Effects of Ion Radiation on Cells and Tissues

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Zur Theorie des Durchgangs schneller Korpuskularstrahlen durch Materie

1930 • 3,860 citations

DNA double-strand breaks: signaling, repair and the cancer connection

2001 • 2,372 citations

ACTION OF X-RAYS ON MAMMALIAN CELLS

1956 • 1,660 citations

Radiological Use of Fast Protons

1946 • 1,301 citations

Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy

1999 • 842 citations

Magnetic scanning system for heavy ion therapy

1993 • 707 citations

The Complexity of DNA Damage: Relevance to Biological Consequences

1994 • 604 citations

Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells

2001 • 586 citations

The 200‐MeV proton therapy project at the Paul Scherrer Institute: Conceptual design and practical realization

1995 • 575 citations

Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to Very Low Fluences of Alpha Particles

1998 • 509 citations

Induction of a bystander mutagenic effect of alpha particles in mammalian cells

2000 • 473 citations

Treatment volume and tissue tolerance

1988 • 441 citations

Computation of cell survival in heavy ion beams for therapy

1997 • 434 citations

Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose

2000 • 424 citations

Inactivation of Aerobic and Hypoxic Cells from Three Different Cell Lines by Accelerated³He-,¹²C- and²⁰Ne-Ion Beams

2000 • 424 citations

Tumor therapy with heavy charged particles

2000 • 415 citations

Studies of bystander effects in human fibroblasts using a charged particle microbeam

1998 • 410 citations

Cellular basis of radiation-induced fibrosis

1995 • 371 citations

Theory of RBE for Heavy Ion Bombardment of Dry Enzymes and Viruses

1967 • 367 citations

A Generalized Formulation of Dual Radiation Action

1978 • 367 citations

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1983 • 345 citations

The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells

1991 • 330 citations

Inactivation of Cells by Heavy Ion Bombardment

1971 • 323 citations

The Role of DNA Single- and Double-Strand Breaks in Cell Killing by Ionizing Radiation

1998 • 322 citations

The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10T½ CellsIn Vitrocan be Initiated in the Unirradiated Neighbors of Irradiated Cells

2001 • 308 citations

Microdosimetry and Its Applications

1996 • 294 citations

RBE for carbon track-segment irradiation in cell lines of differing repair capacity

1999 • 292 citations

Track structure in radiation biology: theory and applications

1998 • 286 citations

Advances in Radiation Biology

1975 • 283 citations

Evidence for DNA Double-Strand Breaks as the Critical Lesions in Yeast Cells Irradiated with Sparsely or Densely Ionizing Radiation under Oxic or Anoxic Conditions

1981 • 271 citations

Cell Cycle Control

1995 • 259 citations

Effects of Different Ionizing Radiations on Human Cells in Tissue Culture: II. Biological Experiments

1960 • 256 citations

Track structure and the calculation of biological effects of heavy charged particles

1996 • 254 citations

Extracellular Signaling through the Microenvironment: A Hypothesis Relating Carcinogenesis, Bystander Effects, and Genomic Instability

2001 • 252 citations

The Effect of Oxygen on Impairment of the Proliferative Capacity of Human Cells in Culture by Ionizing Radiations of Different LET

1966 • 250 citations

A review of dsb induction data for varying quality radiations

1998 • 228 citations

Tumor biology and experimental therapeutics

2000 • 218 citations

Inactivation of Human Kidney Cells by High-Energy Monoenergetic Heavy-Ion Beams

1979 • 214 citations

Effects of Different Ionizing Radiations on Human Cells in Tissue Culture: III. Experiments with Cyclotron-Accelerated Alpha-Particles and Deuterons

1963 • 211 citations

Compartmentalization of Interphase Chromosomes Observed in Simulation and Experiment

1999 • 207 citations

The cellular internet: On‐line with connexins

1996 • 201 citations

The Columbia University Single-Ion Microbeam

2001 • 199 citations

How Do Tissues Respond to Damage at the Cellular Level? The Role of Cytokines in Irradiated Tissues

