Neuroimaging and Human Genetics

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Principles of neural science

1982 • 9,410 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

2003 • 8,039 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

A Psychobiological Model of Temperament and Character

1993 • 5,380 citations

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

1996 • 5,154 citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

2003 • 3,746 citations

The amygdala: vigilance and emotion

2000 • 2,823 citations

PRINCIPLES OF NEURAL SCIENCE

1995 • 2,821 citations

Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

Serotonin Transporter Genetic Variation and the Response of the Human Amygdala

2002 • 2,332 citations

A review of MRI findings in schizophrenia

2001 • 2,310 citations

Schizophrenia as a Complex Trait

2003 • 2,253 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

2005 • 1,973 citations

Temporal dynamics of brain activation during a working memory task

1997 • 1,879 citations

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders

1996 • 1,780 citations

Neurobiology of emotion perception II: implications for major psychiatric disorders

2003 • 1,694 citations

Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

2004 • 1,637 citations

Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates.

1992 • 1,566 citations

Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

2000 • 1,565 citations

Discovering the Neural Basis of Human Social Anxiety: A Diagnostic and Therapeutic Imperative

2004 • 1,429 citations

Consciousness and Self-Regulation

1978 • 1,387 citations

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

1996 • 1,320 citations

Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison

2003 • 1,308 citations

Patterns of Brain Activation in People at Risk for Alzheimer's Disease

2000 • 1,282 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

A functional anatomical study of unipolar depression

1992 • 1,266 citations

CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA

1976 • 1,235 citations

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

1995 • 1,152 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Discovering Endophenotypes for Major Depression

2004 • 1,095 citations

A unified biosocial theory of personality and its role in the development of anxiety states.

1986 • 1,090 citations

Genetic influences on brain structure

2001 • 1,054 citations

The human amygdala and the emotional evaluation of sensory stimuli

2003 • 1,046 citations

Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia

1990 • 1,009 citations

Catechol O -methyltransferase val ¹⁵⁸ -met genotype and individual variation in the brain response to amphetamine

2003 • 900 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

A mouse model for Down syndrome exhibits learning and behaviour deficits

1995 • 891 citations

Catechol- O -methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

1998 • 859 citations

Can’t shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals

2002 • 853 citations

Brain development, gender and IQ in children

1996 • 849 citations

MR‐based hippocampal volumetry in the diagnosis of Alzheimer's disease

1992 • 848 citations

Alzheimer's disease: the cholesterol connection

2003 • 843 citations

A Susceptibility Gene for Affective Disorders and the Response of the Human Amygdala

2005 • 819 citations

Physiological Dysfunction of the Dorsolateral Prefrontal Cortex in Schizophrenia Revisited

2000 • 811 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Physiological Characteristics of Capacity Constraints in Working Memory as Revealed by Functional MRI

1999 • 770 citations

Discrimination between Alzheimer Dementia and Controls by Automated Analysis of Multicenter FDG PET

2002 • 768 citations

A decrease of reelin expression as a putative vulnerability factor in schizophrenia

1998 • 757 citations

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

2000 • 745 citations

Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

2001 • 729 citations

Prefrontal Dopamine D₁Receptors and Working Memory in Schizophrenia

2002 • 724 citations

Neurocomputational models of working memory

2000 • 723 citations

Age-related changes in cortical blood flow activation during visual processing of faces and location

1994 • 702 citations

Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter

2004 • 700 citations

Complexity of Prefrontal Cortical Dysfunction in Schizophrenia: More Than Up or Down

2003 • 673 citations

ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA

1974 • 673 citations

Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins

1992 • 665 citations

The emotional counting stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division

1998 • 648 citations

A Functional Polymorphism in the COMT Gene and Performance on a Test of Prefrontal Cognition

2002 • 613 citations

Genes for schizophrenia? Recent findings and their pathophysiological implications

2003 • 610 citations

Physiological Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1988 • 602 citations

Genes, dopamine and cortical signal-to-noise ratio in schizophrenia

2004 • 596 citations

Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naïve patients

1997 • 593 citations

Executive Subprocesses in Working Memory

2003 • 591 citations

Increased Amygdala Activation to Angry and Contemptuous Faces in Generalized Social Phobia

2002 • 586 citations

Lateral Cerebral Ventricular Enlargement in Chronic Schizophrenia

1979 • 579 citations

Apolipoprotein E Type 4 Allele and Cerebral Glucose Metabolism in Relatives at Risk for Familial Alzheimer Disease

