Studies on Degradative Mechanisms Mediating Post-translational Fragmentation of Apolipoprotein B and the Generation of the 70-kDa Fragment

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Fluorescein isothiocyanate-labeled casein assay for proteolytic enzymes

1984 • 555 citations

The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life.

1989 • 414 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin

1996 • 370 citations

The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70

1997 • 285 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin in Cultured Cells

1997 • 231 citations

Inhibitory Effect of di- and Tripeptidyl Aldehydes on Calpains and Cathepsins

1990 • 204 citations

Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. Evidence for two functionally distinct pools.

1990 • 192 citations

Ubiquitin-Proteasome Pathway Mediates Intracellular Degradation of Apolipoprotein B

1996 • 187 citations

Studies on the assembly of apo B-100-containing lipoproteins in HepG2 cells.

1988 • 186 citations

The assembly and secretion of ApoB 100-containing lipoproteins in Hep G2 cells. ApoB 100 is cotranslationally integrated into lipoproteins.

1992 • 170 citations

Regulated Co-translational Ubiquitination of Apolipoprotein B100

1998 • 154 citations

Oleic acid stimulation of apolipoprotein B secretion from HepG2 and Caco-2 cells occurs post-transcriptionally

1990 • 151 citations

Effects of oleate and insulin on the production rates and cellular mRNA concentrations of apolipoproteins in HepG2 cells.

1989 • 150 citations

Co-translational Degradation of Apolipoprotein B100 by the Proteasome Is Prevented by Microsomal Triglyceride Transfer Protein

1997 • 142 citations

Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells.

1993 • 134 citations

Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells.

1992 • 131 citations

Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence

1998 • 120 citations

Regulated intracellular degradation of apolipoprotein B in semipermeable HepG2 cells.

1994 • 108 citations

Impaired biosynthesis of phosphatidylcholine causes a decrease in the number of very low density lipoprotein particles in the Golgi but not in the endoplasmic reticulum of rat liver.

1993 • 106 citations

Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line.

1992 • 97 citations

Proteasome-mediated Degradation of Apolipoprotein B Targets Both Nascent Peptides Cotranslationally Before Translocation and Full-length Apolipoprotein B After Translocation into the Endoplasmic Reticulum

1998 • 97 citations

Calnexin and Other Factors That Alter Translocation Affect the Rapid Binding of Ubiquitin to ApoB in the Sec61 Complex

1998 • 94 citations

A Two-site Model for ApoB Degradation in HepG2 Cells

1997 • 89 citations

Proteolysis-coupled secretion of the N terminus of apolipoprotein B. Characterization of a transient, translocation arrested intermediate.

1994 • 88 citations

In HepG2 Cells, Translocation, Not Degradation, Determines the Fate of the de Novo Synthesized Apolipoprotein B

1995 • 83 citations

Synthesis and secretion of apolipoprotein B from cultured liver cells

1995 • 82 citations

Intrahepatic assembly of very low density lipoproteins: immunologic characterization of apolipoprotein B in lipoproteins and hepatic membrane fractions and its intracellular distribution.

1989 • 77 citations

Degradation of Apolipoprotein B in Cultured Rat Hepatocytes Occurs in a Post-endoplasmic Reticulum Compartment

1995 • 66 citations

Apolipoprotein B Is Intracellularly Associated with an ER-60 Protease Homologue in HepG2 Cells

1997 • 64 citations

Role of intramolecular disulfide bond formation in the assembly and secretion of apolipoprotein B-100-containing lipoproteins

1996 • 62 citations

Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine.

1993 • 60 citations

Specificities of Cell Permeant Peptidyl Inhibitors for the Proteinase Activities of μ-Calpain and the 20 S Proteasome

1997 • 59 citations

Transit and sorting of apolipoprotein B within the endoplasmic reticulum and Golgi compartments of isolated hepatocytes from normal and orotic acid-fed rats.

1993 • 55 citations

Secretion of apolipoprotein B in serum‐free cultures of human hepatoma cell line, HepG2

1990 • 46 citations

Hormonal regulation of lipoprotein assembly and secretion

1993 • 44 citations

Intracellular Assembly and Degradation of Apolipoprotein B-100-containing Lipoproteins in Digitonin-permeabilized HEP G2 Cells

1997 • 37 citations

Inhibition of Secretion of Truncated Apolipoproteins B by Monomethylethanolamine Is Independent of the Length of the Apolipoprotein

1995 • 32 citations

Intracellular Translocation and Stability of Apolipoprotein B Are Inversely Proportional to the Length of the Nascent Polypeptide

1998 • 31 citations

Intracellular degradation of apolipoprotein B generates an N-terminal 70 kDa fragment in the endoplasmic reticulum

1995 • 24 citations

Conformational Changes in Apolipoprotein B Modulate Intracellular Assembly and Degradation of ApoB-Containing Lipoprotein Particles in HepG2 Cells

1997 • 22 citations

Stimulation of thymidylate kinase and deoxycytidylate deaminase activities of chang cells by deoxyadenosine

1969 • 12 citations