RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Basic local alignment search tool

1990 • 87,358 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1991 • 1,937 citations

Fluorescence detection in automated DNA sequence analysis

1986 • 1,694 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

1987 • 1,216 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

Purification and characterization of phosphoinositide 3-kinase from rat liver.

1990 • 640 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

1990 • 613 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

Specification of Subunit Assembly by the Hydrophilic Amino-Terminal Domain of the Shaker Potassium Channel

1992 • 449 citations

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

1977 • 444 citations

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

1993 • 389 citations

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

1994 • 378 citations

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1990 • 360 citations

The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein. Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum.

1993 • 353 citations

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

1990 • 353 citations

Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos

1992 • 348 citations

High brain densities of the immunophilin FKBP colocalized with calcineurin

1992 • 340 citations

Molecular cloning and overexpression of the human FK506-binding protein FKBP

1990 • 316 citations

Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

1993 • 271 citations

Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

1993 • 259 citations

Immunophilins in protein folding and immunosuppression ¹

1994 • 247 citations

Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae

1989 • 220 citations

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

1993 • 202 citations

Internal sequence analysis of proteins separated on polyacrylamide gels at the submicrogram level: Improved methods, applications and gene cloning strategies

1990 • 153 citations

FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.

1993 • 149 citations

Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.

1993 • 143 citations

Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species.

1989 • 136 citations

Examination of automated polypeptide sequencing using standard phenyl isothiocyanate reagent and subpicomole high-performance liquid chromatographic analysis

1989 • 106 citations

Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line.

1993 • 105 citations

Rapid and reliable fluorescent cycle sequencing of double-stranded templates

1992 • 95 citations

Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression.

1992 • 93 citations

FK506 and ciclosporin: molecular probes for studying intracellular signal transduction

1993 • 89 citations

Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25.

1992 • 82 citations

Microbore reversed-phase high-performance liquid chromatographic purification of peptides for combined chemical sequencing-laser-desorption mass spectrometric analysis

1994 • 71 citations

Ciclosporin and its future.

1986 • 61 citations

Size Distribution of Polypeptide Chains in Cells

1970 • 56 citations

Differential induction of primary-response (TIS) genes in PC12 pheochromocytoma cells and the unresponsive variant PC12nnr5.

1991 • 46 citations

Inositol polyphosphates are not increased by overexpression of Ins(1,4,5)P3 3-kinase but show cell-cycle dependent changes in growth factor-stimulated fibroblasts.

1994 • 30 citations

The formation of the Earth

1974 • 23 citations

Combined Edman-Chemical and Laser-Desorption Mass Spectrometric Approaches to Micro Peptide Sequencing: Optimization and Applications

1994 • 21 citations

Successful Peptide Sequencing With Femtomole Level PTH-Analysis: A Commentary

1993 • 18 citations