The Use of Recombinant DNA Techniques to Study Radiation-induced Damage, Repair and Genetic Change in Mammalian Cells

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

International Journal of Radiation Biology

1959 • 1,730 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.

1984 • 743 citations

Model for Homologous Recombination During Transfer of DNA into Mouse L Cells: Role for DNA Ends in the Recombination Process

1984 • 457 citations

Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage.

1981 • 415 citations

UV-induced mutation hotspots occur at DNA damage hotspots

1982 • 397 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1983 • 345 citations

High mutation frequency in DNA transfected into mammalian cells.

1983 • 338 citations

gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.

1983 • 319 citations

Enzymatic Restriction of Mammalian Cell DNA Using Pvu II and Bam H1: Evidence for the Double-strand Break Origin of Chromosomal Aberrations

1984 • 313 citations

Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus

1980 • 307 citations

Molecular cloning of a human DNA repair gene

1984 • 307 citations

Molecular mechanisms involved in the production of chromosomal aberrations

1984 • 303 citations

Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells

1983 • 293 citations

Genetic studies of the lac repressor

1977 • 293 citations

Molecular mechanisms involved in the production of cromosomal aberrations II. Utilization of neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle

1980 • 280 citations

Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.

1981 • 252 citations

Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA.

1984 • 251 citations

Sites and structure of gamma radiation-induced DNA strand breaks.

1982 • 249 citations

Range of Radiochemical Damage to DNA with Decay of Iodine-125

1981 • 231 citations

Radiation-Induced Strand Breaks in DNA: Chemical and Enzymatic Analysis of End Groups and Mechanistic Aspects

1981 • 230 citations

Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process.

1984 • 227 citations

Rearrangement and mutagenesis of a shuttle vector plasmid after passage in mammalian cells.

1983 • 207 citations

Strategies and Applications of in Vitro Mutagenesis

1985 • 192 citations

One pyrimidine dimer inactivates expression of a transfected gene in xeroderma pigmentosum cells.

1985 • 189 citations

Sites of inhibition of in vitro DNA synthesis in carcinogen- and UV-treated Φ174 DNA

1979 • 182 citations

Sites of termination of in vitro DNA synthesis on ultraviolet- and N-acetylaminofluorene-treated phi X174 templates by prokaryotic and eukaryotic DNA polymerases.

1981 • 174 citations

Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents.

1985 • 157 citations

Molecular mechanisms involved in the production of chromosomal aberrations

1978 • 152 citations

Deletion and amplification of the HGPRT locus in Chinese hamster cells.

1983 • 147 citations

Enzymatic Restriction of Mammalian Cell DNA: Evidence for Double-strand Breaks as Potentially Lethal Lesions

1985 • 146 citations

Changes in DNA base sequence induced by targeted mutagenesis of lambda phage by ultraviolet light

1984 • 141 citations

Transfected DNA is mutated in monkey, mouse, and human cells.

1984 • 138 citations

Ultraviolet light repair and mutagenesis revisited

1983 • 136 citations

Detection of deletion mutations in pSV2gpt-transformed cells.

1984 • 134 citations

How damaged is the biologically active subpopulation of transfected DNA?

1984 • 124 citations

The British Journal of Cancer

1985 • 122 citations

IS THERE SOS INDUCTION IN MAMMALIAN CELLS?

1980 • 121 citations

Induction of an error-prone mode of DNA repair in UV-irradiated monkey kidney cells

1980 • 120 citations

Specific transcripts are elevated in Saccharomyces cerevisiae in response to DNA damage.

1984 • 111 citations

Hypersensitivity of DNA in transcriptionally active chromatin to ionizing radiation

1982 • 103 citations

Mutations induced by X-rays at the HPRT locus in cultured Chinese hamster cells are mostly large deletions

1985 • 100 citations

Sequence analysis of ultraviolet-induced mutations in M13lacZ hybrid phage DNA

1984 • 96 citations

The molecular nature of mutations in cultured mammalian cells: A review

1985 • 95 citations

Mutagenesis of a shuttle vector plasmid in mammalian cells.

1984 • 94 citations

Double-strand break repair and G2 block in Chinese hamster ovary cells and their radiosensitive mutants

1985 • 94 citations

DNA-mediated genetic transformation of mouse embryos and bone marrow—a review

1985 • 90 citations

Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex

1982 • 85 citations

An Assessment of the Role of Microdosimetry in Radiobiology

1982 • 83 citations

Targeted mutagenesis of SV40 DNA induced by UV light

1983 • 83 citations

Non-targeted mutagenesis of unirradiated lambda phage in Escherichia coli host cells irradiated with ultraviolet light

1984 • 79 citations

Regulated expression of endonuclease EcoRI in Saccharomyces cerevisiae: nuclear entry and biological consequences.

1985 • 78 citations

DNA Repair

1981 • 78 citations

Error-prone mutagenesis detected in mammalian cells by a shuttle vector containing the supF gene of Escherichia coli.

1984 • 75 citations

Molecular identification of a human DNA repair gene following DNA-mediated gene transfer

1983 • 74 citations

Specificity of UV mutagenesis in the lac promoter of M13lac hybrid phage DNA

1982 • 73 citations

In vitro bypass of UV-induced lesions by Escherichia coli DNA polymerase I: specificity of nucleotide incorporation.

