Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

1981 • 1,881 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational system

1981 • 1,405 citations

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

1977 • 1,252 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Transfer of Proteins Across Membranes

1981 • 894 citations

Synthesis of deoxyoligonucleotides on a polymer support

1981 • 870 citations

Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes

1982 • 850 citations

Expression of human immune interferon cDNA in E. coli and monkey cells

1982 • 703 citations

Efficient transcription of RNA into DNA by avian sarcoma virus polymerase

1976 • 688 citations

Human leukocyte interferon produced by E. coli is biologically active

1980 • 528 citations

Pretreatment of plastic petri dishes with fetal calf serum. A simple method for macrophage isolation

1979 • 498 citations

Molecular cloning of cDNA for murine interleukin-3

1984 • 485 citations

Inhibition of intractable, nucleases with ribonucleoside-vanadyl complexes: isolation of messenger ribonucleic acid from resting lymphocytes

1979 • 461 citations

Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon.

1983 • 458 citations

Cloning and expression of murine immune interferon cDNA.

1983 • 455 citations

Hormonal Proteins and Peptides

1979 • 428 citations

Macrophages as a source of tumoricidal activity (tumor-necrotizing factor)

1980 • 398 citations

Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I.

1978 • 395 citations

CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY

1968 • 298 citations

[58] DNA sequence analysis by primed synthesis

1980 • 286 citations

Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization.

1984 • 284 citations

Lymphocyte in vitro cytotoxicity: mechanisms of immune and nonimmune small lymphocyte mediated target L cell destruction

1968 • 230 citations

Ylmphocyte in Vitro Cytotoxicity: Mechanisms of Immune and Non-Immune Small Lymphocyte Mediated Target L Cell Destruction

1968 • 191 citations

Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin.

1984 • 187 citations

Thymic Hormones and Lymphokines

1984 • 182 citations

Partial purification of a serum factor that causes necrosis of tumors.

1976 • 146 citations

Selective lysis of NK-sensitive target cells by a soluble mediator released from murine spleen cells and human peripheral blood lymphocytes.

1981 • 141 citations

Cell-Mediated Immunity in Vitro: A Highly Sensitive Assay for Human Lymphotoxin

1974 • 110 citations

Preliminary characterization of the tumor cell cytotoxin in tumor necrosis serum.

1981 • 94 citations

Stimulation of RNA Synthesis in L-929 Cells by Rabbit Tumor Necrosis Factor

1979 • 81 citations

Identification of human natural killer soluble cytotoxic factors (NKCF) derived from NK-enriched lymphocyte populations: specificity of generation and killing.

1983 • 80 citations

The human LT system

1978 • 78 citations

Cytotoxic activity of lymphocytes. VI. Heterogeneity of cytotoxins in supernatants of mitogen-activated lymphocytes.

1976 • 66 citations

In vitro synergism between interferons and human lymphotoxin: enhancement of lymphotoxin-induced target cell killing.

1983 • 64 citations

Characterization of intact and trypsin-digested biosynthetic human growth hormone by high-pressure liquid chromatography

1982 • 63 citations

Preferential codon usage in genes

1981 • 62 citations

Cytotoxic Activity of Lymphocytes

1976 • 45 citations

The LT system in experimental animals. III. Physicochemical characteristics and relationships of lymphotoxin (LT) molecules released in vitro by activated lymphoid cells from several animal species.

1979 • 30 citations

Separation and purification of the mRNAs for vesciular stomatitis virus NS and M proteins

1979 • 27 citations

Lymphotoxin, a biologically relevant model lymphokine.

1983 • 24 citations

Species specificity of guinea pig and human lymphotoxin colony inhibitory activity

1981 • 21 citations

Chemical and Biological Properties of Human Lymphotoxin

1984 • 20 citations

The Chemistry of Glycoproteins

1973 • 18 citations

Lymphokine-mediated immunotherapy studies in mouse tumor systems

1980 • 18 citations

The LT System in Experimental Animals

1979 • 16 citations

Regression of Malignant Melanoma in a Dog by Local Injections of a Partially Purified Preparation Containing Human -Lymphotoxin

1982 • 13 citations

Lymphotoxins: a multicomponent system of cell-lytic lymphocyte-released effector molecules.

1982 • 11 citations