1995 • 575 citations

MRI measures of entorhinal cortex vs hippocampus in preclinical AD

2002 • 565 citations

Hippocampal formation glucose metabolism and volume losses in MCI and AD

2001 • 555 citations

METHYLATION PHARMACOGENETICS: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase

1999 • 541 citations

A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety

2004 • 522 citations

Neuroimaging Abnormalities in the Amygdala in Mood Disorders

2003 • 517 citations

Inhibited and Uninhibited Infants "Grown Up": Adult Amygdalar Response to Novelty

2003 • 517 citations

Bidirectional Dopamine Modulation of GABAergic Inhibition in Prefrontal Cortical Pyramidal Neurons

2001 • 511 citations

Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography

1998 • 507 citations

The Functional Neuroanatomy of Target Detection: An fMRI Study of Visual and Auditory Oddball Tasks

1999 • 504 citations

Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: A new hypothesis

1993 • 476 citations

A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity

2000 • 468 citations

Cerebral metabolism and atrophy in huntington's disease determined by ¹⁸FDG and computed tomographic scan

1982 • 449 citations

Abnormal fMRI Response of the Dorsolateral Prefrontal Cortex in Cognitively Intact Siblings of Patients With Schizophrenia

2003 • 447 citations

Glucose metabolism in the amygdala in depression: Relationship to diagnostic subtype and plasma cortisol levels

2002 • 446 citations

Discrimination of Alzheimer's disease and mild cognitive impairment by equivalent EEG sources: a cross-sectional and longitudinal study

2000 • 445 citations

Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects

1997 • 441 citations

PET imaging of amyloid in Alzheimer's disease

2004 • 438 citations

Neuroanatomy of Down’s Syndrome: A High-Resolution MRI Study

2001 • 430 citations

Intelligence and brain structure in normal individuals

1993 • 429 citations

Catechol-O-Methyltransferase Inhibition Improves Set-Shifting Performance and Elevates Stimulated Dopamine Release in the Rat Prefrontal Cortex

2004 • 422 citations

Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia

1992 • 421 citations

Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study

2003 • 401 citations

Onset and rate of striatal atrophy in preclinical Huntington disease

2004 • 393 citations

Cocaine, Ethanol, and Genotype Effects on Human Midbrain Serotonin Transporter Binding Sites and mRNA Levels

1998 • 390 citations

Genetic and Neurochemical Modulation of Prefrontal Cognitive Functions in Children

2004 • 386 citations

Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects

1999 • 385 citations

High Concordance of Bipolar I Disorder in a Nationwide Sample of Twins

2004 • 385 citations

Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia

1999 • 383 citations

Association of Genetic Risks for Schizophrenia and Bipolar DisorderWith Specific and Generic Brain Structural Endophenotypes

2004 • 379 citations

Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates

2002 • 370 citations

Development of the Prefrontal Cortex during Adolescence: Insights into Vulnerable Neural Circuits in Schizophrenia

1997 • 367 citations

Volumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression

2003 • 358 citations

Genes and the parsing of cognitive processes

2004 • 354 citations

Longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type

1988 • 352 citations

The Prefrontal Cortex Regulates Lateral Amygdala Neuronal Plasticity and Responses to Previously Conditioned Stimuli

2003 • 350 citations

3‐Methoxytyramine Is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Simple Two Pool Model

1994 • 349 citations

Genetic variability of human brain size and cortical gyral patterns

1997 • 348 citations

Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?

1998 • 344 citations

Cerebral Blood Flow in Subjects With Social Phobia During Stressful Speaking Tasks: A PET Study

2001 • 340 citations

Occupancy of Serotonin Transporters by Paroxetine and Citalopram During Treatment of Depression: A [¹¹C]DASB PET Imaging Study

2001 • 336 citations

Reduction of Synaptophysin Immunoreactivity in the Prefrontal Cortex of Subjects With Schizophrenia

1997 • 334 citations

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression

2003 • 331 citations

Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world

1992 • 328 citations

Neurocognitive correlates of the COMT Val158Met polymorphism in chronic schizophrenia

2002 • 327 citations

Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain

2003 • 321 citations

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

1997 • 318 citations

Quantitative Genetic Modeling of Variation in Human Brain Morphology

2001 • 318 citations

Reduced Cerebral Glucose Metabolism in Asymptomatic Subjects at Risk for Huntington's Disease

