Immunotherapy Targeting the CD40/CD154 Costimulatory Pathway for Treatment of Autoimmune Disease

CD40-CD40 ligand

2000 • 1,376 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis

1997 • 737 citations

IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

1996 • 653 citations

A short course of BG9588 (anti–CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis

2003 • 592 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

Activation of Monocyte/Macrophage Functions Related to Acute Atheroma Complication by Ligation of CD40

1997 • 493 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

Requirement for CD154 in the progression of atherosclerosis

1999 • 437 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154

1999 • 418 citations

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

1993 • 384 citations

Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.

1995 • 368 citations

Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.

1996 • 360 citations

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice

2000 • 353 citations

Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

1992 • 323 citations

Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype

2000 • 263 citations

A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation

1995 • 252 citations

Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients

2003 • 247 citations

CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice.

1997 • 244 citations

2 å crystal structure of an extracellular fragment of human CD40 ligand

1995 • 240 citations

Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions

2003 • 233 citations

A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex.

1995 • 231 citations

Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice. Response correlates with the absence of an anti-antibody response.

1996 • 220 citations

Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis

1999 • 219 citations

Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions

2003 • 219 citations

The Clinical Course of Experimental Autoimmune Encephalomyelitis and Inflammation Is Controlled by the Expression of Cd40 within the Central Nervous System

2001 • 215 citations

CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM+IgD+ B Cell Line

1998 • 212 citations

Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: nitric oxide production is associated with dendritic cell apoptosis.

1996 • 210 citations

Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.

1999 • 209 citations

Engagement of Glycoprotein IIb/IIIa (α _IIb β ₃ ) on Platelets Upregulates CD40L and Triggers CD40L-Dependent Matrix Degradation by Endothelial Cells

2002 • 205 citations

Anti-CD40 Ligand Antibody Treatment of SNF1 Mice with Established Nephritis: Preservation of Kidney Function

1998 • 202 citations

Recombinant Soluble Trimeric CD40 Ligand Is Biologically Active

1995 • 176 citations

Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation

1999 • 174 citations

Kinetics of Expression of Costimulatory Molecules and Their Ligands in Murine Relapsing Experimental Autoimmune Encephalomyelitis In Vivo

1998 • 169 citations

Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.

1997 • 166 citations

Animal Models of Myasthenia Gravis

2000 • 162 citations

The functional significance of epitope spreading and its regulation by co‐stimulatory molecules

1998 • 162 citations

The effect of anti‐CD40 ligand antibody on B cells in human systemic lupus erythematosus

2002 • 161 citations

CD40L Blockade Prevents Autoimmune Diabetes by Induction of Bitypic NK/DC Regulatory Cells

2002 • 159 citations

Regulation of expression of the ligand for CD40 on T helper lymphocytes.

1993 • 155 citations

Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides

1997 • 154 citations

Ligation of B7 with CD28/CTLA‐4 on T cells results in CD40 ligand expression, interleukin‐4 secretion and efficient help for antibody production by B cells

1993 • 153 citations

Arrest of B Lymphocyte Terminal Differentiation by CD40 Signaling: Mechanism for Lack of Antibody-Secreting Cells in Germinal Centers

1998 • 144 citations

Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.

1994 • 142 citations

Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions

2001 • 135 citations

Membrane-anchored CD40 Is Processed by the Tumor Necrosis Factor-α-converting Enzyme

2003 • 130 citations

Increased soluble and platelet-associated CD40 ligand in essential thrombocythemia and reactive thrombocytosis

2002 • 124 citations

Functional Role of CD40 and Its Ligand

1997 • 123 citations

Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process

2000 • 121 citations

Molecular regulation of CD40 gene expression in macrophages and microglia

2003 • 119 citations

The CD40L Promoter Contains Nuclear Factor of Activated T Cells-binding Motifs Which Require AP-1 Binding for Activation of Transcription

1996 • 119 citations

Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes

2002 • 117 citations

Human Native Soluble CD40L Is a Biologically Active Trimer, Processed Inside Microsomes

1996 • 117 citations

Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura

2003 • 109 citations

The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells.

1996 • 104 citations

The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression

2002 • 98 citations

Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation

2001 • 97 citations

Suppression of murine thyroiditis via blockade of the CD40–CD40L interaction

1997 • 94 citations

B7/CD28-dependent and -independent induction of CD40 ligand expression.

