Control of Translation by the Target of Rapamycin Proteins

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1991 • 1,937 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

1975 • 1,605 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

Translational control of gene expression

2000 • 1,371 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

1998 • 1,271 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

1987 • 1,216 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Translational control of gene expression

2001 • 1,192 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

1999 • 928 citations

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

1999 • 918 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1975 • 908 citations

The DNA-dependent protein kinase

1999 • 896 citations

Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP

1996 • 881 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

TOR controls translation initiation and early G1 progression in yeast.

1996 • 728 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

2000 • 713 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development

1999 • 685 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

1997 • 637 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts

1999 • 621 citations

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

1990 • 613 citations

The TOR signaling cascade regulates gene expression in response to nutrients

1999 • 593 citations

DNA end-joining: from yeast to man

1998 • 586 citations

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

1995 • 547 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

1999 • 526 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases.

1996 • 499 citations

Bidirectional modulation of insulin action by amino acids.

1998 • 491 citations

Cap-Dependent Translation Initiation in Eukaryotes Is Regulated by a Molecular Mimic of eIF4G

1999 • 490 citations

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12–rapamycinassociated protein

1999 • 490 citations

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

1997 • 489 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

1994 • 475 citations

Translational control

1991 • 464 citations

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

1977 • 444 citations

The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs

1999 • 434 citations

Mechanism of Action

2002 • 434 citations

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

1994 • 378 citations

Regulation of Ribosome Biogenesis by the Rapamycin-sensitive TOR-signaling Pathway inSaccharomyces cerevisiae

1999 • 378 citations

A Signaling Pathway to Translational Control

1996 • 370 citations

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1990 • 360 citations

Leucine Regulates Translation of Specific mRNAs in L6 Myoblasts through mTOR-mediated Changes in Availability of eIF4E and Phosphorylation of Ribosomal Protein S6

1999 • 356 citations

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

1999 • 339 citations

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

2000 • 338 citations

Activity of rapamycin (AY-22,989) against transplanted tumors.

1984 • 337 citations

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1998 • 331 citations

Topological characteristics of helical repeat protein

1999 • 324 citations

ATM: from gene to function

1998 • 320 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

1998 • 308 citations

The Yeast Phosphatidylinositol Kinase Homolog TOR2 Activates RHO1 and RHO2 via the Exchange Factor ROM2

1997 • 304 citations

FAT: a novel domain in PIK-related kinases

2000 • 300 citations

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

1995 • 298 citations

4E-BP3, a New Member of the Eukaryotic Initiation Factor 4E-binding Protein Family

1998 • 292 citations

FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.

1991 • 292 citations

Coupling of cell division to cell growth by translational control of the G₁ cyclin CLN3 in yeast

1997 • 290 citations

Starvation Induces Vacuolar Targeting and Degradation of the Tryptophan Permease in Yeast

1999 • 289 citations

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

1997 • 281 citations

ATM: A mediator of multiple responses to genotoxic stress

1999 • 274 citations

Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

1993 • 271 citations

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI

2000 • 269 citations

TOR2 is required for organization of the actin cytoskeleton in yeast

1996 • 261 citations

5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes

2000 • 246 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

TOR Mutations Confer Rapamycin Resistance by Preventing Interaction with FKBP12-Rapamycin

1995 • 237 citations

Branched-chain Amino Acids Are Essential in the Regulation of PHAS-I and p70 S6 Kinase by Pancreatic β-Cells

1998 • 236 citations

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.

1995 • 225 citations

Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae

1989 • 220 citations

Rapamycin Induces the G₀ Program of Transcriptional Repression in Yeast by Interfering with the TOR Signaling Pathway

1998 • 214 citations

Rapamycin Sensitivity in Saccharomyces cerevisiae Is Mediated by a Peptidyl-Prolyl cis-trans Isomerase Related to Human FK506-Binding Protein

1991 • 213 citations

B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

1997 • 212 citations

DNA double-strand break repair

1999 • 209 citations

Amino Acid-dependent Control of p70s6k

1999 • 205 citations

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

1993 • 202 citations

Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways

1999 • 197 citations

Identification of Phosphorylation Sites in the Translational Regulator, PHAS-I, That Are Controlled by Insulin and Rapamycin in Rat Adipocytes

1997 • 193 citations

Interaction of RAFT1 with Gephyrin Required for Rapamycin-Sensitive Signaling

1999 • 186 citations

Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation

1999 • 175 citations

The Cln3 cyclin is down-regulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeast

1997 • 175 citations

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

1999 • 175 citations

α4 Associates with Protein Phosphatases 2A, 4, and 6

1998 • 175 citations

The role of ATM in DNA damage responses and cancer

1998 • 165 citations

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

1995 • 165 citations

The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is Activated by Antibodies to a Region near Its COOH Terminus

1997 • 165 citations

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

1998 • 160 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation.

1978 • 159 citations

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.

1991 • 158 citations

FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.

1993 • 149 citations

The FKBP12-Rapamycin-binding Domain Is Required for FKBP12-Rapamycin-associated Protein Kinase Activity and G1 Progression

1999 • 147 citations

Inhibition of T and B lymphocyte proliferation by rapamycin.