1987 • 309 citations

Ultrastructural Hippocampal and White Matter Alterations in Mild Cognitive Impairment: A Diffusion Tensor Imaging Study

2004 • 305 citations

Prenatal Immune Challenge Disrupts Sensorimotor Gating in Adult Rats Implications for the Etiopathogenesis of Schizophrenia

2002 • 304 citations

Linkage disequilibrium between the beta frequency of the human EEG and a GABA _A receptor gene locus

2002 • 303 citations

Twin and family studies of the human electroencephalogram: a review and a meta-analysis

2002 • 302 citations

Imaging genomics

2003 • 293 citations

The primate serotonergic system: a review of human and animal studies and a report on Macaca fascicularis.

1986 • 289 citations

Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness

2002 • 285 citations

Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report

2000 • 279 citations

The computational role of dopamine D1 receptors in working memory

2002 • 278 citations

Interaction of COMT Val^108/158 Met Genotype and Olanzapine Treatment on Prefrontal Cortical Function in Patients With Schizophrenia

2004 • 277 citations

Electrical potentials of the human brain.

1936 • 271 citations

Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.

1992 • 265 citations

A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart

1995 • 264 citations

Serotonin-Related Gene Polymorphisms and Central Nervous System Serotonin Function

2002 • 263 citations

Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins

2001 • 260 citations

Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography

1992 • 254 citations

Tourette Syndrome: Prediction of Phenotypic Variation in Monozygotic Twins by Caudate Nucleus D2 Receptor Binding

1996 • 250 citations

Brain electrical activity in patients with presenile and senile dementia of the Alzheimer type

1984 • 250 citations

Role of the Serotonin Transporter Promoter Polymorphism in Anxiety-Related Traits

1998 • 248 citations

Consciousness and Self-Regulation

1976 • 247 citations

Novel Radiotracers for Imaging the Serotonin Transporter by Positron Emission Tomography: Synthesis, Radiosynthesis, and in Vitro and ex Vivo Evaluation of ¹¹C-Labeled 2-(Phenylthio)araalkylamines

2000 • 245 citations

Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia

2004 • 244 citations

Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype.

1990 • 241 citations

Episodic memory changes are associated with the APOE- epsilon 4 allele in nondemented older adults

1995 • 235 citations

¹ H NMR spectroscopy studies of Huntington's disease

1998 • 235 citations

Serotonin transporter polymorphism related to amygdala excitability and symptom severity in patients with social phobia

2004 • 231 citations

Auditory-evoked potentials as indicator of brain serotonergic activity first evidence in behaving cats

1997 • 230 citations

Structural Brain Abnormalities in Patients With Schizophrenia and Their Healthy Siblings

2000 • 229 citations

Variation of Human Amygdala Response During Threatening Stimuli as a Function of 5′HTTLPR Genotype and Personality Style

2005 • 228 citations

Genetic and Environmental Sources of Covariation Between Generalized Anxiety Disorder and Neuroticism

2004 • 224 citations

Association Between Serotonin Transporter Gene Promoter Polymorphism(5HTTLPR) and Behavioral Responses to Tryptophan Depletion in Healthy Women With and Without Family History of Depression

2002 • 220 citations

Heritability of human brain functioning as assessed by electroencephalography.

1996 • 220 citations

Reproducibility of fMRI-Determined Language Lateralization in Individual Subjects

2002 • 214 citations

Chronic Overexpression of the Calcineurin Inhibitory Gene DSCR1 (Adapt78)Is Associated with Alzheimer's Disease

2001 • 212 citations

MRI Volumes of the Hippocampus and Amygdala in Adults With Down’s Syndrome With and Without Dementia

1999 • 212 citations

An fMRI study investigating cognitive modulation of brain regions associated with emotional processing of visual stimuli

2003 • 211 citations

Altered P300 Topography in Schizophrenia

1983 • 210 citations

Genetic Contributions to Regional Variability in Human Brain Structure: Methods and Preliminary Results

2002 • 208 citations

Hippocampal Neuron Loss and Memory Scores Before and After Temporal Lobe Surgery for Epilepsy

1993 • 205 citations

When ‘go’ and ‘nogo’ are equally frequent: ERP components and cortical tomography

2004 • 203 citations

Cerebral structure on MRI, part II: Specific changes in Alzheimer's and Huntington's diseases

1991 • 201 citations

Association between serotonin transporter gene polymorphism and anxiety-related traits

1999 • 201 citations

Molecular genetic approach to the characterization of the ?Down syndrome region? of chromosome 21

1989 • 195 citations

A Twin MRI Study of Size Variations in the Human Brain

2000 • 194 citations

Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.

