N-Glycan processing and glycoprotein folding

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

Synthesis and Processing of Asparagine-Linked Oligosaccharides

1981 • 1,403 citations

Setting the Standards: Quality Control in the Secretory Pathway

1999 • 1,198 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control.

1994 • 815 citations

Calreticulin: one protein, one gene, many functions

1999 • 726 citations

Roles for Calreticulin and a Novel Glycoprotein, Tapasin, in the Interaction of MHC Class I Molecules with TAP

1996 • 697 citations

UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS

1998 • 617 citations

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase

1987 • 569 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum

1995 • 544 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

The endoplasmic reticulum Ca2+ store: a view from the lumen

1998 • 522 citations

Calreticulin Is Essential for Cardiac Development

1999 • 509 citations

Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane.

1993 • 443 citations

The Molecular Chaperone Calnexin Binds Glc1Man9GlcNAc2 Oligosaccharide as an Initial Step in Recognizing Unfolded Glycoproteins

1995 • 417 citations

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

1995 • 402 citations

Interaction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins

1997 • 387 citations

The role of lipid intermediates in the glycosylation of proteins in the eucaryotic cell

1979 • 378 citations

Calnexin, calreticulin and the folding of glycoproteins

1997 • 377 citations

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1999 • 371 citations

Degradation of Misfolded Endoplasmic Reticulum Glycoproteins in Saccharomyces cerevisiae Is Determined by a Specific Oligosaccharide Structure

1998 • 344 citations

Chaperone Selection During Glycoprotein Translocation into the Endoplasmic Reticulum

2000 • 331 citations

Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57

1998 • 329 citations

Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells

1999 • 317 citations

Folding of VSV G Protein: Sequential Interaction with BiP and Calnexin

1994 • 316 citations

ERp57 Functions as a Subunit of Specific Complexes Formed with the ER Lectins Calreticulin and Calnexin

1999 • 315 citations

Recognition of the oligosaccharide and protein moieties of glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase

1992 • 313 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

Interactions of misfolded influenza virus hemagglutinin with binding protein (BiP).

1989 • 312 citations

The endoplasmic reticulum as a protein-folding compartment

1992 • 296 citations

Calnexin and calreticulin promote folding, delay oligomerization and suppress degradation of influenza hemagglutinin in microsomes.

1996 • 288 citations

Definition of the Lectin-like Properties of the Molecular Chaperone, Calreticulin, and Demonstration of Its Copurification with Endomannosidase from Rat Liver Golgi

1996 • 280 citations

The putative chaperone calmegin is required for sperm fertility

1997 • 277 citations

Transient, lectin-like association of calreticulin with folding intermediates of cellular and viral glycoproteins.

1995 • 274 citations

The molecular basis for the recognition of misfolded glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase.

1995 • 268 citations

Endoplasmic Reticulum Glucosidase II Is Composed of a Catalytic Subunit, Conserved from Yeast to Mammals, and a Tightly Bound Noncatalytic HDEL-containing Subunit

1996 • 261 citations

Calreticulin Functions as a Molecular Chaperone in the Biosynthesis of Myeloperoxidase

1995 • 260 citations

Oligosaccharide Binding Characteristics of the Molecular Chaperones Calnexin and Calreticulin

1998 • 260 citations

Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

1992 • 259 citations

The Number and Location of Glycans on Influenza Hemagglutinin Determine Folding and Association with Calnexin and Calreticulin

1997 • 258 citations

The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures.

1979 • 255 citations

ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase.

1990 • 254 citations

Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins

1999 • 251 citations

Retention of Unassembled Components of Integral Membrane Proteins by Calnexin

1994 • 243 citations

Topography of glycosylation reactions in the endoplasmic reticulum

1992 • 237 citations

ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly

1998 • 237 citations

Oligosaccharide Modification in the Early Secretory Pathway Directs the Selection of a Misfolded Glycoprotein for Degradation by the Proteasome

1999 • 235 citations

Lectins as chaperones in glycoprotein folding

1998 • 233 citations

Novel Aspects of Degradation of T Cell Receptor Subunits from the Endoplasmic Reticulum (ER) in T Cells: Importance of Oligosaccharide Processing, Ubiquitination, and Proteasome-dependent Removal from ER Membranes

1998 • 218 citations

Interactions between Newly Synthesized Glycoproteins, Calnexin and a Network of Resident Chaperones in the Endoplasmic Reticulum

1997 • 218 citations

The molecular chaperone calnexin facilitates folding and assembly of class I histocompatibility molecules.