1998 • 191 citations

The Relative Radiosensitivity of the Nucleus and Cytoplasm of Chinese Hamster Fibroblasts

1970 • 183 citations

A charged-particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles

1997 • 181 citations

Studies on mammalian mutants defective in rejoining double-strand breaks in DNA

1990 • 178 citations

Molecular and Biochemical Characterization of xrs Mutants Defective in Ku80

1997 • 174 citations

A model of ion track structure based on classical collision dynamics (radiobiology application)

1986 • 164 citations

Review: Proximity effects in the production of chromosome aberrations by ionizing radiation

1997 • 156 citations

Adaptive Response and the Bystander Effect Induced by Radiation in C3H 10T½ Cells in Culture

2001 • 146 citations

Proton Beams in Radiation Therapy

1992 • 141 citations

Calculations of heavy-ion track structure

1994 • 141 citations

Bacq and Alexander Award Lecture Chemical radioprotection: past, present and future prospects

1998 • 136 citations

Sensitivity of CHO mutant cell lines with specific defects in nucleotide excision repair to different anti-cancer agents

1996 • 131 citations

Nuclear architecture and the induction of chromosomal aberrations

1996 • 131 citations

Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility

1993 • 120 citations

A charged-particle microbeam: II. A single-particle micro-collimation and detection system.

1997 • 120 citations

Results of heavy ion radiotherapy

1995 • 120 citations

Measurements of Relative Biological Effectiveness of the 70 MeV Proton Beam at TRIUMF Using Chinese Hamster V79 Cells and the High-Precision Cell Sorter Assay

1996 • 119 citations

Rejoining and Misrejoining of Radiation-Induced Chromatin Breaks. IV. Charged Particles

1998 • 105 citations

DNA Double-strand Breaks: Their Repair and Relationship to Cell Killing in Yeast

1990 • 104 citations

Direct Comparison between Protons and Alpha-particles of the Same LET: I. Irradiation Methods and Inactivation of Asynchronous V79, HeLa and C3H 10T½ Cells

1992 • 104 citations

Multicellular tumour spheroids in radiation biology

1999 • 100 citations

Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells

1996 • 98 citations

Detecting, signalling and repairing DNA double-strand breaks

2001 • 96 citations

Molecular and cellular radiobiology of heavy ions

1982 • 92 citations

Invited review Multicell spheroids as a model for cell kinetic studies

1990 • 90 citations

Inactivation and Mutation of Cultured Mammalian Cells by Aluminium Characteristic Ultrasoft X-rays

1977 • 89 citations

The radiobiological and physical basis for radiotherapy with protons and heavier ions.

1990 • 87 citations

Detecting, signalling and repairing DNA double-strand breaks

2001 • 87 citations

Low-Dose Hypersensitivity in Chinese Hamster V79 Cells Targeted with Counted Protons Using a Charged-Particle Microbeam

2001 • 85 citations

Lethality of Heavy Ion-induced DNA Double-strand Breaks in Mammalian Cells

1993 • 84 citations

Polymer models for interphase chromosomes.

1993 • 80 citations

Bestrahlung von Schädelbasistumoren mit Kohlenstoffionen bei der GSI Erste klinische Ergebnisse und zukünftige Perspektiven

2000 • 80 citations

DNA Strand Break Induction and Rejoining and Cellular Recovery in Mammalian Cells after Heavy-Ion Irradiation

1993 • 74 citations

Radiobiological Effectiveness of Radiation Beams with Broad LET Spectra: Microdosimetric Analysis Using Biological Weighting Functions

1994 • 73 citations

Comparison of chromosomal damage induced by X-rays and Ar ions with an LET of 1840 keV/ mum in G1 V79 cells

1996 • 72 citations

Biological Weighting Function for RBE Specification of Neutron Therapy Beams. Intercomparison of 9 European Centres

1990 • 71 citations

Biological bases for high rbe values for late effects of neutron irradiation

1982 • 71 citations

Accelerated reoxygenation of a murine fibrosarcoma after carbon-ion radiation

1999 • 70 citations

Chemo-radiotherapy: radiosensitizing nucleoside analogues (review).

