Studies on mammalian mutants defective in rejoining double-strand breaks in DNA

The double-strand-break repair model for recombination

1983 • 2,468 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

The molecular biology of the yeast saccharomyces: Life cycle and inheritance

1982 • 1,361 citations

Linkage map of Escherichia coli K-12, edition 7

1983 • 1,250 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.

1984 • 743 citations

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

1979 • 577 citations

RECOMBINATION DEFICIENT MUTANTS OF E. COLI AND OTHER BACTERIA

1973 • 568 citations

The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control

1976 • 518 citations

The repair of double-strand breaks in DNA: A model involving recombination

1976 • 499 citations

On the nature of hereditable variation in cultured somatic cells

1976 • 497 citations

Genetic analysis of the recF pathway to genetic recombination in Escherichia coli k12: Isolation and characterization of mutants

1973 • 479 citations

A genetic study of X-ray sensitive mutants in yeast

1974 • 478 citations

Changes in X-ray Sensitivity of HeLa Cells during the Division Cycle

1961 • 440 citations

Yeast recombination: the association between double-strand gap repair and crossing-over.

1983 • 432 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

Genetic Studies with Herpes Simplex Virus Type 1. The Isolation of Temperature-sensitive Mutants, their Arrangement into Complementation Groups and Recombination Analysis Leading to a Linkage Map

1973 • 379 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae

1988 • 361 citations

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1983 • 345 citations

Transforming DNA integrates into the host chromosome

1981 • 311 citations

Cellular responses to DNA damage

1983 • 301 citations

THE ROLE OF RADIATION (rad) GENES IN MEIOTIC RECOMBINATION IN YEAST

1980 • 257 citations

Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA.

1984 • 251 citations

The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast.

1980 • 242 citations

DNA Repair and Mutagenesis in Yeast

1981 • 242 citations

Repair of DNA double-strand breaks in Escherichia coli, which requires recA function and the presence of a duplicate genome

1977 • 240 citations

Radiation Induced Strand Breakage in DNA from Mammalian Cells

1973 • 222 citations

EFFECTS OF THE RAD52 GENE ON RECOMBINATION IN SACCHAROMYCES CEREVISIAE

1980 • 220 citations

Mutagenicities of quinoline and its derivatives

1977 • 213 citations

DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. II. Can Cell Death be Attributed to Double Strand Breaks?

1982 • 200 citations

Induction of DNA double-strand breaks by X-rays in a radiosensitive strain of the yeast Saccharomyces cerevisiae

1975 • 199 citations

Somatic Cells Efficiently Join Unrelated DNA Segments End-to-End

1982 • 186 citations

Genetic control of diploid recovery after γ-irradiation in the yeast Saccharomyces cerevisiae

1980 • 185 citations

The Repair of Double-Strand DNA Breaks Correlates with Radiosensitivity of L5178Y-S and L5178Y-R Cells

1987 • 177 citations

Radiation-Sensitive Mutants and Repair in Yeast

1983 • 177 citations

A Chinese hamster ovary cell line hypersensitive to ionizing radiation and deficient in repair replication

1988 • 175 citations

Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell

1983 • 170 citations

Molecular Biology of Aging: Gene Stability and Gene Expression

1986 • 163 citations

Repair of DNA double-strand breaks in Escherichia coli K12 requires a functional recN product

1984 • 162 citations

Mouse Lymphoma Cells with Different Radiosensitivities

1961 • 155 citations

Cell cycle-dependent repair of double-strand DNA breaks in a ?-ray-sensitive Chinese hamster cell

1985 • 150 citations

High-Efficiency Ligation and Recombination of DNA Fragments by Vertebrate Cells

1983 • 148 citations

Recombination During Gene Transfer into Mouse Cells Can Restore the Function of Deleted Genes

1983 • 148 citations

Yeast genetics — Fundamental and applied aspects

1984 • 146 citations

Relative rates of homologous and nonhomologous recombination in transfected DNA.

1985 • 145 citations

Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli.

1983 • 140 citations

Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae.

1988 • 139 citations

Quantitation of the Involvement of the recA, recB, recC, recF, recJ, recN, lexA, radA, radB, uvrD, and umuC Genes in the Repair of X-Ray-Induced DNA Double-Strand Breaks in Escherichia coli

1986 • 136 citations

Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments.

