Both conserved signals on mammalian histone pre-mRNAs associate with small nuclear ribonucleoproteins during 3' end formation in vitro.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus

1979 • 1,178 citations

Splicing of Messenger RNA Precursors

1984 • 874 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

1983 • 593 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

The organization and expression of histone gene families

1981 • 501 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

SnRNAs, SnRNPs, and RNA Processing

1982 • 458 citations

The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies.

1984 • 371 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

The 3′ Splice Site of Pre-Messenger RNA Is Recognized by a Small Nuclear Ribonucleoprotein

1985 • 310 citations

A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA

1986 • 283 citations

Site-specific polyadenylation in a cell-free reaction

1984 • 223 citations

Pre-mRNA splicing in vitro requires intact U4/U6 small nuclear ribonucleoprotein

1986 • 222 citations

U1, U2, and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylation

1986 • 192 citations

The cDNA sequences of the sea urchin U7 small nuclear RNA suggest specific contacts between histone mRNA precursor and U7 RNA during RNA processing.

1984 • 173 citations

Biochemical complementation with RNA in the Xenopus oocyte: A small rna is required for the generation of 3′ histone mRNA termini

1983 • 165 citations

Cap-dependent RNA splicing in a HeLa nuclear extract.

1985 • 156 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

Generation of histone mRNA 3′ ends by endonucleolytic cleavage of the pre-mRNA in a snRNP-dependent in vitro reaction.

1986 • 151 citations

Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3′ end of H3 messenger RNA

1986 • 146 citations

Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes.

1987 • 143 citations

3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors.

1984 • 142 citations

Compilation analysis of histones and histone genes

1986 • 141 citations

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

1986 • 139 citations

Generation of authentic 3′ termini of an H2A mRNA in vivo is dependent on a short inverted DNA repeat and on spacer sequences

1982 • 139 citations

The terminal RNA stem-loop structure and 80 bp of spacer DNA are required for the formation of 3′ termini of sea urchin H2A mRNA

1983 • 137 citations

Formation of the 3′ end of histone mRNA by post-transcriptional processing

1984 • 129 citations

The primary structure and expression of four cloned human histone genes

1983 • 120 citations

The conserved CAAGAAAGA spacer sequence is an essential element for the formation of 3′ termini of the sea urchin H3 histone mRNA by RNA processing.

1985 • 99 citations

Transcription of human histone genes in extracts from synchronized HeLa cells.

1984 • 97 citations

Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3′ processing of H3 pre-mRNA in the oocyte.

1986 • 96 citations

Differential expression of two clusters of mouse histone genes

1985 • 87 citations

Multiple Interactions between the Splicing Substrate and Small Nuclear Ribonucleoproteins in Spliceosomes

1987 • 86 citations

A regulatory sequence near the 3′ end of sea urchin histone genes

1979 • 86 citations

Processing and nucleo-cytoplasmic transport of histone gene transcripts

1984 • 79 citations

Small Ribonucleoproteins from Eukaryotes: Structures and Roles in RNA Biogenesis

1983 • 75 citations

5'-terminal caps of snRNAs are accessible for reaction with 2,2,7-trimethylguanosine-specific antibody in intact snRNPs.

1983 • 66 citations

Sequences of four mouse histone H3 genes: Implications for evolution of mouse histone genes

1986 • 64 citations

The 3′ end of Drosophila histone H3 mRNA is produced by a processing activity in vitro

1984 • 60 citations