citations

Growth factor‐stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

1994 • 104 citations

Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila

1994 • 102 citations

MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity.

1994 • 102 citations

Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase

1986 • 102 citations

Expression of Activin mRNA during Early Development in Xenopus laevis

1993 • 101 citations

EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain.

1991 • 100 citations

Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis.

1991 • 100 citations

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

1993 • 99 citations

Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.

1993 • 99 citations

A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo.

1993 • 98 citations

Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation.

1994 • 97 citations

Genetics of signal transduction in invertebrates

1994 • 96 citations

Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation

1991 • 96 citations

Regulation of the ras signalling network

1994 • 96 citations

A tumor promoter stimulates phosphorylation on tyrosine

1983 • 92 citations

Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells.

1984 • 90 citations

Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus

1992 • 89 citations

Molecular cloning and expression of a MAP kinase homologue from pea

1993 • 86 citations

Isolation and characterization of a tobacco cDNA clone encoding a putative MAP kinase

1993 • 83 citations

Functional divergence of the MAP kinase pathway ERK1 and ERK2 activate specific transcription factors

1994 • 82 citations

Prepattern in the developing Drosophila eye revealed by an activated torso--sevenless chimeric receptor.

1992 • 80 citations

Ubiquitous Expression of sevenless : Position-Dependent Specification of Cell Fate

1989 • 79 citations

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

1992 • 78 citations

SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.

1992 • 74 citations

A pupal lethal mutation with a paternally influenced maternal effect on embryonic development in Drosophila melanogaster

1985 • 74 citations

The Jun and Fos Protein Families Are Both Required for Cell Cycle Progression in Fibroblasts

1991 • 74 citations

A Growth Factor-Induced Kinase Phosphorylates the Serum Response factor at a Site that Regulates its DNA-Binding Activity

1993 • 71 citations

Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila.

1989 • 69 citations

Ommatidia in the developing Drosophila eye require and can respond to sevenless for only a restricted period

1989 • 69 citations

Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.

1994 • 69 citations

Extracellular signal-regulated kinases in T cells: Characterization of human ERK1 and ERK2 cDNAs

1992 • 67 citations

Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis.

1993 • 67 citations

The amino acid sequence of a mammalian MAP kinase kinase.

1992 • 66 citations

Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta.

1994 • 61 citations

pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.

1992 • 61 citations

Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation.

1990 • 60 citations

Identification and Functional Analysis of a Developmentally Regulated Extracellular Signal-Regulated Kinase Gene in Dictyostelium discoideum

1994 • 59 citations

Rapid deactivation of MAP kinase in PC12 cells occurs independently of induction of phosphatase MKP‐1

1994 • 59 citations

Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle

1992 • 58 citations

Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites.

1994 • 57 citations

MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues.

1993 • 55 citations

Synergistic activation by Ras and 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator.

1994 • 55 citations

MAP Kinase Is Activated during Mesoderm Induction in Xenopus laevis

1994 • 54 citations

Cellular responses regulated by rho-related small GTP-binding proteins

1993 • 53 citations

On the Mechanism of Cytosolic Phospholipase A2 Activation in CHO Cells Carrying Somatostatin Receptor: Wortmannin-Sensitive Pathway to Activate Mitogen-Activated Protein Kinase

1994 • 52 citations

Neuronal development in the Drosophila retina: the sextra gene defines an inhibitory component in the developmental pathway of R7 photoreceptor cells.

1992 • 41 citations

Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor

1993 • 40 citations

Purification and characterization of a mitogen-activated protein kinase tyrosine phosphatase from Xenopus eggs.

1993 • 39 citations

Fibroblast growth factor, but not activin, is a potentactivator of mitogen-activated protein kinase in Xenopusexplants.

1994 • 39 citations

Jun Is Phosphorylated by Several Protein Kinases at the Same Sites That Are Modified in Serum-Stimulated Fibroblasts

1992 • 39 citations

Identification and Characterization of a New Mammalian Mitogen-Activated Protein Kinase Kinase, MKK2

1993 • 38 citations

Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein.

1994 • 38 citations

Identification of a latent MAP kinase kinase kinase in PC12 cells as B‐raf

1994 • 37 citations

A purified S6 kinase kinase from Xenopus eggs activates S6 kinase II and autophosphorylates on serine, threonine, and tyrosine residues.

1992 • 31 citations

mip causes hyperinnervation of a retinotopic map in drosophila by excessive recruitment of R7 photoreceptor cells

1992 • 29 citations

Isolation of two members of the rat MAP kinase kinase gene family

1993 • 29 citations

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila

1994 • 26 citations

Cell fate patterning during C. elegans vulval development

1993 • 25 citations

The Drosophila melanogaster ribosomal S6 kinase II-encoding sequence

1994 • 25 citations

Identification of a major maturation-activated acetyl-CoA carboxylase kinase in sea star oocytes as p44mpk

1991 • 25 citations

Insulin-stimulated microtubule associated protein kinase is detectable by analytical gel chromatography as a 35-kDa protein in myocytes, adipocytes, and hepatocytes

1988 • 24 citations

Combinatorial signaling in development

1994 • 23 citations

Mitogen-Activated Protein Kinase Kinase 1 (MKK1) Is Negatively Regulated by Threonine Phosphorylation

1994 • 23 citations

Sequence of a rat cDNA encoding the ERK1-MAP kinase

1992 • 19 citations

Identification of a 42-Kilodalton Phosphotyrosyl Protein as a Serine(Threonine) Protein Kinase by Renaturation

1990 • 17 citations

Signaling mechanisms in induction of the R7 photoreceptor in the developing Drosophila retina

1994 • 15 citations

Interactions of Growth Factor Receptors with Cytoplasmic Signaling Molecules

1991 • 13 citations

The mitogen-activated p70s6k

1992 • 12 citations

Reconstitution of the Raf-1—MEK—ERK Signal Transduction Pathway In Vitro

1994 • 9 citations

Intercellular Signaling during Caenorhabditis elegans Vulval Induction

1992 • 3 citations

Deleted Work

1955 • 0 citations