1983 • 129 citations

How damaged is the biologically active subpopulation of transfected DNA?

1984 • 124 citations

Measurement of the Kinetics of DNA Double Strand Break Repair in Ehrlich Ascites Tumour Cells Using the Unwinding Method

1980 • 116 citations

Mutagen-sensitive cell lines are obtained with high frequency in V79 Chinese cells

1987 • 112 citations

Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells.

1986 • 109 citations

Inhibition of HeLa Growth by Intranuclear Tritium

1958 • 97 citations

Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line

1986 • 97 citations

Deficiency in DNA repair in mouse lymphoma strain L5178Y-S.

1987 • 96 citations

Double-strand break repair and G2 block in Chinese hamster ovary cells and their radiosensitive mutants

1985 • 94 citations

Cytological characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6

1987 • 93 citations

Somatic cells efficiently join unrelated DNA segments end-to-end.

1982 • 91 citations

Loss of tumorigenicity with simultaneous changes in radiosensitivity and photosensitivity during in vitro growth of L5178Y murine lymphoma cells.

1983 • 90 citations

Radiation induced DNA double strand breaks are rejoined by ligation and recombination processes

1981 • 86 citations

Effect of double-strand breaks on homologous recombination in mammalian cells and extracts.

1985 • 84 citations

Possibility of the repair of double-strand scissions in DNA caused by gamma-rays

1968 • 84 citations

Ataxia-telangiectasia: a human mutation giving high-frequency misrepair of DNA double-stranded scissions.

1986 • 83 citations

Characterization of an X-ray-hypersensitive mutant of V79 Chinese hamster cells

1988 • 83 citations

The relevance of the nuclear division cycle to radiosensitivity in yeast

1978 • 80 citations

Responses of 4 X-ray-sensitive CHO cell mutants to different radiations and to irradiation conditions promoting cellular recovery

1985 • 80 citations

Abnormal regulation of DNA replication and increased lethality in ataxia telangiectasia cells exposed to carcinogenic agents.

1982 • 76 citations

Different substrate specificities of the two DNA ligases of mammalian cells.

1986 • 73 citations

Cell-cycle-specific repair of DNA double strand breaks in Saccharomyces cerevisiae.

1980 • 71 citations

Double Strand Rejoining in Mammalian DNA

1973 • 69 citations

Relationship between topoisomerase II and radiosensitivity in mouse L5178Y lymphoma strains

1989 • 69 citations

Double-strand gap repair results in homologous recombination in mouse L cells.

1986 • 67 citations

SEPARATION OF LINKED MARKERS IN CHINESE HAMSTER CELL HYBRIDS: MITOTIC RECOMBINATION IS NOT INVOLVED

1978 • 64 citations

High Chromosomal Sensitivity of Chinese Hamster Xrs 5 Cells to Restriction Endonuclease Induced DNA Double-strand Breaks

1987 • 60 citations

Gene recombination in X-ray-sensitive hamster cells.

1987 • 58 citations

Cell-Cycle-Specific Repair of DNA Double-Strand Breaks in Saccharomyces cerevisiae

1980 • 57 citations

Radiosensitive Xrs-5 and Parental CHO Cells Show Identical DNA Neutral Filter Elution Dose—response: Implications for a Relationship between Cell Radiosensitivity and Induction of DNA Double-strand Breaks

1988 • 55 citations

Six complementation groups for ionising-radiation sensitivity in Chinese hamster cells

1988 • 55 citations

The application of the microbial “tooth-pick” technique to somatic cell genetics, and its use in the isolation of X-ray sensitive mutants of chinese hamster ovary cells

1982 • 52 citations

Double strand rejoining in mammalian DNA.

1973 • 51 citations

Kinetics of Double Strand Break Repair in the DNA of X-irradiated Synchronized Mammalian Cells

1983 • 50 citations

Genetic analysis of X-ray-sensitive mutants of the CHO cell line

1985 • 49 citations

Biphasic Survival Curves for XRS Radiosensitive Cells: Subpopulations or Transient Expression of Repair Competence?

