Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

1989 • 1,345 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.

1989 • 913 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

Epidermal differentiation: the bare essentials.

1990 • 651 citations

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

1991 • 512 citations

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1991 • 507 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.

1986 • 440 citations

Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18

1990 • 319 citations

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

1988 • 298 citations

p53 point mutation in HPV negative human cervical carcinoma cell lines.

1991 • 271 citations

The Role of Papillomaviruses in Human Anogenital Cancer

1987 • 267 citations

Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.

1987 • 230 citations

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture

1991 • 216 citations

Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA.

1988 • 200 citations

Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in situ hybridization

1987 • 184 citations

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells

1991 • 182 citations

Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells

1981 • 177 citations

Molecular basis for heterogeneity of the human p53 protein.

1986 • 167 citations

In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential

1991 • 150 citations

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity

1992 • 72 citations

The role of papillomaviruses in anogenital cancer.

1990 • 64 citations

Molecular Basis for Heterogeneity of the Human p53 Protein

1986 • 58 citations

Stability of p53 protein in rat cells transformed by various viral transforming genes

1992 • 11 citations