1992 • 191 citations

Sulcal Variability of Twins

1999 • 191 citations

First-Episode Schizophrenic Psychosis Differs From First-Episode Affective Psychosis and Controls in P300 Amplitude Over Left Temporal Lobe

1998 • 189 citations

Schizophrenia: reduced signal-to-noise ratio and impaired phase-locking during information processing

2000 • 186 citations

Genomic Organization, Alternative Splicing, and Expression Patterns of theDSCR1(Down Syndrome Candidate Region 1) Gene

1997 • 184 citations

Heritability of hippocampal size in elderly twin men: Equivalent influence from genes and environment

2001 • 183 citations

SNP association studies in Alzheimer's disease highlight problems for complex disease analysis

2001 • 183 citations

Genetics of the human electroencephalogram (EEG) and event-related brain potentials (ERPs): a review

1994 • 182 citations

Test-Retest Reliability of a Functional MRI Working Memory Paradigm in Normal and Schizophrenic Subjects

2001 • 179 citations

[123I]-β-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder

2000 • 179 citations

Brain catecholamine metabolism in catechol‐O‐methyltransferase (COMT)‐deficient mice

2002 • 178 citations

Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI

2001 • 178 citations

New Evidence of Association Between COMT Gene and Prefrontal Neurocognitive Function in Healthy Individuals From Sibling Pairs Discordant for Psychosis

2004 • 177 citations

Auditory Evoked Potentials Reflect Serotonergic Neuronal Activity—A Study in Behaving Cats Administered Drugs Acting on 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus

1999 • 177 citations

Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome

2001 • 173 citations

In Vivo Association Between Alcohol Intoxication, Aggression, and Serotonin Transporter Availability in Nonhuman Primates

1998 • 173 citations

Association of the G1947A COMT (Val108/158Met) gene polymorphism with prefrontal P300 during information processing

2003 • 173 citations

SNAP-25 deficit and hippocampal connectivity in schizophrenia

1998 • 172 citations

The Relationship between Dorsolateral Prefrontal Neuronal N-Acetylaspartate and Evoked Release of Striatal Dopamine in Schizophrenia

2000 • 170 citations

A Twin Study of the Genetics of Fear Conditioning

2003 • 170 citations

ACTION POTENTIALS OF THE BRAIN

1936 • 170 citations

Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging

2003 • 168 citations

Long-latency event-related potentials in normal aging and dementia.

1982 • 166 citations

Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation

1995 • 159 citations

Regional Neural Dysfunctions in Chronic Schizophrenia Studied With Positron Emission Tomography

2000 • 158 citations

Amygdala and anterior cingulate cortex activation during affective startle modulation: a PET study of fear

2003 • 157 citations

Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics

1993 • 157 citations

Alcoholism and human electrophysiology.

2003 • 156 citations

Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease

1992 • 156 citations

Familial aspects of CT scan abnormalities in chronic schizophrenic patients

1981 • 156 citations

Human fear conditioning is related to dopaminergic and serotonergic biological markers.

2001 • 155 citations

Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease.

2002 • 152 citations

A voxel-based morphometric study of nondemented adults with Down Syndrome

2003 • 152 citations

Cerebral Gray Matter Volume Deficits in First Episode Psychosis

1998 • 151 citations

Specific Relationship Between Prefrontal NeuronalN-Acetylaspartate and Activation of the Working Memory Cortical Network in Schizophrenia

2000 • 151 citations

Alternative phenotypes for the complex genetics of schizophrenia

1999 • 150 citations

Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial

2002 • 149 citations

Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization

2000 • 149 citations

Age‐related cortical grey matter reductions in non‐demented Down’s syndrome adults determined by MRI with voxel‐based morphometry

2004 • 149 citations

Protocols to establish genotype-phenotype correlations in Down syndrome.

1991 • 149 citations

Apolipoprotein E Phenotype and Cognitive Decline in a Prospective Study of Elderly Community Women

1997 • 147 citations

Sensory Information Processing in Neuroleptic-Naive First-Episode Schizophrenic Patients

2002 • 146 citations

Prefrontal Gray Matter Volume Reduction in First Episode Schizophrenia

2001 • 144 citations

Lower Cognitive Performance in Normal Older Adult Male Twins Carrying the Apolipoprotein E 4 Allele

1994 • 144 citations

Serotonin transporter gene polymorphisms are associated with anxiety‐related personality traits in women

2001 • 143 citations

Independent component analysis of fMRI data in the complex domain

2002 • 142 citations

Using magnetic resonance imaging and diffusion tensor imaging to assess brain damage in alcoholics.

