Multicellular tumour spheroids in radiation biology

Rotation-mediated histogenetic aggregation of dissociated cells

1961 • 751 citations

Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas<xref ref-type="fn" rid="FN2">2</xref>

1971 • 580 citations

Multicellular spheroids

1987 • 427 citations

Cell suspensions from organ rudiments of chick embryos

1952 • 383 citations

A study of the mechanics of gastrulation

1944 • 352 citations

Impact of the cyclin–dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

1996 • 328 citations

Effects of intercellular contact on repair of radiation damage

1972 • 287 citations

THE DEVELOPMENT IN VITRO OF CHIMERIC AGGREGATES OF DISSOCIATED EMBRYONIC CHICK AND MOUSE CELLS

1957 • 276 citations

Drug and radiation resistance in spheroids: cell contact and kinetics

1994 • 268 citations

Liquid-Overlay Culture of Cellular Spheroids

1984 • 199 citations

A Multi-component Radiation Survival Curve Using anin VitroTumour Model

1970 • 176 citations

Spheroids in Cancer Research

1984 • 176 citations

Tandem events in myoblast fusion

1977 • 165 citations

Growth and Cellular Characteristics of Multicell Spheroids

1984 • 163 citations

Neural induction in explants which have passed through a sublethal cytolysis

1947 • 148 citations

Increased radioresistance of cells in cultured multicell spheroids. I. Dependence on cellular interaction

1981 • 91 citations

Multicellular Spheroids: A New Model Target for In Vitro Studies of Immunity to Solid Tumor Allografts: Brief Communication

1977 • 48 citations

Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy

1994 • 44 citations

Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [131i] metaiodobenzylguanidine: Implications for the targeted radiotherapy of neuroblastoma

1995 • 41 citations

Changes in myoblast membrane order during differentiation as measured by EPR

1987 • 38 citations

Overview of studies on experimental radioimmunotherapy.

1995 • 37 citations

Differences in Patterns of Aggregation of Malignant and Non-Malignant Mammalian Cells

1966 • 36 citations

Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell lines.

1997 • 36 citations

Radioimmunotherapy of prostatic adenocarcinomas: Effects of ¹³¹I‐labelled E4 antibodies on cells at different depth in DU 145 spheroids

1995 • 34 citations

Differential effects of dose rate and superfractionation on survival and cell cycle of V79 cells from spheroid and monolayer culture

1996 • 33 citations

Radiation-induced apoptosis in human ovarian carcinoma cells growing as a monolayer and as multicell spheroids

1997 • 33 citations

Incorporation of iododeoxyuridine in multicellular glioma spheroids: implications for DNA-targeted radiotherapy using Auger electron emitters

1997 • 33 citations

Prostaglandin binding activity and myoblast fusion in aggregates of avian myoblasts

1986 • 33 citations

Differential regulation of cyclin-dependent kinase inhibitors in monolayer and spheroid cultures of tumorigenic and nontumorigenic fibroblasts.

1998 • 33 citations

pO2- and pH-gradients in multicellular spheroids and their relationship to cellular metabolism and radiation sensitivity of malignant human tumor cells

1994 • 32 citations

Differential cytotoxicity of [123I]IUdR, [125I]IUdR and [131I]IUdR to human glioma cells in monolayer or spheroid culture: effect of proliferative heterogeneity and radiation cross-fire

1998 • 30 citations

Therapeutic effect of m-[131I]- and m-[125I]iodobenzylguanidine on neuroblastoma multicellular tumor spheroids of different sizes.

1996 • 28 citations

Hypofractionated radiation induces a decrease in cell proliferation but no histological damage to organotypic multicellular spheroids of human glioblastomas

1997 • 26 citations

Heterogeneity in the fractionation sensitivities of human tumor cell lines: Studies in a three-dimensional model system

1995 • 24 citations

Cell kinetics and repopulation mechanisms during multifraction irradiation of spheroids

1998 • 22 citations

Cesium ions delay membrane fusion of chick embryo myoblasts in vitro: a conductivity study

1988 • 19 citations

In vitro and in vivo studies on the development of the α-emitting radionuclide bismuth 212 for intraperitoneal use against microscopic ovarian carcinoma

1997 • 18 citations

Determination of the radiobiologically hypoxic fraction in multicellular spheroids from data on the uptake of [3H]fluoromisonidazole.

1995 • 16 citations

In vitro evaluation of Taxol® combined with radiations in human squamous cell carcinoma spheroids

1996 • 16 citations

Radiation Response of Connexin43-Transfected Cells in Relation to the “Contact Effect”

1997 • 15 citations

Dose-dependent Effects of Ionizing Radiation onin VitroMyoblast Fusion

1990 • 14 citations

Studies on aggregation of human ascites tumor cells

1967 • 12 citations

The selection of antibodies for targeted therapy of small-cell lung cancer (SCLC) using a human tumour spheroid model to compare the uptake of cluster 1 and cluster w4 antibodies

1994 • 12 citations

Targeted Radiotherapy of Multicell Neuroblastoma Spheroids with High Specific Activity [125I]Meta-Iodobenzylguanidine

1998 • 10 citations

Association of docetaxel/paclitaxel with irradiation in ovarian carcinoma cell lines in bidimensional (sulforhodamine B assay) and tridimensional (spheroids) cultures

1996 • 8 citations

Cell death induced by a 131I-labeled monoclonal antibody in ovarian cancer multicell spheroids

1996 • 6 citations

Radiotoxic effect and dosimetry of 67Ga in multicellular spheroids as compared to single cells of the lymphoma cell line U715

1996 • 5 citations

The Fusion Radiosensitivity of Differentiating Chick Embryo Myoblastsin VitroIs Not Determined by the Plasma Membrane

1993 • 4 citations

Effects of interferon gamma (IFN gamma) and tumor necrosis factor alpha (TNF alpha) association in intraperitoneal radioimmunotherapy: studies on an in vitro micrometastasis model.

1995 • 4 citations