Functions of U-snRNPs

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

PRE-mRNA SPLICING

1986 • 673 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

1983 • 593 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

1988 • 535 citations

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

1987 • 530 citations

Fibrillarin: a new protein of the nucleolus identified by autoimmune sera

1985 • 488 citations

SPLICEOSOMAL snRNAs

1988 • 463 citations

Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

1988 • 428 citations

Spliceosome assembly in yeast.

1987 • 402 citations

U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus.

1989 • 391 citations

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

1989 • 391 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

1989 • 314 citations

The organization of 3' splice-site sequences in mammalian introns.

1989 • 310 citations

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

1988 • 307 citations

Functions of the Abundant U-snRNPs

1988 • 284 citations

A compensatory base change in human U2 snRNA can suppress a branch site mutation.

1989 • 284 citations

A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA

1986 • 283 citations

A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

1986 • 274 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns

1989 • 267 citations

U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle

1984 • 238 citations

Identification of the Human U7 snRNP as One of Several Factors Involved in the 3′ End Maturation of Histone Premessenger RNA's

1987 • 221 citations

Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing.

1984 • 213 citations

3′ cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNP

1988 • 205 citations

Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation

1988 • 195 citations

Structural analysis of the human U3 ribonucleoprotein particle reveal a conserved sequence available for base pairing with pre-rRNA.

1987 • 190 citations

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.

1988 • 188 citations

Gamma-monomethyl phosphate: a cap structure in spliceosomal U6 small nuclear RNA.

1989 • 185 citations

Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles.

1988 • 183 citations

UACUAAC is the preferred branch site for mammalian mRNA splicing.

1989 • 180 citations

Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions

1987 • 180 citations

A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation.

1987 • 179 citations

Antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides

1989 • 169 citations

An essential yeast snRNA with a U5-like domain is required for splicing in vivo

1987 • 168 citations

Generation of histone mRNA 3′ ends by endonucleolytic cleavage of the pre-mRNA in a snRNP-dependent in vitro reaction.

1986 • 151 citations

20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition.

1989 • 148 citations

Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3′ end of H3 messenger RNA

1986 • 146 citations

3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors.

1984 • 142 citations

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

1986 • 139 citations

Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc.

1988 • 138 citations

U1-Specific Protein C needed for Efficient Complex Formation of U1 snRNP with a 5′ Splice Site

1990 • 135 citations

In vitro assembly of yeast U6 snRNP: a functional assay.

1989 • 134 citations

U5 small nuclear ribonucleoprotein: RNA structure analysis and ATP-dependent interaction with U4/U6.

1989 • 128 citations

The gene for the U6 small nuclear RNA in fission yeast has an intron

1989 • 126 citations

Presplicing complex formation requires two proteins and U2 snRNP.

1988 • 117 citations

Probing the structure and function of U2 snRNP with antisense oligonucleotides made of 2′-OMe RNA

1989 • 115 citations

Multiple factors are required for specific RNA cleavage at a poly(A) addition site.

1988 • 106 citations

Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3′ RNA processing reaction.

1988 • 106 citations

RNA 3′ processing regulates histone mRNA levels in a mammalian cell cycle mutant. A processing factor becomes limiting in G1-arrested cells.

1987 • 104 citations

Functional analysis of mutant Xenopus U2 snRNAs

1989 • 103 citations

Conservation between yeast and man of a protein associated with U5 small nuclear ribonucleoprotein

1989 • 101 citations

Mammalian U2 snRNP has a sequence-specific RNA-binding activity.

1989 • 98 citations

Gel Electrophoretic Isolation of Splicing Complexes Containing U1 Small Nuclear Ribonucleoprotein Particles

1988 • 95 citations

U3 small nuclear RNA can be psoralen-cross-linked in vivo to the 5' external transcribed spacer of pre-ribosomal-RNA.

1989 • 94 citations

Ribonucleoprotein Complex Formation During Pre-mRNA Splicing in Vitro

1986 • 93 citations

In vitro reconstitution of functional yeast U2 snRNPs.

1989 • 91 citations

Structural Analysis of the Human U3 Ribonucleoprotein Particle Reveal a Conserved Sequence Available for Base Pairing with Pre-rRna

1987 • 88 citations

U5 Small Nuclear Ribonucleoprotein: RNA Structure Analysis and ATP-Dependent Interaction with U4/U6

1989 • 85 citations

Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor.

1989 • 78 citations

Both conserved signals on mammalian histone pre-mRNAs associate with small nuclear ribonucleoproteins during 3' end formation in vitro.

1987 • 74 citations

The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome.

1989 • 74 citations

Unusual branch point selection in processing of human growth hormone pre-mRNA.

1988 • 72 citations

Multiple states of U3 RNA in Novikoff hepatoma nucleoli

1984 • 65 citations

Multiple factors are required for poly(A) addition to a mRNA 3' end.

1988 • 65 citations

U2 snRNA sequences that bind U2-specific proteins are dispensable for the function of U2 snRNP in splicing.

1989 • 64 citations

Each of the conserved sequence elements flanking the cleavage site of mammalian histone pre-mRNAs has a distinct role in the 3'-end processing reaction.

1989 • 61 citations

Assembly of Functional U1 and U2 Human-Amphibian Hybrid snRNPs in Xenopus laevis oocytes

1988 • 60 citations

Evidence for nuclear factors involved in recognition of 5′ splice sites

1989 • 43 citations

Ribonucleoprotein complex formation during pre-mRNA splicing in vitro.

1986 • 42 citations

In vitro reconstitution of snRNPs: a reconstituted U4/U6 snRNP participates in splicing complex formation.

1989 • 40 citations

Small nuclear ribonucleo-protein particles

1989 • 36 citations

Evidence from complementation assays in vitro that U5 snRNP is required for both steps of mRNA splicing.

1989 • 36 citations

Both Conserved Signals on Mammalian Histone Pre-mRNAs Associate with Small Nuclear Ribonucleoproteins During 3′ end Formation in Vitro

1987 • 36 citations

Three distinct activities possibly involved in mRNA splicing are found in a nuclear fraction lacking U1 and U2 RNA

1986 • 32 citations

Each of the Conserved Sequence Elements Flanking the Cleavage Site of Mammalian Histone Pre-mRNAs Has a Distinct Role in the 3′-End Processing Reaction

1989 • 30 citations

Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiationin situ

1988 • 28 citations

B-B′ proteins from small nuclear ribonucleoproteins have an endoribonuclease catalytic domain inactive in native particles

1989 • 4 citations