1996 • 201 citations

Conformation-Independent Binding of Monoglucosylated Ribonuclease B to Calnexin

1997 • 195 citations

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

1997 • 190 citations

The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex

1998 • 188 citations

Quality Control in the Secretory Pathway: The Role of Calreticulin, Calnexin and BiP in the Retention of Glycoproteins with C-Terminal Truncations

1997 • 187 citations

A pathway for targeting soluble misfolded proteins to the yeast vacuole.

1996 • 178 citations

Comparative rates of transfer of lipid-linked oligosaccharides to endogenous glycoprotein acceptors in vitro.

1977 • 173 citations

Glycan-dependent and -independent Association of Vesicular Stomatitis Virus G Protein with Calnexin

1996 • 165 citations

Purification to apparent homogeneity and partial characterization of rat liver UDP-glucose:glycoprotein glucosyltransferase.

1992 • 165 citations

The 170-kDa glucose-regulated stress protein is an endoplasmic reticulum protein that binds immunoglobulin.

1993 • 163 citations

X-ray Crystal Structure of the Soybean Agglutinin Cross-Linked with a Biantennary Analog of the Blood Group I Carbohydrate Antigen

1995 • 161 citations

The glucose-regulated protein grp94 is related to heat shock protein hsp90

1987 • 161 citations

Calnexin Discriminates between Protein Conformational States and Functions as a Molecular Chaperone In Vitro

1999 • 158 citations

Glucosylation of glycoproteins by mammalian, plant, fungal, and trypanosomatid protozoa microsomal membranes

1989 • 155 citations

Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.

1980 • 153 citations

Quality control in the endoplasmic reticulum: folding and misfolding of vesicular stomatitis virus G protein in cells and in vitro.

1990 • 153 citations

Chaperone Function of Calreticulin When Expressed in the Endoplasmic Reticulum as the Membrane-anchored and Soluble Forms

1995 • 153 citations

Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes.

1984 • 150 citations

N-linked oligosaccharides are necessary and sufficient for association of glycosylated forms of bovine RNase with calnexin and calreticulin.

1996 • 149 citations

Differential Interaction of Coagulation Factor VIII and Factor V with Protein Chaperones Calnexin and Calreticulin

1998 • 148 citations

Glycoprotein folding in the endoplasmic reticulum: a tale of three chaperones?

2000 • 147 citations

A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules

1998 • 144 citations

N-Glycosylation in trypanosomatid protozoa

1993 • 143 citations

Recognition of local glycoprotein misfolding by the ER folding sensor UDP-glucose:glycoprotein glucosyltransferase.

2000 • 141 citations

Evidence for successive peptide binding and quality control stages during MHC class I assembly

1998 • 140 citations

N-glycosylation affects endoplasmic reticulum degradation of a mutated derivative of carboxypeptidase yscY in yeast

1996 • 139 citations

The Yeast KRE5 Gene Encodes a Probable Endoplasmic Reticulum Protein Required for (1→6)-β-D-Glucan Synthesis and Normal Cell Growth

1990 • 136 citations

Calreticulin Interacts with Newly Synthesized Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, Suggesting a Chaperone Function Similar to That of Calnexin

1996 • 134 citations

Calnexin Recognizes Carbohydrate and Protein Determinants of Class I Major Histocompatibility Complex Molecules

1995 • 129 citations

Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: Evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion

1997 • 129 citations

The Mechanism Underlying Cystic Fibrosis Transmembrane Conductance Regulator Transport from the Endoplasmic Reticulum to the Proteasome Includes Sec61β and a Cytosolic, Deglycosylated Intermediary

1998 • 125 citations

The Thiol-dependent Reductase ERp57 Interacts Specifically with N-Glycosylated Integral Membrane Proteins

1997 • 125 citations

Mutations at Critical N-Glycosylation Sites Reduce Tyrosinase Activity by Altering Folding and Quality Control

2000 • 123 citations

Calreticulin and Calnexin Interact with Different Protein and Glycan Determinants During the Assembly of MHC Class I

1998 • 121 citations

Processing by Endoplasmic Reticulum Mannosidases Partitions a Secretion-impaired Glycoprotein into Distinct Disposal Pathways

2000 • 120 citations

Human, Mouse, and Rat Calnexin cDNA Cloning: Identification of Potential Calcium Binding Motifs and Gene Localization to Human Chromosome 5

1994 • 119 citations

Persistence of glucose residues on core oligosaccharides prevents association of TCR alpha and TCR beta proteins with calnexin and results specifically in accelerated degradation of nascent TCR alpha proteins within the endoplasmic reticulum.

