Invited review Multicell spheroids as a model for cell kinetic studies

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Growth Kinetics of Tumours

1978 • 691 citations

Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas<xref ref-type="fn" rid="FN2">2</xref>

1971 • 580 citations

A simplified method for production and growth of multicellular tumor spheroids.

1977 • 501 citations

Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei.

1977 • 492 citations

Intermittent blood flow in a murine tumor: radiobiological effects.

1987 • 440 citations

Multicellular spheroids

1987 • 427 citations

Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions

1977 • 366 citations

Radiation response of multicell spheroids--an in vitro tumour model.

1976 • 236 citations

Selective dissociation and characterization of cells from different regions of multicell tumor spheroids.

1980 • 202 citations

Spheroids in Cancer Research

1984 • 176 citations

Growth of nodular carcinomas in rodents compared with multi-cell spheroids in tissue culture.

1970 • 131 citations

A comparison of cell proliferation parameters in solid and ascites Ehrlich tumors.

1969 • 126 citations

Oxygen Diffusion Distance and Development of Necrosis in Multicell Spheroids

1979 • 121 citations

Use of Hoechst 33342 for cell selection from multicell systems.

1982 • 120 citations

Proliferation and viability in cellular spheroids of human origin.

1978 • 106 citations

Distribution and Activity of Antineoplastic Drugs in a Tumor Model

1989 • 86 citations

CELL CYCLE KINETICS IN AN IN VITRO TUMOR MODEL

1976 • 83 citations

Interaction of etoposide and cisplatin in an in vitro tumor model.

1987 • 83 citations

Chemosensitivity Testing in V79 Spheroids: Drug Delivery and Cellular Microenvironment<xref ref-type="fn" rid="FN1">2</xref>

1986 • 78 citations

Variable Radiobiological Responses of Spheroids

1980 • 76 citations

Dependence of the radiation response of an in vitro tumor model on cell cycle effects.

1973 • 65 citations

A proliferation gradient in three‐dimensional colonies of cultured human glioma cells

1977 • 62 citations

Colonial Growth in Agar ofcells Derived from Neoplastic and Non-Neoplastic Tissues of Children

1968 • 59 citations

Growth fraction as the major determinant of multicellular tumor spheroid growth rates.

1978 • 57 citations

Tumour spheroid technology in cancer therapy research

1989 • 56 citations

Shedding of mitotic cells from the surface of multicell spheroids during growth

1981 • 54 citations

Development of a 9L Rat Brain Tumor Cell Multicellular Spheroid System and Its Response to 1,3-Bis(2-chloroethyl)-1-nitrosourea and Radiation2

1980 • 53 citations

The Radiation Response of a Human Colon Adenocarcinoma Grown in Monolayer, as Spheroids, and in Nude Mice

1987 • 37 citations

Colonial growth in agar of cells derived from adenovirus-induced hamster tumors.

1967 • 36 citations

Cell Kinetic Characteristics In Different Parts of Multicellular Spheroids of Human Origin

1981 • 32 citations

THE FINE STRUCTURE OF THREE‐DIMENSIONAL COLONIES OF HUMAN GLIOMA CELLS IN AGAROSE CULTURE

1977 • 30 citations

Some observations on the three-dimensional growth of L5178Y cell colonies in soft agar culture

1971 • 28 citations

Oxygen Enhancement Ratio in V79 Spheroids

1983 • 24 citations

Tumor Resistance to Therapy: A Genetic or Kinetic Problem?

1989 • 22 citations

Development of tetraploidy in V79 spheroids

1982 • 20 citations

Physical and nutritional factors in gel culture of mammalian cells

1978 • 11 citations

Misonidazole binding in sccvii tumors in relation to the tumor blood supply

1989 • 11 citations

Dynamics of Cell Kinetic Parameters During 9l Spheroid Growth

1986 • 6 citations