1983 • 67 citations

The chromosomes of a V79 Chinese hamster line and a mutant subline lacking HPRT activity

1981 • 63 citations

UV-reactivation, virus production and mutagenesis of SV40 in UV-irradiated monkey kidney cells

1980 • 62 citations

Radiation-induced base substitution mutagenesis in single-stranded DNA phage M13

1981 • 57 citations

Isolation of UV-resistant revertants from a xeroderma pigmentosum complementation group A cell line

1984 • 57 citations

Cloning Vectors Derived from Animal Viruses

1983 • 54 citations

Microinjection of Micrococcus luteus UV-endonuclease restores UV-induced unscheduled DNA synthesis in cells of 9 xeroderma pigmentosum complementation groups

1985 • 52 citations

High Spontaneous Mutation Frequency in Shuttle Vector Sequences Recovered from Mammalian Cellular DNA

1984 • 51 citations

Effect of DNA damage on the expression of the chloramphenicol acetyltransferase gene after transfection into diploid human fibroblasts

1985 • 51 citations

[1] Guide to the use of type II restriction endonucleases

1983 • 50 citations

The British journal of cancer

1986 • 49 citations

CHROMOSOME-MEDIATED GENE TRANSFER IN MAMMALIAN CELLS

1980 • 48 citations

Transcriptionally active and inactive genes are similarly modified by chemical carcinogens or X-ray in normal human fibroblasts

1984 • 46 citations

Use of recombinant DNA techniques in cloning DNA repair genes and in the study of metagenesis in mammalian cells

1985 • 46 citations

Chemical and Biological Consequences of the Radioactive Decay of Iodine-125 in Plasmid DNA

1985 • 45 citations

UV Stimulation of DNA-Mediated Transformation of Human Cells

1985 • 45 citations

DNA-mediated transfer of a human DNA repair gene that controls sister chromatid exchange.

1985 • 45 citations

Enhanced Transformation of Human Cells by UV-Irradiated pSV2 Plasmids

1984 • 44 citations

Inducibility of error-prone DNA repair in yeast?

1984 • 43 citations

The use of a cloned bacterial gene to study mutation in mammalian cells

1983 • 41 citations

Transfection of cells from a xeroderma pigmentosum patient with normal human DNA confers UV resistance

1982 • 41 citations

Indirect induction of mutagenesis of intact parvovirus H-1 in mammalian cells treated with UV light or with UV-irradiated H-1 or simian virus 40.

1981 • 40 citations

UV stimulation of DNA-mediated transformation of human cells.

1985 • 39 citations

Further evidence that ultraviolet radiation-enhanced reactivation of simian virus 40 in monkey kidney cells is not accompanied by mutagenesis

1982 • 39 citations

Enhanced transformation of human cells by UV-irradiated pSV2 plasmids.

1984 • 35 citations

Directed mutagenesis method for analysis of mutagen specificity: application to ultraviolet-induced mutagenesis.

1983 • 33 citations

Sequence Specificity of DNA Cleavage by Micrococcus luteus γ Endonuclease

1985 • 31 citations

The nature of mutants by ionising radiation in cultured hamster cells

1984 • 31 citations

High spontaneous mutation frequency in shuttle vector sequences recovered from mammalian cellular DNA.

1984 • 31 citations

DNA-Mediated Cotransfer of Excision Repair Capacity and Drug Resistance into Chinese Hamster Ovary Mutant Cell Line UV-135

1984 • 30 citations

Sites of Gamma Radiation-induced DNA Strand Breaks after Alkali Treatment

1985 • 28 citations

Quantification of Expression of Linked Cloned Genes in a Simian Virus 40-Transformed Xeroderma Pigmentosum Cell Line

1985 • 25 citations

BLOCKAGE OF RESTRICTION ENDONUCLEASE CLEAVAGE BY THYMINE DIMERS

1982 • 25 citations

Restriction enzyme cleavage of ultraviolet-damaged simian virus 40 and pBR322 DNA

1983 • 25 citations

A Sensitive SV40 Viral Probe Assay for DNA Strand Breaks and Their Biological Repair in Higher Cells: Techniques and Preliminary Results

1985 • 23 citations

The Effect of X-rays and Ultraviolet Light on DNA-mediated Gene Transfer in Mammalian Cells

1984 • 23 citations

Microinjected photoreactivating enzymes from Anacystis and Saccharomyces monomerize dimers in chromatin of human cells

1985 • 21 citations

Transfection with extracellularly UV-damaged DNA induces human and rat cells to express a mutator phenotype towards parvovirus H-1.

1984 • 21 citations

Restriction enzyme cleavage of ultraviolet-damaged DNA

1982 • 20 citations

Enhanced reactivation and mutagenesis after transfection of carcinogen-treated monkey kidney cells with UV-irradiated Simian Virus 40 (SV40) DNA

1982 • 19 citations

DNA-mediated cotransfer of excision repair capacity and drug resistance into chinese hamster ovary mutant cell line UV-135.

1984 • 18 citations

Plasmid rescue — A tool for reproducible recovery of genes from transfected mammalian cells?

1984 • 17 citations

Quantification of expression of linked cloned genes in a simian virus 40-transformed xeroderma pigmentosum cell line.

1985 • 17 citations

Quantitation of the transgenome size in chromosome-mediated gene transfer lines

1985 • 13 citations

Distribution of S1-nuclease Sensitive Sites and Double-strand Breaks in γ-irradiated λ-DNA

1984 • 10 citations

From molecular biology to medicine

1995 • 9 citations

Repair of UV damage in plasmid DNA by human fibroblasts

1984 • 9 citations

Radiation-Induced Inactivation of Single Isolated Genes Mediated by Secondary Radicals

1985 • 7 citations