1995 • 91 citations

Effects of anti‐CD154 treatment on B cells in murine systemic lupus erythematosus

2003 • 88 citations

Blockade of CD40 Ligand Suppresses Chronic Experimental Myasthenia Gravis by Down-Regulation of Th1 Differentiation and Up-Regulation of CTLA-4

2001 • 88 citations

Induction, regulation, and function of soluble TRAP (CD40 ligand) during interaction of primary CD4⁺ CD45RA⁺ T cells with dendritic cells

1996 • 87 citations

Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA

2001 • 87 citations

The Human gp39 Promoter

1995 • 86 citations

Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells

1998 • 84 citations

Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis.

1988 • 83 citations

Delineation of a Novel Pathway That Regulates CD154 (CD40 Ligand) Expression

2003 • 82 citations

IL-2 and IL-15 Regulate CD154 Expression on Activated CD4 T Cells

2000 • 79 citations

In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity

2000 • 75 citations

Identification of Residues on CD40 and Its Ligand Which Are Critical for the Receptor-Ligand Interaction

1995 • 74 citations

IL-12 Up-Regulates CD40 Ligand (CD154) Expression on Human T Cells

1998 • 74 citations

Regulation of CD154 (CD40 Ligand) mRNA Stability During T Cell Activation

1999 • 72 citations

Aberrant Expression of the Costimulatory Molecule CD40 Ligand on Monocytes from Patients with Systemic Lupus Erythematosus

2002 • 71 citations

CD40 Expression in Human Thyroid Tissue: Evidence for Involvement of Multiple Cell Types in Autoimmune and Neoplastic Diseases

1999 • 71 citations

Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12)

2002 • 66 citations

alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity.

1997 • 65 citations

Upregulation of CD40–CD40 ligand system in patients with diabetes mellitus

2003 • 64 citations

The role of CD40 ligand and tumor necrosis factor α signaling in the transgenic K/BxN mouse model of rheumatoid arthritis

2000 • 63 citations

CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation

1997 • 61 citations

CD28 co-stimulation stabilizes the expression of the CD40 ligand on T cells

1998 • 61 citations

Cell-cell interactions in synovitis: antigen presenting cells and T cell interaction in rheumatoid arthritis.

2001 • 61 citations

Analysis of gp39/CD40 Interactions Using Molecular Models and Site-Directed Mutagenesis

1995 • 60 citations

Characteristics of Inflammatory Cells in Spontaneous Autoimmune Thyroiditis of NOD.H-2h4 Mice

2001 • 59 citations

Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal disease

2003 • 59 citations

CD40/CD40L Interaction is Essential for the Induction of EAE in the Absence of CD28-Mediated Co-stimulation

2002 • 54 citations

Therapy with antibodies against CD40L (CD154) and CD44-variant isoforms reduces experimental autoimmune encephalomyelitis induced by a proteolipid protein peptide

1998 • 54 citations

Heteromultimeric Complexes of CD40 Ligand Are Present on the Cell Surface of Human T Lymphocytes

1997 • 51 citations

CD40 and its ligand: Central players in B lymphocyte survival, growth, and differentiation

1995 • 51 citations

Characterization of soluble CD40 ligand released from human activated platelets.

2001 • 50 citations

A Complex Containing Polypyrimidine Tract-Binding Protein Is Involved in Regulating the Stability of CD40 Ligand (CD154) mRNA

2003 • 49 citations

Costimulatory Molecules and Autoimmune Thyroid Diseases

2002 • 48 citations

Distinct mechanisms of action of anti‐CD154 in early versus late treatment of murine lupus nephritis

2003 • 48 citations

Differential requirements for CD28 and CD40 ligand in the induction of experimental autoimmune myasthenia gravis

1998 • 48 citations

Helper effector function of human T cells stimulated by anti‐CD3 mAb can be enhanced by co‐stimulatory signals and is partially dependent on CD40‐CD40 ligand interaction

1994 • 47 citations

Prolonged Islet Allograft Survival in Diabetic NOD Mice by Targeting CD45RB and CD154

2003 • 45 citations

Human Endothelial Cells Augment Early CD40 Ligand Expression in Activated CD4+ T Cells Through LFA-3-Mediated Stabilization of mRNA

1999 • 44 citations

A humanized anti-human CD154 monoclonal antibody blocks CD154–CD40 mediated human B cell activation

