Calnexin: a molecular chaperone with a taste for carbohydrate

Protein folding in the cell

1992 • 4,138 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control.

1994 • 815 citations

Biology of Animal Lectins

1993 • 752 citations

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

1994 • 651 citations

Association of folding intermediates of glycoproteins with calnexin during protein maturation

1993 • 558 citations

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

1994 • 430 citations

Antibodies to the Golgi complex and the rough endoplasmic reticulum.

1982 • 418 citations

Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator.

1994 • 359 citations

Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90)

1994 • 351 citations

Folding of VSV G Protein: Sequential Interaction with BiP and Calnexin

1994 • 316 citations

Participation of a novel 88-kD protein in the biogenesis of murine class I histocompatibility molecules.

1991 • 312 citations

The endoplasmic reticulum as a protein-folding compartment

1992 • 296 citations

Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

1992 • 259 citations

Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin)

1993 • 203 citations

Calnexin and BiP act as sequential molecular chaperones during thyroglobulin folding in the endoplasmic reticulum.

1995 • 194 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

A role for calnexin (IP90) in the assembly of class II MHC molecules.

1994 • 144 citations

Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

1994 • 124 citations

Persistence of glucose residues on core oligosaccharides prevents association of TCR alpha and TCR beta proteins with calnexin and results specifically in accelerated degradation of nascent TCR alpha proteins within the endoplasmic reticulum.

1994 • 117 citations

Association between calnexin and a secretion-incompetent variant of human alpha 1-antitrypsin.

1994 • 112 citations

The p88 molecular chaperone is identical to the endoplasmic reticulum membrane protein, calnexin.

1992 • 110 citations

Role of .beta.2-microglobulin in the intracellular processing of HLA antigens

1981 • 109 citations

Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum.

1994 • 106 citations

Primary structure and characterization of an Arabidopsis thaliana calnexin-like protein.

1993 • 104 citations

Primary structure of human thromboxane synthase determined from the cDNA sequence.

1992 • 99 citations

The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly.

1994 • 97 citations

Intracellular protein trafficking defects in human disease

1992 • 96 citations

Identification of the region on the class I histocompatibility molecule that interacts with the molecular chaperone, p88 (calnexin, IP90).

1993 • 77 citations

The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene.

1992 • 74 citations

The Schizosaccharomyces pombe Homologue of the Chaperone Calnexin Is Essential for Viability

1995 • 72 citations

The formation of vesicular stomatitis virus (San Juan strain) becomes temperature-sensitive when glucose residues are retained on the oligosaccharides of the glycoprotein.

1984 • 72 citations

Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum

1994 • 59 citations

Characterization of BcgI, a new kind of restriction-modification system.

1994 • 59 citations

Purification of a 90-kDa protein (Band VII) from cardiac sarcoplasmic reticulum. Identification as calnexin and localization of casein kinase II phosphorylation sites.

1993 • 50 citations

Molecular cloning and expression of SmIrV1, a Schistosoma mansoni antigen with similarity to calnexin, calreticulin, and OvRal1.

1993 • 38 citations

CNE1, a Saccharomyces cerevisiae Homologue of the Genes Encoding Mammalian Calnexin and Calreticulin

1993 • 33 citations