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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

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Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Soluble receptors for cytokines and growth factors: generation and biological function

1994 • 766 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

CNTF Protection of Oligodendrocytes Against Natural and Tumor Necrosis Factor-Induced Death

1993 • 486 citations

Neuropoietic cytokines in the hematopoietic fold

1991 • 474 citations

A protein complex required for signal-sequence-specific sorting and translocation

1994 • 404 citations

The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development

1993 • 402 citations

Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses

1993 • 350 citations

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

1988 • 343 citations

Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro

1994 • 285 citations

Injury‐induced Regulation of Ciliary Neurotrophic Factor mRNA in the Adult Rat Brain

1993 • 251 citations

Ciliary neurotrophic factor

1994 • 246 citations

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1988 • 182 citations

Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas.

1995 • 178 citations

Astroglial neurotrophic and neurite-promoting factors

1995 • 170 citations

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1995 • 168 citations

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1994 • 164 citations

Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing.

1995 • 146 citations

Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system.

1996 • 140 citations

The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?

1992 • 135 citations

Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells.

1988 • 130 citations

Ciliary neurotrophic factor and its receptor complex

1992 • 128 citations

Regulation of an oligodendrocyte progenitor cell line by the interleukin‐6 family of cytokines

1994 • 127 citations

Acute Exposure to CNTFin VivoInduces Multiple Components of Reactive Gliosis

1996 • 114 citations

CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system

1995 • 110 citations

Ciliary neurotrophic factor: A review

1994 • 105 citations

Cytokines and tumors of the central nervous system

1995 • 100 citations

Increased CNTF gene expression in process‐bearing astrocytes following injury is augmented by R(−)‐deprenyl

1994 • 93 citations

Secretion of Peptides and Proteins Lacking Hydrophobic Signal Sequences: The Role of Adenosine Triphosphate-Driven Membrane Translocators*

1992 • 92 citations

Complementation by Wild-Type p53 of Interleukin-6 Effects on M1 Cells: Induction of Cell Cycle Exit and Cooperativity with c-myc Suppression

1993 • 91 citations

Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer. Malignant melanoma as a paradigm.

1992 • 89 citations

Oligodendroblasts Distinguished from O-2A Glial Progenitors by Surface Phenotype (O4+GalC-) and Response to Cytokines Using Signal Transducer LIFRβ

1995 • 78 citations

High and low affinity receptors for human interleukin for DA cells/leukemia inhibitory factor on human cells. Molecular characterization and cellular distribution.

1992 • 77 citations

Characteristic Localization of gpl30 (the Signal‐transducing Receptor Component Used in Common for IL‐6/IL‐11/CNTF/LIF/OSM) in the Rat Brain

1996 • 67 citations

Is IL-6 both a cytokine and a neurotrophic factor?

1996 • 64 citations

Release of ciliary neurotrophic factor from cultured astrocytes and its modulation by cytokines

1995 • 59 citations

Localization of CNTF immunoreactivity to neurons and astroglia in the CNS

1994 • 55 citations

Cytokines affecting survival and differentiation of an astrocyte progenitor cell line

1993 • 52 citations

Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.

1994 • 51 citations

The epidermal growth factor receptor in glioblastoma: genomic amplification, protein expression, and patient survival data in a therapeutic trial.

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Membrane translocation of proteins without hydrophobic signal peptides

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Inhibition of Growth and Induction of Differentiation of Glioma Cell Lines by Oncostatin M (OSM)

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Expression of ciliary neurotrophic factor receptor mRNA and protein in the early postnatal and adult rat nervous system

1994 • 41 citations

The evidence for interleukin-6 as an autocrine growth factor in malignancy.

1992 • 40 citations

Increased Expression of CNTF Receptor α in Denervated Human Skeletal Muscle

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Growth inhibition of newly established human glioma cell lines by leukemia inhibitory factor.

1998 • 37 citations

CNTF induces GFAP in a S-100α brain cell population: the pattern of CNTF-αR suggests an indirect mode of action

1997 • 35 citations

CNTF receptor α mRNA expression in rodent cell lines and developing rat

1994 • 27 citations

Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer. Malignant melanoma as a paradigm.

1992 • 26 citations

Site‐directed mutagenesis of human CNTF: Functional analysis of recombinant variants

1995 • 12 citations