Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking.

1991 • 552 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum

1989 • 499 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells.

1991 • 390 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Gene organization and recombinational hotspots in the murine major histocompatibility complex

1986 • 312 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains

1982 • 183 citations

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1994 • 175 citations

Irreversible association of peptides with class II MHC molecules in living cells

1992 • 173 citations

Empty and peptide-containing conformers of class I major histocompatibility complex molecules expressed in Drosophila melanogaster cells.

1992 • 143 citations

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

1994 • 135 citations

New class ll-like genes in the murine MHC

1991 • 129 citations

A novel class II MHC molecule with unusual tissue distribution

1991 • 126 citations

Biosynthesis and maturation of HLA-DR antigens in vivo.

1981 • 111 citations

Structural Intermediates in the Reactions of Antigenic Peptides with MHC Molecules

1989 • 107 citations

Identification of two distinct properties of class II major histocompatibility complex-associated peptides.

1993 • 101 citations

Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structures.

1994 • 96 citations

Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines.

1994 • 77 citations

A monoclonal antibody detecting an Ia specificity mapping in the I-A or I-E subregion

1981 • 70 citations

Characterization of HLA-DMB polymorphism

1993 • 59 citations

Intracellular distribution of the MHC class II molecules and the associated invariant chain (li) in different cell lines

1993 • 58 citations

Limited polymorphism in HLA-DM does not involve the peptide binding groove

1994 • 54 citations

A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.

1991 • 42 citations