1999 • 69 citations

Advances in Radiation Biology

1975 • 68 citations

Biological Indicators for Radiation Damage

1991 • 64 citations

Mouse skin reactions following fractionated irradiation with carbon ions

1998 • 64 citations

Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair

2002 • 63 citations

Thindown in Radiobiology

1985 • 63 citations

Immediate Localized CDKN1A (p21) Radiation Response after Damage Produced by Heavy-Ion Tracks

2000 • 61 citations

DNA complex lesions induced by protons and ⋅ -particles: track structure characteristics determining linear energy transfer and particle type dependence

1997 • 61 citations

Use of Radiation Quality as a Probe for DNA Lesion Complexity

1994 • 61 citations

Changes of fibrosis-related parameters after high- and low-LET irradiation of fibroblasts

2001 • 60 citations

Interaction of Neutrons and Secondary Charged Particles with Tissue: Secondary Particle Spectra

1972 • 58 citations

Laser UV microirradiation of interphase nuclei and post-treatment with caffeine

1976 • 54 citations

Contribution of Base Lesions to Radiation-Induced Clustered DNA Damage: Implication for Models of Radiation Response

2001 • 54 citations

The application of PET to quality assurance of heavy-ion tumor therapy

1999 • 53 citations

Induction of DNA Double-strand Breaks in CHO-K1 Cells by Carbon Ions

1995 • 47 citations

Beam scanning for heavy charged particle radiotherapy

1983 • 47 citations

The Use of Recombinant DNA Techniques to Study Radiation-induced Damage, Repair and Genetic Change in Mammalian Cells

1986 • 47 citations

The role of amifostine as a radioprotector.

2001 • 46 citations

The Radiation Response of Asynchronous Cells at Low Dose: Evidence of Substructure

1991 • 45 citations

Heavy-Ion Radiobiology: Normal Tissue Studies

1983 • 43 citations

Response of a Rat Rhabdomyosarcoma to Neon- and Helium-Ion Irradiation

1978 • 43 citations

The role of higher-order chromatin structure in the yield and distribution of DNA double-strand breaks in cells irradiated with X-rays or α-particles

2000 • 39 citations

Biological Effectiveness of Alpha Particles as a Function of Ion Concentration Produced in their Paths

1935 • 38 citations

Survival of Intestinal Crypt Cells after Exposure to High Z, High-Energy Charged Particles

1980 • 38 citations

The GSI Cancer Therapy Project

1999 • 36 citations

Analysis of chromosome damage based on the time course of aberrations

1998 • 36 citations

Direct Evidence for the Spatial Correlation between Individual Particle Traversals and Localized CDKN1A (p21) Response Induced by High-LET Radiation

2001 • 36 citations

Progress in Low-LET Heavy Particle Therapy: Intracranial and Paracranial Tumors and Uveal Melanomas

1985 • 33 citations

A Monte Carlo calculation of cell inactivation by light ions

1997 • 33 citations

Neoplastic cell transformation by high-LET radiation: Molecular mechanisms

1989 • 32 citations

In Vivo Cell Survival and Volume Response Characteristics of Rat Rhabdomyosarcoma Tumors Irradiated in the Extended Peak Region of Carbon- and Neon-Ion Beams

1980 • 32 citations

Pigmented human skin equivalent—as a model of the mechanisms of control of cell-cell and cell-matrix interactions

1998 • 32 citations

Chemical Radiosensitizers in Cancer Therapy

1992 • 32 citations

Induction and rejoining of DNA double-strand breaks in cho cells after heavy ion irradiation

1996 • 31 citations

Response of Mouse Intestine after Single and Fractionated Irradiation with Accelerated Carbon Ions with a Spread-Out Bragg Peak

