Production of lymphotoxin (LTα) and a soluble dimeric form of its receptor using the baculovirus expression system

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

1938 • 19,183 citations

A simple method of estimating 50 per cent end points

1938 • 8,381 citations

Baculovirus expression vectors: a laboratory manual.

1992 • 1,799 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Surface-specific iodination of membrane proteins of viruses and eucaryotic cells using 1,3,4,6-tetrachloro-3α,6α-diphenylglycoluril

1978 • 912 citations

Production of human beta interferon in insect cells infected with a baculovirus expression vector.

1983 • 907 citations

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

1992 • 832 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

1984 • 638 citations

Tumor necrosis factor.

1991 • 568 citations

Rapid colormetric assay for cell viability: Application to the quantitation of cytotoxic and growth inhibitory lymphokines

1984 • 561 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Baculovirus expression vectors: A laboratory manual

1993 • 478 citations

Production of human α-interferon in silkworm using a baculovirus vector

1985 • 475 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

1990 • 396 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

Modification and secretion of human interleukin 2 produced in insect cells by a baculovirus expression vector.

1985 • 286 citations

Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor

1993 • 280 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality

1991 • 239 citations

Characterization in vitro of a human tumor necrosis factor-binding protein. A soluble form of a tumor necrosis factor receptor.

1990 • 227 citations

The Common Mediator of Shock, Cachexia, and Tumor Necrosis

1988 • 175 citations

Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type I TNF receptor during activation of resting and effector T cells.

1991 • 174 citations

Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.

1990 • 141 citations

Tumor necrosis factor α in autoimmunity: pretty girl or old witch?

1992 • 128 citations

Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines.

1989 • 78 citations

Active human erythropoietin expressed in insect cells using a baculovirus vector: A role for N-linked oligosaccharide

1987 • 61 citations

Tumor Necrosis Factor Structure, Mechanism of Action, Role in Disease and Therapy

1991 • 57 citations

Soluble tumor necrosis factor receptor: inhibition of human immunodeficiency virus activation.

1993 • 54 citations

Biochemical characterization of the extracellular domain of the 75-kilodalton tumor necrosis factor receptor

1993 • 46 citations

Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma.

1990 • 44 citations

Production and purification of recombinant human interleukin‐5 from yeast and baculovirus expression systems

1991 • 30 citations

Expression of human granulocyte‐macrophage colony‐stimulating factor gene in insect cells by a baculovirus vector

1990 • 24 citations

The relationship of receptor occupancy to the kinetics of cell death mediated by tumor necrosis factor.

1988 • 17 citations

Human T cell hybridomas producing cytotoxic lymphokines: induction of lymphotoxin release and killer cell activity by anti-CD3 monoclonal antibody or lectins and phorbol ester.

1986 • 9 citations

Biological function of recombinant IL-6 expressed in a baculovirus system.

1991 • 6 citations

Differences in the Biological Responses and the Structure of Lymphotoxin and Tumor Necrosis Factor

2015 • 3 citations

Deleted Work

1955 • 0 citations