Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

What is synergy?

1989 • 1,315 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Mechanism of multidrug resistance

1988 • 630 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

1990 • 386 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

The Two Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Have Distinct Functions in Controlling Channel Activity

1995 • 273 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

1993 • 220 citations

Multidrug resistance (mdr) genes in human cancer

1991 • 209 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

1992 • 190 citations

The effects of lipids and detergents on ATPase-active P-glycoprotein

1993 • 186 citations

Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells.

1991 • 178 citations

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

1988 • 176 citations

Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides.

1994 • 174 citations

Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells.

1990 • 167 citations

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

1992 • 157 citations

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1992 • 147 citations

How does a calcium pump pump calcium?

1989 • 147 citations

Flip-flop: The transmembrane translocation of lipids

1994 • 144 citations

ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.

1988 • 143 citations

Covalent inhibitors of P-glycoprotein ATPase activity.

1994 • 139 citations

Competitive inhibition by verapamil of ATP-dependent high affinity vincristine binding to the plasma membrane of multidrug-resistant K562 cells without calcium ion involvement.

1989 • 138 citations

Cortisol is transported by the multidrug resistance gene product P-glycoprotein

1993 • 138 citations

Effects of Lipids on ATPase Activity of Purified Chinese Hamster P-Glycoprotein

1995 • 117 citations

Antiestrogens and steroid hormones: Substrates of the human P-glycoprotein

1994 • 115 citations

Differential transport properties of two mdr gene products are distinguished by progesterone.

1990 • 103 citations

P‐glycoprotein transports corticosterone and is photoaffinity‐labeled by the steroid

1992 • 92 citations

Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles

1991 • 85 citations

Progesterone photoaffinity labels P-glycoprotein in multidrug-resistant human leukemic lymphoblasts.

1990 • 80 citations

Steroid hormones inhibit binding of alkaloid to multidrug resistance related P-glycoprotein

1989 • 74 citations

Reversal of multidrug resistance by lipophilic drugs.

1990 • 73 citations

Mutation of Glycine 185 to Valine Alters the ATPase Function of the Human P-glycoprotein Expressed in Sf9 Cells

1995 • 62 citations

Megestrol acetate reverses multidrug resistance and interacts with P-glycoprotein

1992 • 61 citations

Discrete Mutations Introduced in the Predicted Nucleotide-Binding Sites of the mdr1 Gene Abolish Its Ability To Confer Multidrug Resistance

1989 • 57 citations

Absence of Cooperativity for MgATP and Verapamil Effects on the ATPase Activity of P-Glycoprotein Containing Membrane Vesicles

1993 • 47 citations

Effect of diethylstilbestrol and related compounds on the Ca(2+)-transporting ATPase of sarcoplasmic reticulum.

1992 • 41 citations

Non-competitive inhibition of P-glycoprotein-associated efflux of THP-adrimycin by verapamil in living K562 leukemia cells

1994 • 40 citations

Progesterone and its metabolites: the potent inhibitors of the transporting activity of P-glycoprotein in the adrenal gland

1993 • 32 citations

How Do Volatile Anesthetics Inhibit Ca2+-ATPases?

1995 • 31 citations

Thermodynamics of steroid partitioning in dimyristoylphosphatidylcholine liposomes

1983 • 27 citations