1994 • 117 citations

Purification to homogeneity of UDP-glucose:glycoprotein glucosyltransferase from Schizosaccharomyces pombe and apparent absence of the enzyme fro Saccharomyces cerevisiae.

1994 • 116 citations

A Pituitary N -Acetylgalactosamine Transferase That Specifically Recognizes Glycoprotein Hormones

1988 • 113 citations

N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120

1996 • 113 citations

A lectin-resistant mouse lymphoma cell line is deficient in glucosidase II, a glycoprotein-processing enzyme.

1982 • 110 citations

MHC class I expression and transport in a calnexin-deficient cell line.

1995 • 108 citations

Assembly, sorting, and exit of oligomeric proteins from the endoplasmic reticulum

1998 • 108 citations

Functional Relationship between Calreticulin, Calnexin, and the Endoplasmic Reticulum Luminal Domain of Calnexin

2000 • 106 citations

Folding of Insulin Receptor Monomers Is Facilitated by the Molecular Chaperones Calnexin and Calreticulin and Impaired by Rapid Dimerization

1998 • 105 citations

Drosophila UDP-glucose:glycoprotein glucosyltransferase: sequence and characterization of an enzyme that distinguishes between denatured and native proteins.

1995 • 105 citations

Inhibition of Glucose Trimming with Castanospermine Reduces Calnexin Association and Promotes Proteasome Degradation of the α-Subunit of the Nicotinic Acetylcholine Receptor

1998 • 103 citations

Conformational Requirements for Glycoprotein Reglucosylation in the Endoplasmic Reticulum

2000 • 102 citations

Topography of glycosylation reactions in the rough endoplasmic reticulum membrane.

1986 • 99 citations

Two Homologues Encoding Human UDP-Glucose:Glycoprotein Glucosyltransferase Differ in mRNA Expression and Enzymatic Activity

2000 • 99 citations

The solution NMR structure of glucosylated N-glycans involved in the early stages of glycoprotein biosynthesis and folding

1997 • 95 citations

Molecular Requirements for the Interaction of Class II Major Histocompatibility Complex Molecules and Invariant Chain with Calnexin

1995 • 95 citations

Demonstration that a kifunensine-resistant alpha-mannosidase with a unique processing action on N-linked oligosaccharides occurs in rat liver endoplasmic reticulum and various cultured cells.

1993 • 95 citations

Competition between folding and glycosylation in the endoplasmic reticulum.

1996 • 94 citations

Glycoprotein reglucosylation and nucleotide sugar utilization in the secretory pathway: identification of a nucleoside diphosphatase in the endoplasmic reticulum

1999 • 92 citations

Peptides Glycosylated in the Endoplasmic Reticulum of Yeast Are Subsequently Deglycosylated by a Soluble Peptide: N-Glycanase Activity

1998 • 91 citations

Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin

1997 • 90 citations

Evidence that transient glucosylation of protein-linked Man9GlcNAc2, Man8GlcNAc2, and Man7GlcNAc2 occurs in rat liver and Phaseolus vulgaris cells.

1984 • 89 citations

Genetic Evidence for the Heterodimeric Structure of Glucosidase II

1999 • 89 citations

Genetic tailoring of N-linked oligosaccharides: The role of glucose residues in glycoprotein processing of Saccharomyces cerevisiae in vivo

1998 • 87 citations

Glycoprotein biosynthesis in Saccharomyces cerevisiae. Purification of the alpha-mannosidase which removes one specific mannose residue from Man9GlcNAc.

1988 • 87 citations

Inhibition of glucose trimming by castanospermine results in rapid degradation of unassembled major histocompatibility complex class I molecules.

1993 • 86 citations

Calnexin Fails to Associate with Substrate Proteins in Glucosidase-deficient Cell Lines

1995 • 86 citations

A new stress protein: synthesis of Schizosaccharomyces pombe UDP-Glc:glycoprotein glucosyltransferase mRNA is induced by stress conditions but the enzyme is not essential for cell viability.