1989 • 49 citations

X-ray sensitive mutants of Chinese hamster ovary cell line: radio-sensitivity of DNA synthesis

1985 • 47 citations

Duplex-duplex interactions catalyzed by recA protein allow strand exchanges to pass double-strand breaks in DNA

1984 • 47 citations

DNA Repair Mutants in Higher Eukaryotes

1987 • 46 citations

Quantitation of the repair of gamma-radiation-induced double-strand DNA breaks in human fibroblasts

1981 • 46 citations

Cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells, xrs 5 and xrs 6 IV. Study of chromosomal aberrations and sister-chromatid exchanges by restriction endonucleases and inhibitors of DNA topoisomerase II

1989 • 44 citations

Cell-Cycle-Dependent Repair of Potentially Lethal Damage in the XR-1 γ-Ray-Sensitive Chinese Hamster Ovary Cell

1988 • 44 citations

SENSITIVITY TO PHOTOADDITION OF MONO‐AND BIFUNCTIONAL FUROCOUMARINS OF X‐RAY SENSITIVE MUTANTS OF SACCHAROMYCES CEREVISIAE

1980 • 43 citations

Repair of DNA double-strand breaks in Escherichia coli cells requires synthesis of proteins that can be induced by UV light.

1981 • 42 citations

Molecular recombination and the repair of DNA double-strand breaks in CHO cells

1979 • 42 citations

Genotoxicity of γ-irradiation in L5178Y mouse lymphoma cells

1986 • 39 citations

An Effect of Elevated Postirradiation pH on the Yield of Double-Strand Breaks in DNA from Irradiated Bacterial Cells

1984 • 38 citations

Neutral sucrose gradient sedimentation of very large DNA from Bacillus subtilis

1973 • 37 citations

Vector-mediated DNA double-strand break repair analysis in normal, and radiation-sensitive, Chinese hamster V79 cells

1988 • 37 citations

Identification of a new seventh complementation group of UV-sensitive mutants in Chinese hamster cells

1988 • 36 citations

Homologous recombination in a Chinese hamster X-ray-sensitive mutant

1986 • 36 citations

Interactions among genes controlling sensitivity to radiation (RAD) and to alkylation by nitrogen mustard (SNM) in yeast

1982 • 34 citations

Repair of DNA single-strand and double-strand breaks in the Chinese hamster xrs 5 mutant cell line as determined by DNA unwinding

1988 • 32 citations

Cytological characterization of Chinese hamster ovary X-ray-sensitive mutant cells, xrs 5 and xrs 6

1987 • 30 citations

A search for allelic recombination in Chinese hamster cell hybrids

1977 • 28 citations

The isolation and characterization of an X-ray-sensitive ultraviolet-resistant mutant of Escherichia coli

1971 • 27 citations

The Recombination and Integration of DNAs Introduced into Mouse L Cells

1984 • 26 citations

Molecular biology of DNA repair

1986 • 26 citations

Cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6

1989 • 26 citations

Standardized shake-off to synchronize cultured CHO cells

1983 • 20 citations

Cell-cycle dependent changes in sensitivity to γ-rays in synchronously dividing yeast culture

1974 • 18 citations

Chromosomal Aberrations Induced by X-rays in Two Mouse Lymphoma (L5178Y) Sublines of Different Radiosensitivity

1982 • 17 citations

Recombinational repair of hydrogen peroxide-induced damages in DNA of phage T4

1987 • 17 citations

The Response of L5178Y-R and L5178Y-S Cells to X Rays under Oxic and Hypoxic Conditions

1981 • 15 citations

Normal DNA ligase activity in a γ-ray-sensitive Chinese hamster mutant

1987 • 14 citations

Linkage of the MBG locus to another functionally hemizygous gene locus (IDH2) on chromosome Z3 in Chinese hamster ovary cells.

1985 • 13 citations

rorA mutation of Escherichia coli K-12 affects the recB subunit of exonuclease V

1979 • 12 citations

Interactions Between the MAT locus and the rad52-1 mutation in yeast

1983 • 10 citations

The isolation and preliminary characterisation of a novel Escherichia coli mutant rorB with enhanced sensitivity to ionising radiation

1988 • 8 citations

Failure to Detect a DNA Repair-related Defect in the Transfection of Ataxia-telangiectasia Cells by Enzymatically Restricted Plasmid

1987 • 8 citations