2003 • 140 citations

Reduced basal ganglia blood flow and volume in pre-symptomatic, gene-tested persons at-risk for Huntington's disease

1999 • 138 citations

Functional Neuroanatomy of Visuospatial Working Memory in Fragile X Syndrome: Relation to Behavioral and Molecular Measures

2001 • 136 citations

The serotonin transporter gene and peer-rated neuroticism

1997 • 135 citations

Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications

2004 • 133 citations

Short-term memory in Down syndrome: Applying the working memory model

2001 • 132 citations

A pilot Swedish twin study of affective illness including hospital- and population-ascertained subsamples: Results of model fitting

1995 • 132 citations

Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism

1999 • 131 citations

Effects of a Functional COMT Polymorphism on Prefrontal Cognitive Function in Patients With 22q11.2 Deletion Syndrome

2004 • 131 citations

Emotional memory and psychopathology

1997 • 131 citations

Functional MRI studies of word-stem completion: Reliability across laboratories and comparison to blood flow imaging with PET

1998 • 131 citations

Functional neuroimaging of genetic variation in serotonergic neurotransmission

2003 • 130 citations

Genes, Experience, and Chance in Schizophrenia--Positioning for the 21st Century

1997 • 128 citations

Self-Regulation of Stimulus Intensity: Augmenting/Reducing and the Average Evoked Response

1976 • 126 citations

SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele.

1996 • 125 citations

Event-related potentials in psychiatry: differentiating depression and dementia in the elderly.

1982 • 125 citations

Electrophysiological measurements of anterior cingulate function

2002 • 124 citations

Central Serotonin Transporter Availability Measured With [¹²³I]β-CIT SPECT in Relation to Serotonin Transporter Genotype

2004 • 121 citations

Human fear conditioning is related to dopaminergic and serotonergic biological markers.

2001 • 120 citations

Planning ability in Parkinson's disease is influenced by the COMT val¹⁵⁸met polymorphism

2004 • 119 citations

Functional and effective frontotemporal connectivity and genetic risk for schizophrenia

2003 • 118 citations

Genetics of human prefrontal function

2003 • 118 citations

Cortical gray matter volume deficit in patients with first-episode schizophrenia

1996 • 118 citations

Allelic Variation of Serotonin Transporter Function Modulates the Brain Electrical Response for Error Processing

2004 • 117 citations

Biochemistry of the Augmenting-Reducing Response in Visual Evoked Potentials

1981 • 115 citations

Specificity of Brain Activation Patterns in People at Genetic Risk for Alzheimer Disease

2002 • 115 citations

Interaction of COMT Val108/158 Met Genotype and Olanzapine Treatment on Prefrontal Cortical Function in Patients With Schizophrenia

2004 • 114 citations

Gender differences in association between serotonin transporter gene polymorphism and personality traits

2000 • 113 citations

Brain Volumes and Surface Morphology in Monozygotic Twins

2002 • 113 citations

Supra-regional Brain Systems and the Neuropathology of Schizophrenia

1999 • 112 citations

P300 and Genetic Risk for Schizophrenia

2003 • 111 citations

Genetic regulation of regional microstructure of the corpus callosum in late life

2001 • 109 citations

Selective Relationship Between PrefrontalN-Acetylaspartate Measures and Negative Symptoms in Schizophrenia

2000 • 104 citations

Association of Apo E Polymorphism With Plasma Lipid Levels in a Multiethnic Elderly Population

1997 • 103 citations

Links Between the Pathology of Alzheimer's Disease and Vascular Dementia

2004 • 101 citations

The Genetics of Mental Disorders

1972 • 99 citations

The use of positron emission tomography in the clinical assessment of dementia

1992 • 98 citations

Benefits and pitfalls encountered in psychiatric genetic association studies

1999 • 97 citations

Essentials of Clinical Psychopharmacology

2006 • 97 citations

Down syndrome: MR quantification of brain structures and comparison with normal control subjects.