1991 • 144 citations

Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue.

1994 • 143 citations

Yeast cyclophilin: isolation and characterization of the protein, cDNA and gene

1989 • 142 citations

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

1994 • 138 citations

The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae

1998 • 137 citations

The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerase.

1990 • 133 citations

Eap1p, a Novel Eukaryotic Translation Initiation Factor 4E-Associated Protein in Saccharomyces cerevisiae

2000 • 131 citations

Proline isomerases function during heat shock.

1993 • 130 citations

13 Translational Control of Ribosomal Protein mRNAs in Eukaryotes

1996 • 124 citations

FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.

1995 • 116 citations

Regulation of Protein Phosphatase 2A Catalytic Activity by alpha4 Protein and Its Yeast Homolog Tap42

1998 • 115 citations

The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes

1999 • 114 citations

Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells.

1996 • 112 citations

Ig Receptor Binding Protein 1 (α4) Is Associated With a Rapamycin-Sensitive Signal Transduction in Lymphocytes Through Direct Binding to the Catalytic Subunit of Protein Phosphatase 2A

1998 • 107 citations

Insulin Mediates Glucose-stimulated Phosphorylation of PHAS-I by Pancreatic Beta Cells

1998 • 106 citations

Translational Homeostasis: Eukaryotic Translation Initiation Factor 4E Control of 4E-Binding Protein 1 and p70 S6 Kinase Activities

1999 • 103 citations

22 Translational Control of TOP mRNAs

2000 • 103 citations

Requirement for Akt (Protein Kinase B) in Insulin-induced Activation of Glycogen Synthase and Phosphorylation of 4E-BP1 (PHAS-1)

1999 • 102 citations

Functional interaction between RAFT1/FRAP/mTOR and protein kinase Cδ in the regulation of cap-dependent initiation of translation

2000 • 102 citations

Control of the Translational Regulators PHAS-I and PHAS-II by Insulin and cAMP in 3T3-L1 Adipocytes

1996 • 99 citations

FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.

1991 • 98 citations

Dissociation of the eukaryotic initiation factor‐4E/4E‐BP1 complex involves phosphorylation of 4E‐BP1 by an mTOR‐associated kinase

1999 • 97 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action.

1979 • 91 citations

Attenuation of Mammalian Target of Rapamycin Activity by Increased cAMP in 3T3-L1 Adipocytes

1998 • 89 citations

Phosphorylation-dependent prolyl isomerization: a novel cell cycle regulatory mechanism

2000 • 83 citations

The effect of the immunosuppressant FK‐506 on alternate pathways of T cell activation

1991 • 82 citations

Protein Kinase Activity and Identification of a Toxic Effector Domain of the Target of Rapamycin TOR Proteins in Yeast

1999 • 81 citations

Nutrients differentially regulate multiple translation factors and their control by insulin

1999 • 78 citations

A Putative Sirolimus (Rapamycin) Effector Protein

1994 • 77 citations

Translational Control of Gene Expression

1995 • 76 citations

Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)

1998 • 70 citations

Insulin and growth factors stimulate the phosphorylation of a Mr-22000 protein in 3T3-L1 adipocytes

1983 • 67 citations

Alpha4 protein as a common regulator of type 2A‐related serine/threonine protein phosphatases¹

1999 • 65 citations

7 DNA-dependent protein kinase and related proteins

1999 • 60 citations

14 Ribosomal Protein S6 Phosphorylation and Signal Transduction

1996 • 59 citations

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs

1994 • 59 citations

Regulation of the Rapamycin and FKBP-Target 1/Mammalian Target of Rapamycin and Cap-dependent Initiation of Translation by the c-Abl Protein-tyrosine Kinase

2000 • 56 citations

CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E

1999 • 51 citations

Preliminary characterization of a heat-stable protein from rat adipose tissue whose phosphorylation is stimulated by insulin

1982 • 45 citations

Distinct Repression of Translation by Wortmannin and Rapamycin

1997 • 44 citations

18 Translational Control by Upstream Open Reading Frames

2000 • 42 citations

The effect of insulin and adrenaline on the phosphorylation of a 22000-molecular weight protein within isolated fat cells; possible identification as the inhibitor-1 of the ‘general phosphatase’

1980 • 35 citations

Dominant Mutations Confer Resistance to the Immunosuppressant, Rapamycin, in Variants of a T Cell Lymphoma

1995 • 34 citations

Reversibility of the insulin-stimulated phosphorylation of ATP citrate lyase and a cytoplasmic protein of subunit Mr 22000 in adipose tissue

1982 • 31 citations

Anti-CD28 antibody- and IL-4-induced human T cell proliferation is sensitive to rapamycin

1993 • 28 citations

Proteins binding to the leader of the 6.0 kb mRNA of human insulin-like growth factor 2 influence translation

1995 • 18 citations

Influence of the Four Leader Sequences of the Human Insulin‐Like‐Growth‐Factor‐2 mRNAs on the Expression of Reporter Genes

1994 • 16 citations

Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells.

1996 • 16 citations

Posttranscriptional regulation of insulin-like growth factor II mRNA.

1995 • 14 citations

FDA approves new immunosuppressants

1999 • 2 citations