1996 • 86 citations

Trypanosoma cruziCalreticulin Is a Lectin That Binds Monoglucosylated Oligosaccharides but Not Protein Moieties of Glycoproteins

1999 • 85 citations

The Role of ERp57 in Disulfide Bond Formation during the Assembly of Major Histocompatibility Complex Class I in a Synchronized Semipermeabilized Cell Translation System

2000 • 84 citations

Glucosidase and Mannosidase Inhibitors Mediate Increased Secretion of Mutant α1 Antitrypsin Z

2000 • 84 citations

Tyrosinase Folding and Copper Loading in Vivo: A Crucial Role for Calnexin and α-Glucosidase II

1999 • 84 citations

Transient glucosylation of protein-bound Man9GlcNAc2, Man8GlcNAc2, and Man7GlcNAc2 in calf thyroid cells. A possible recognition signal in the processing of glycoproteins.

1983 • 84 citations

Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin–class I–TAP complexes

1996 • 81 citations

Inhibition of N-Glycan Processing in B16 Melanoma Cells Results in Inactivation of Tyrosinase but Does Not Prevent Its Transport to the Melanosome

1997 • 81 citations

The UDP-Glc:Glycoprotein Glucosyltransferase Is Essential for Schizosaccharomyces pombe Viability under Conditions of Extreme Endoplasmic Reticulum Stress

1998 • 80 citations

Degradation of a Short-lived Glycoprotein from the Lumen of the Endoplasmic Reticulum: The Role of N-linked Glycans and the Unfolded Protein Response

1999 • 79 citations

Calnexin: a molecular chaperone with a taste for carbohydrate

1995 • 79 citations

Calnexin-dependent Enhancement of Nicotinic Acetylcholine Receptor Assembly and Surface Expression

1997 • 78 citations

The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth.

1990 • 78 citations

Transfer of Free Polymannose-type Oligosaccharides from the Cytosol to Lysosomes in Cultured Human Hepatocellular Carcinoma HEPG2 Cells

1997 • 77 citations

Trimming and Readdition of Glucose to N-Linked Oligosaccharides Determines Calnexin Association of a Substrate Glycoprotein in Living Cells

1999 • 77 citations

Pre-Golgi degradation of yeast prepro-alpha-factor expressed in a mammalian cell. Influence of cell type-specific oligosaccharide processing on intracellular fate

1993 • 76 citations

Cytosol-to-lysosome Transport of Free Polymannose-type Oligosaccharides

1999 • 73 citations

Kinetics and the Mechanism of Interaction of the Endoplasmic Reticulum Chaperone, Calreticulin, with Monoglucosylated (Glc1Man9GlcNAc2) Substrate

2000 • 71 citations

Cloning and characterization of mammalian UDP-glucose glycoprotein: glucosyltransferase and the development of a specific substrate for this enzyme

2000 • 70 citations

The Related Molecular Chaperones Calnexin and Calreticulin Differentially Associate with Nascent T Cell Antigen Receptor Proteins within the Endoplasmic Reticulum

1996 • 70 citations

Promotion of Tyrosinase Folding in Cos 7 Cells by Calnexin

1999 • 69 citations

Ligand recognition and domain structure of Vps10p, a vacuolar protein sorting receptor in Saccharomyces cerevisiae

1999 • 68 citations

Retention of glucose units added by the UDP-GLC:glycoprotein glucosyltransferase delays exit of glycoproteins from the endoplasmic reticulum.

1995 • 66 citations

Distinct Patterns of Folding and Interactions with Calnexin and Calreticulin in Human Class I MHC Proteins with Altered N-Glycosylation

1998 • 63 citations

Protein glycosylation in Trypanosoma cruzi. The mechanism of glycosylation and structure of protein-bound oligosaccharides.

1983 • 60 citations

Pivotal Role of Calnexin and Mannose Trimming in Regulating the Endoplasmic Reticulum-associated Degradation of Major Histocompatibility Complex Class I Heavy Chain

2000 • 60 citations

Selective retention of monoglucosylated high mannose oligosaccharides by a class of mutant vesicular stomatitis virus G proteins.

1989 • 59 citations

Unique Expression of Major Histocompatibility Complex Class I Proteins in the Absence of Glucose Trimming and Calnexin Association

1995 • 58 citations

Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association.

