Functions of Human Papillomavirus Proteins

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

1984 • 1,308 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Human papillomaviruses in the pathogenesis of anogenital cancer

1991 • 855 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Heterogeneity of the human papillomavirus group

1989 • 677 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A

1988 • 657 citations

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

1992 • 617 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1993 • 537 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

The Physical State of Human Papillomavirus Type 16 DNA in Benign and Malignant Genital Tumours

1985 • 480 citations

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1991 • 464 citations

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator

1990 • 396 citations

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins

1992 • 389 citations

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.

1992 • 375 citations

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

1987 • 351 citations

Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.

1987 • 345 citations

Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

1992 • 344 citations

Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA

1987 • 330 citations

Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis.

1987 • 327 citations

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.

1992 • 327 citations

Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18

1990 • 319 citations

Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.

1992 • 315 citations

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

1983 • 313 citations

Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins.

1992 • 302 citations

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1987 • 294 citations

Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells.

1988 • 284 citations

Activation of BPV-1 replication in vitro by the transcription factor E2

1991 • 284 citations

The papillomavirus E2 regulatory proteins.

1991 • 276 citations

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.

1992 • 272 citations

Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA

1990 • 270 citations

Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products.

1992 • 269 citations

The Role of Papillomaviruses in Human Anogenital Cancer

1987 • 267 citations

Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters

1990 • 265 citations

Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1.

1991 • 257 citations

A point mutational analysis of human papillomavirus type 16 E7 protein

1989 • 241 citations

Papillomavirus polypeptides E6 and E7 are zinc-binding proteins

1989 • 239 citations

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1992 • 233 citations

The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes

1989 • 218 citations

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture

1991 • 216 citations

Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.

1993 • 200 citations

The retinoblastoma protein and the regulation of cell cycling

1992 • 198 citations

Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata

1987 • 197 citations

Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome.

1989 • 195 citations

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells

1991 • 182 citations

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

1992 • 177 citations

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

1992 • 177 citations

Transient replication of human papillomavirus DNAs

1992 • 177 citations

HPV16 E7 protein associates with the protein kinase p33CDK2 and cyclin A.

1993 • 141 citations

A common function for polyoma virus large-T and papillomavirus E1 proteins?

1984 • 133 citations

Functional analysis of E2-mediated repression of the HPV18 P105 promoter.

1991 • 132 citations

Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein.

1993 • 128 citations

Papillomavirus DNA replication

1991 • 127 citations

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein

1993 • 118 citations

Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells.

1992 • 99 citations

A bovine papillomavirus E1-related protein binds specifically to bovine papillomavirus DNA

1991 • 98 citations

Single amino acid substitutions in "low-risk" human papillomavirus (HPV) type 6 E7 protein enhance features characteristic of the "high-risk" HPV E7 oncoproteins.

1992 • 89 citations

E6 protein of human papillomavirus type 18 binds zinc.

1989 • 65 citations

Characterization of a cell type-specific enhancer found in the human papilloma virus type 18 genome.

1987 • 64 citations

Intracellular localization and DNA-binding properties of human papillomavirus type 18 E6 protein expressed with a baculovirus vector

1989 • 63 citations

Identification of bovine papillomavirus E1 mutants with increased transforming and transcriptional activity

1989 • 61 citations

Bovine papillomavirus type 1 E1 replication-defective mutants are altered in their transcriptional regulation

1988 • 56 citations

Repression of bovine papillomavirus type 1 transcription by the E1 replication protein

1993 • 45 citations

Expression of human papillomavirus type 16 E7 gene induces DNA synthesis of rat 3Y1 cells

1989 • 39 citations

Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product.

1992 • 38 citations

Identification and characterization of novel promoters in the genome of human papillomavirus type 18

1993 • 26 citations