2001 • 44 citations

Transient anti-CD154-mediated immunotherapy of ongoing relapsing experimental autoimmune encephalomyelitis induces long-term inhibition of disease relapses

2002 • 40 citations

CD40 in Clinical Inflammation: From Multiple Sclerosis to Atherosclerosis

1997 • 39 citations

Requirement of a second signal via protein kinase C or protein kinase A for maximal expression of CD40 ligand. Involvement of transcriptional and posttranscriptional mechanisms

1997 • 38 citations

Co‐Stimulatory Blockade in the Treatment of Murine Systemic Lupus Erythematosus (SLE)

2003 • 36 citations

Functional properties of lymphocytes in idiopathic thrombocytopenic purpura

2001 • 35 citations

Identification of a CD28 Response Element in the CD40 Ligand Promoter

2001 • 30 citations

Identification of a Complex that Binds to the CD154 3′ Untranslated Region: Implications for a Role in Message Stability During T Cell Activation

2000 • 30 citations

A T Cell-specific Enhancer of the Human CD40 Ligand Gene

2002 • 30 citations

Autoimmune Intervention by CD154 Blockade Prevents T Cell Retention and Effector Function in the Target Organ

2001 • 29 citations

Antibodies to Murine CD40 Protect Normal and Malignant B Cells from Induced Growth Arrest

1994 • 28 citations

Characterization of RNA Binding Proteins Associated with CD40 Ligand (CD154) mRNA Turnover in Human T Lymphocytes

1999 • 25 citations

CD40-mediated activation of T cells accelerates, but is not required for, encephalitogenic potential of myelin basic protein-recognizing T cells in a model of progressive experimental autoimmune encephalomyelitis

2001 • 25 citations

Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis

2002 • 23 citations

Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis

2002 • 21 citations

CD154 Variants Associated with Hyper-IgM Syndrome Can Form Oligomers and Trigger CD40-mediated Signals

1999 • 21 citations

Transcriptional Activity of the Distal CD40 Ligand Promoter

2000 • 19 citations

Prolonged survival of allogeneic islet grafts in NOD mice treated with a combination of anti-CD45RB and anti-CD154 antibodies

2001 • 18 citations

CD40L is Critical for Protection from Demyelinating Disease and Development of Spontaneous Remyelination in a Mouse Model of Multiple Sclerosis

2000 • 18 citations

Disruption of CD40/CD40 ligand interaction with cleavage of CD40 on human gingival fibroblasts by human leukocyte elastase resulting in down-regulation of chemokine production

2002 • 17 citations

Cleavage of membrane‐bound CD40 ligand is not required for inducing B cell proliferation and differentiation

1996 • 17 citations

Biophysical Characterization of a Soluble CD40 Ligand (CD154) Coiled-Coil Trimer: Evidence of a Reversible Acid-Denatured Molten Globule

2001 • 17 citations

CD154 Blockade Results in Transient Reduction in Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease

2003 • 15 citations

A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse

2003 • 14 citations

Biologic Agents in the Treatment of Rheumatoid Arthritis

2000 • 14 citations

CD40L is Necessary for the Priming of Effector Cells for Lymphocytic and Granulomatous Experimental Autoimmune Thyroiditis

1999 • 13 citations

Prevention of T-cell activation by rhCTLA4-Ig and anti-CD40L monoclonal antibody results in indefinite islet allograft survival

1999 • 11 citations

Prevention of Autoimmune Diabetes in the DRBB Rat by CD40/154 Blockade

2002 • 11 citations

Expression of CD40 and Apoptosis Related Molecules in Autoimmune Thyroid Diseases

2001 • 10 citations

The anterior medullary velum and its involvement during autoimmune demyelination

1986 • 6 citations

CD154 for the dragon: a promising development for pancreatic islet transplantation and cure for type 1 diabetes mellitus

2000 • 4 citations

Meta-analysis reinforces data on aspirin's benefit in acute ischaemic stroke

2000 • 4 citations

Anti-CD40 allays rheumatoid arthritis in mice

2000 • 3 citations

Myasthenia gravis: selective enrichment of antiacetylcholine receptor antibody production in untransformed human B cell cultures

1999 • 2 citations

Response of Rat Encephalitogenic T Cells to Synthetic Peptides of Guinea Pig Myelin Basic Proteina

1988 • 1 citations