1995 • 57 citations

A major proportion of N-glycoproteins are transiently glucosylated in the endoplasmic reticulum

1991 • 54 citations

A novel glycosylation phenotype expressed by Lec23, a Chinese hamster ovary mutant deficient in alpha-glucosidase I.

1991 • 53 citations

Post-translational protein modification in the endoplasmic reticulum. Demonstration of fatty acylase and deoxymannojirimycin-sensitive alpha-mannosidase activities.

1988 • 53 citations

Glycoprotein synthesis in yeast. Early events in N-linked oligosaccharide processing in Schizosaccharomyces pombe.

1994 • 52 citations

Protein glycosylation in Trypanosoma cruzi. II. Partial characterization of protein-bound oligosaccharides labeled "in vivo".

1982 • 51 citations

Calnexin Associates Exclusively with Individual CD3δ and T Cell Antigen Receptor (TCR) α Proteins Containing Incompletely Trimmed Glycans That Are Not Assembled into Multisubunit TCR Complexes

1996 • 51 citations

Phylogenetic survey of endomannosidase indicates late evolutionary appearance of this N-linked oligosaccharide processing enzyme

1997 • 51 citations

A mutation that prevents glucosylation of the lipid-linked oligosaccharide precursor leads to underglycosylation of secreted yeast invertase.

1986 • 51 citations

Characterization of dolichol diphosphate oligosaccharide: protein oligosaccharyltransferase and glycoprotein-processing glucosidases occurring in trypanosomatid protozoa.

1988 • 48 citations

Degradation of Human Thyroperoxidase in the Endoplasmic Reticulum Involves Two Different Pathways Depending on the Folding State of the Protein

2000 • 48 citations

Glucosidase I, a transmembrane endoplasmic reticular glycoprotein with a luminal catalytic domain.

1991 • 47 citations

The UDP-Glc:glycoprotein glucosyltrasferase is a soluble protein of the endoplasmic reticulum

1991 • 47 citations

Uridine Diphosphate–Glucose Transport into the Endoplasmic Reticulum ofSaccharomyces cerevisiae:In Vivo and In Vitro Evidence

1999 • 46 citations

A misfolded protein conformation is not a sufficient condition for invivo glucosylation by the UDP-Glc:glycoprotein glucosyltransferase

1998 • 45 citations

The gene for a novel protein, a member of the protein disulphide isomerase/form I phosphoinositide-specific phospholipase C family, is amplified in hydroxyurea-resistant cells

1992 • 39 citations

Mannose Trimming Targets Mutant α2-Plasmin Inhibitor for Degradation by the Proteasome

2000 • 33 citations

Mutation of Arg273 to Leu Alters the Specificity of the Yeast N-Glycan Processing Class I α1,2-Mannosidase

2000 • 32 citations

Studies on Degradative Mechanisms Mediating Post-translational Fragmentation of Apolipoprotein B and the Generation of the 70-kDa Fragment

1999 • 32 citations

Calnexin Interaction with N-Glycosylation Mutants of a Polytopic Membrane Glycoprotein, the Human Erythrocyte Anion Exchanger 1 (Band 3)

1999 • 31 citations

Inhibition of invariant chain (Ii)-calnexin interaction results in enhanced degradation of Ii but does not prevent the assembly of alpha beta Ii complexes.

1995 • 30 citations

Differential role of mannose and glucose trimming in the ER degradation of asialoglycoprotein receptor subunits

1999 • 27 citations

Truncated N-glycans affect protein folding in the ER of CHO-derived mutant cell lines without preventing calnexin binding

2000 • 27 citations

Molecular Cloning and Characterization of a cDNA for Bovine Phospholipase C-α: Proposal of Redesignation of Phospholipase C-α

1994 • 25 citations

Calnexin Association Is Not Sufficient to Protect T Cell Receptor α Proteins from Rapid Degradation in CD4+CD8+ Thymocytes

1998 • 16 citations

Plasmodesmata: Gateways for rapid information transfer

1994 • 16 citations

Tetrahymena pyriformis cells are deficient in all mannose-P-dolichol-dependent mannosyltransferases but not in mannose-P-dolichol synthesis

1987 • 9 citations

The interaction of the UDP-GLC:glycoprotein glucosyltransferase with the acceptor glycoprotein.

1996 • 6 citations