A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

1988 • 745 citations

THE PROTEIN KINASE C FAMILY: HETEROGENEITY AND ITS IMPLICATIONS

1989 • 739 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

The Alu Family of Dispersed Repetitive Sequences

1982 • 611 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

Cloning of the $beta; subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family

1987 • 520 citations

Structure of tumour necrosis factor

1989 • 512 citations

A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity

1989 • 442 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

cDNA sequences of two inducible T-cell genes.

1989 • 392 citations

Two Different Cell Types have Different Major Receptors for Human Tumor Necrosis Factor (TNFα)

1989 • 368 citations

Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor.

1986 • 293 citations

Uromodulin (Tamm-Horsfall Glycoprotein): a Renal Ligand for Lymphokines

1987 • 278 citations

Cloning the interleukin 1 receptor from human T cells.

1989 • 267 citations

Isolation and characterization of a tumor necrosis factor binding protein from urine

1989 • 249 citations

Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells

1986 • 219 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae.

1986 • 175 citations

Heterogeneity in Human Interleukin-3 Receptors

1989 • 153 citations

The lectin-like interaction between recombinant tumor necrosis factor and uromodulin.

1988 • 123 citations

The role of tumor necrosis factor (cachectin) in cachexia

1988 • 117 citations

The interaction of monoclonal antibodies with MHC class I antigens on mouse spleen cells. I. Analysis of the mechanism of binding.

1984 • 115 citations

Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes.

1988 • 107 citations

Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand.

1987 • 102 citations

Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.

1988 • 101 citations

Tumorigenic poxviruses: Genomic organization and dna sequence of the telomeric region of the shope fibroma virus genome

1987 • 75 citations

Tumor necrosis factor: receptors on hematopoietic cells

1987 • 68 citations

The effects of human recombinant tumor necrosis factor on glioma‐derived cell lines: Cellular proliferation, cytotoxicity, morphological and radioreceptor studies

1988 • 56 citations

Characterization of specific high affinity receptors for human tumor necrosis factor on mouse fibroblasts.

1985 • 49 citations

Regulation of B cell maturation and differentiation. I. Suppression of pokeweed mitogen-induced B cell differentiation by tumor necrosis factor (TNF).

1987 • 49 citations

Characterization and Affinity Cross-linking of Receptors for Human Recombinant Lymphotoxin (Tumor Necrosis Factor-β) on a Human Histiocytic Lymphoma Cell Line, U-937

1989 • 48 citations

Tumor necrosis factor: receptors on hematopoietic cells

1987 • 30 citations

Differential biologic effects resulting from bimodal binding of recombinant human tumor necrosis factor to myeloid leukemia cells

1989 • 25 citations