1991 • 94 citations

Neuroticism and polymorphisms in the serotonin transporter gene

1999 • 94 citations

Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders

1998 • 92 citations

Topography of the quantitative electroencephalogram in dementia of the alzheimer type: Relation to severity of dementia

1991 • 92 citations

Magnetic resonance imaging morphology of the corpus callosum in monozygotic twins

1989 • 91 citations

Brain size does not predict general cognitive ability within families

2000 • 90 citations

Reduced regional cerebral blood flow in Huntington's disease studied by SPECT.

1992 • 89 citations

Neuronal and glial metabolite content of the epileptogenic human hippocampus

2002 • 88 citations

Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine

2000 • 86 citations

Language lateralization in monozygotic twin pairs concordant and discordant for handedness

2002 • 86 citations

Prefrontal cortical thickness in first-episode psychosis: a magnetic resonance imaging study

2004 • 85 citations

High Concordance of Bipolar I Disorder in a Nationwide Sample of Twins

2004 • 84 citations

Language activation in monozygotic twins discordant for schizophrenia

2004 • 83 citations

Stability of [123I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humans

1999 • 82 citations

Segregation analysis reveals evidence of a major gene for Alzheimer disease.

1991 • 81 citations

Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion

2002 • 81 citations

Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function1Published on the World Wide Web on 24 October 1997.1

1998 • 79 citations

Genetic Susceptibility to Multiple Sclerosis

1988 • 79 citations

Molecular Cloning of a Novel Thyroid Hormone-responsive Gene, , in Human Skin Fibroblasts

1996 • 78 citations

Kinetic Analysis of [¹¹C]McN5652: A Serotonin Transporter Radioligand

1999 • 78 citations

Mapping the Gene for Juvenile Myoclonic Epilepsy

1989 • 76 citations

Surface Area of Human Cerebral Cortex and Its Gross Morphological Subdivisions:In VivoMeasurements in Monozygotic Twins Suggest Differential Hemisphere Effects of Genetic Factors

1995 • 75 citations

Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.

1997 • 75 citations

Size of the human corpus callosum is genetically determined: an MRI study in mono and dizygotic twins

2003 • 74 citations

Serotonin transporter promoter polymorphism influences topography of inhibitory motor control

1999 • 73 citations

Genetic and environmental influences on EEG coherence.

1998 • 73 citations

Structural Brain MRI Abnormalities in Healthy Siblings of Patients With Childhood-Onset Schizophrenia

2003 • 72 citations

Morphological changes in aging brain structures are differentially affected by time-linked environmental influences despite strong genetic stability

2003 • 71 citations

Frontotemporal neural systems in bipolar disorder

2002 • 69 citations

Six-month test-retest reliability of MRI-defined PET measures of regional cerebral glucose metabolic rate in selected subcortical structures

2000 • 68 citations

Reproducibility of iodine-123-beta-CIT SPECT brain measurement of dopamine transporters.

1996 • 67 citations

Reduction in TrkA‐Immunoreactive Neurons Is Not Associated with an Overexpression of Galaninergic Fibers Within the Nucleus Basalis in Down's Syndrome

2000 • 66 citations

Allelic Variants of the Functional Promoter Polymorphism of the Human Serotonin Transporter Gene is Associated with Auditory Cortical Stimulus Processing

2002 • 65 citations

Multi-dimensional criteria for the diagnosis of depression

2001 • 65 citations

Improved Signal-to-Noise Ratio in Parametric Images by Cluster Analysis

1999 • 64 citations

Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis

2001 • 64 citations

Relationship between Cortisol and Serotonin Metabolites and Transporters in Alcolholism

2002 • 62 citations

Template-Based Method for Multiple Volumes of Interest of Human Brain PET Images

2002 • 61 citations

Genetics of Mental Disorders

2002 • 60 citations

Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaign

2002 • 59 citations

The degree of depression in Hamilton rating scale is correlated with the density of presynaptic serotonin transporters in 23 patients with Wilson's disease

2003 • 58 citations

Atrophy of the Hippocampal Formation in Early Familial Alzheimer's Disease

1996 • 58 citations

Sex Differences in Cerebral Tissue Volume and Cognitive Performance during Adolescence

2002 • 58 citations

Individual differences in P300 amplitude: a genetic study in adolescent twins

1998 • 58 citations

Positron emission computed tomography in the diagnosis of dementia.

1981 • 56 citations

Evoked potentials in subjects at risk for Alzheimer's Disease

1995 • 56 citations

Brain potentials and lateral dominance in identical twins.

1939 • 54 citations

Down syndrome and mouse models

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