The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells.

1990 • 260 citations

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.

1985 • 257 citations

NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene.

1990 • 205 citations

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1993 • 201 citations

Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes.

1989 • 191 citations

T-Cell Activation Signals and Human T-Cell Leukemia Virus Type I-Encoded p40^x Protein Activate the Mouse Granulocyte-Macrophage Colony-Stimulating Factor Gene Through a Common DNA Element

1988 • 171 citations

Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene.

1988 • 129 citations

ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.

1988 • 117 citations

Encounters with Fos and Jun on the road to AP-1.

1990 • 107 citations

Magnetic DNA affinity purification of yeast transcription factor τ—a new purification principle for the ultrarapid isolation of near homogeneous factor

1989 • 104 citations

Rapid test forin vivostability and DNA binding of mutated octamer binding proteins with ‘mini extracts’, prepared from a transfected cells

1989 • 91 citations

Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5.

1991 • 87 citations

Transcriptional regulation of interleukin 3 gene expression in T lymphocytes.

1990 • 87 citations

Positive and negative elements regulate human interleukin 3 expression.

1990 • 87 citations

Characterization of the human granulocyte-macrophage colony-stimulating factor promoter region by genetic analysis: correlation with DNase I footprinting.

1988 • 69 citations

Transcriptional regulation of cytokine genes in nontransformed T cells. Apparent constitutive signals in run-on assays can be caused by repeat sequences.

1991 • 56 citations

The repeated sequence CATT(A/T) is required for granulocyte-macrophage colony-stimulating factor promoter activity.

1990 • 49 citations

Bovine papilloma virus encoded E2 protein activates lymphokine genes through DNA elements, distinct from the consensus motif, in the long control region of its own genome.

1989 • 37 citations

Human interleukin-3 mRNA accumulation is controlled at both the transcriptional and posttranscriptional level

1991 • 31 citations

Inducible and non-inducible factors co-operatively activate the GM-CSF promoter by interacting with adjacent DNA motifs

1990 • 31 citations

A nuclear factor NF-GM2 that interacts with a regulatory region of the GM-CSF gene essential for its induction in response to T-cell activation: purification from human T-cell leukemia line Jurkat cells and similarity to NF-_χB

1991 • 27 citations

Activation of lymphokine genes in T cells: Role of cis-acting DNA elements that respond to T cell activation signals

1992 • 26 citations

Shift from posttranscriptional to predominant transcriptional control of the expression of the GM-CSF gene during activation of human Jurkat cells.

1992 • 9 citations