Development of a flexible and specific gene delivery system for production of murine tumor models

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

Integration of murine leukemia virus DNA depends on mitosis.

1993 • 931 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

A transient three-plasmid expression system for the production of high titer retroviral vectors

1995 • 686 citations

Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

1987 • 651 citations

A constitutively active epidermal growth factor receptor cooperates with disruption of G₁ cell-cycle arrest pathways to induce glioma-like lesions in mice

1998 • 560 citations

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

1994 • 439 citations

TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor

1992 • 409 citations

A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor

1993 • 351 citations

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

1998 • 306 citations

Transcriptional Elements from the Human SP-C Gene Direct Expression in the Primordial Respiratory Epithelium of Transgenic Mice

1993 • 299 citations

Transgenic Models of Tumor Development

1991 • 289 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses

1993 • 203 citations

The EV-O-Derived Cell Line DF-1 Supports the Efficient Replication of Avian Leukosis-Sarcoma Viruses and Vectors

1998 • 191 citations

Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse.

1992 • 166 citations

Replication-competent retrovirus vectors for the transfer and expression of gene cassettes in avian cells

1991 • 163 citations

A system for tissue-specific gene targeting: transgenic mice susceptible to subgroup A avian leukosis virus-based retroviral vectors.

1994 • 141 citations

Insights into cancer from transgenic mouse models

1999 • 138 citations

Modeling mutations in the G₁ arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a–ARF induces hyperploidy in cultured mouse astrocytes

1998 • 124 citations

Cis-acting sequences from a human surfactant protein gene confer pulmonary-specific gene expression in transgenic mice.

1990 • 110 citations

Mouse papillary lung tumors transplacentally induced by N-nitrosoethylurea: Evidence for alveolar type II cell origin by comparative light microscopic, ultrastructural, and immunohistochemical studies

1989 • 84 citations

Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occurring pulmonary neoplasms of mice

1985 • 80 citations

Multiple molecular alterations in mouse lung tumors

1992 • 59 citations

Transgenic models for study of pulmonary development and disease

1994 • 47 citations

A New Defective Retroviral Vector System Based on the Bryan Strain of Rous Sarcoma Virus

1993 • 45 citations

Helper-independent retrovirus vectors with Rous-associated virus type O long terminal repeats

1988 • 44 citations

Expression of transduced genes in mice generated by infecting blastocysts with avian leukosis virus-based retroviral vectors.

1996 • 39 citations

A model for studying megakaryocyte development and biology

1999 • 32 citations

MHC and Non-MHC Genes in Lung Tumor Susceptibility in the Mouse: Implications for the Study of the Different Lung Tumor Types and Their Cell of Origin

1991 • 26 citations

Immunologic tolerance

1997 • 17 citations

Variable expression of human transgenes in SHN mice

1996 • 3 citations