1997 • 31 citations

Mutation induction by different types of radiation at the Hprt locus

1999 • 31 citations

Nuclear and atomic data for radiotherapy and related radiobiology

1987 • 31 citations

RBE values for radiation-induced growth delay in rat rhabdomyosarcoma tumors exposed to plateau and peak carbon, neon and argon ions

1981 • 30 citations

Particle track structure and its correlation with radiobiological endpoint

1991 • 30 citations

Analysis of Ar-ion and X-ray-induced chromatin breakage and repair in V79 plateau-phase cells by the premature chromosome condensation technique

2001 • 29 citations

Induction of chromosome aberrations in mammalian cells after heavy ion exposure

1992 • 29 citations

Energy Deposition Clusters in Nanometer Regions of Charged-Particle Tracks

1993 • 28 citations

Histopathological and Morphometric Study of the Late Effects of Heavy-Ion Irradiation on the Spinal Cord of the Rat

1998 • 28 citations

Low-dose hypersensitivity of V79 cells under exposure to γ-rays and 4 He ions of different energies: survival and chromosome aberrations

2001 • 28 citations

Detection of heavy-ion-induced DNA double-strand breaks using static-field gel electrophoresis

1995 • 27 citations

Radiotherapy with Heavy Ions: Radiobiology, Clinical Indications and Experience at GSI, Darmstadt

1998 • 27 citations

Compound Dual Radiation Action: I. General Aspects

1992 • 26 citations

Spot scanning for 250 MeV protons.

1990 • 26 citations

High let: Heavy particle trials

1988 • 26 citations

Calculation of RBE for normal tissue complications based on charged particle track structure

1996 • 25 citations

Thindown in Radiobiology

1985 • 24 citations

Measurement of biological effects of high-energy carbon ions at low doses using a semi-automated cell detection system

2002 • 22 citations

The relation between the exponent of dose response for chromosome aberrations and the relative contribution of “two-track” and “one-track” processes

1965 • 22 citations

Charged-particle mutagenesis II. Mutagenic effects of high energy charged particles in normal human fibroblasts

1994 • 21 citations

Time Course of Reoxygenation in Experimental Murine Tumors after Carbon-beam and X-ray Irradiation

2001 • 20 citations

Acute Response of Pig Skin to Irradiation with 12C-ions or 200 kV X-rays

1997 • 20 citations

Beam delivery systems for charged particles

1992 • 19 citations

The RBE-LET Relationship for Rodent Intestinal Crypt Cell Survival, Testes Weight Loss, and Multicellular Spheroid Cell Survival after Heavy-Ion Irradiation

1992 • 18 citations

Effect of Linear Energy Transfer on Radiation-Induced Chromosome Aberrations in Tradescantia Microspores

1954 • 17 citations

RBE for lung and cord

1982 • 17 citations

The relative biological effectiveness of fast neutrons (42MeVd→Be) for early and late normal tissue injury in the pig

1982 • 16 citations

Fluorescence In Situ Hybridization (FISH) in Genetic Toxicology

2001 • 16 citations

Relative Biological Effectiveness of Carbon Ions for Causing Fatal Liver Failure after Partial Hepatectomy in Mice

2000 • 15 citations

Late Effects of Radiation Therapy

2012 • 15 citations

Similarity between the Effects of Carbon-ion Irradiation and X-irradiation on the Development of Rat Brain

2000 • 13 citations

Molecular radiation biology: Future aspects

1990 • 11 citations

Induction of DNA-Protein Crosslinks in Chinese Hamster V79-4 Cells Exposed to High- and Low-Linear Energy Transfer Radiation

1998 • 10 citations

Response of pig lung to irradiation with accelerated 12 C-ions

1999 • 8 citations

Binary encounter electron emission in collisions of highly charged ions with helium gas targets

1995 • 7 citations

Repopulation Kinetics of Rat Rhabdomyosarcoma Tumors Following Single and Fractionated Doses of Low-LET and High-LET Radiation

1991 • 6 citations