Molecular Analysis and Possible Pleiotropic Function(s) of the T Cell-Specific Serine Proteinase-1 (TSP-1)

Adhesion receptors of the immune system

1990 • 6,585 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

The Interferon System

1979 • 1,035 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

Keratinocytes as initiators of inflammation

1991 • 756 citations

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.

1991 • 693 citations

Adhesion molecules controlling lymphocyte migration

1989 • 654 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

Interleukin 2

1984 • 497 citations

Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells

1980 • 424 citations

Role of proteolytic enzymes in biological regulation (a review).

1976 • 410 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Adhesive protein receptors on hematopoietic cells

1988 • 350 citations

Structure and function of human perforin

1988 • 346 citations

Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase

1984 • 344 citations

Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions.

1991 • 343 citations

Dual role of the CD44 molecule in T cell adhesion and activation.

1989 • 335 citations

Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation

1990 • 322 citations

A novel serine esterase expressed by cytotoxic T lymphocytes

1985 • 319 citations

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

1986 • 316 citations

Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations.

1990 • 303 citations

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.

1989 • 291 citations

Degradation of type IV (basement membrane) collagen by a proteinase isolated from human polymorphonuclear leukocyte granules.

1980 • 279 citations

Granzymes, a Family of Serine Proteases Released from Granules of Cytolytic T Lymphocytes upon T Cell Receptor Stimulation

1988 • 263 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Cloning of a cDNA for a T Cell-Specific Serine Protease from a Cytotoxic T Lymphocyte

1986 • 247 citations

Novel Serine Proteases Encoded by Two Cytotoxic T Lymphocyte-Specific Genes

1986 • 246 citations

Serine esterase in cytolytic T lymphocytes

1986 • 240 citations

Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.

1987 • 236 citations

Split-gene evolution: Exon shuffling and intron insertion in serine protease genes

1985 • 217 citations

T Cell Response to Viral and Bacterial Infection

1974 • 197 citations

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14

1986 • 197 citations

Proteolytic processing and physiological regulation

1989 • 195 citations

Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.

1989 • 186 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall.

1989 • 183 citations

The molecular mechanism of lymphocyte-mediated tumor cell lysis

1985 • 183 citations

Specific Cell-Adhesion Mechanisms Determining Migration Pathways of Recirculating Lymphocytes

1987 • 181 citations

Isolation and characterization of a serine esterase from cytolytic T cell granules

1986 • 177 citations

CTL: virus control cells first and cytolytic cells second? DNA fragmentation, apoptosis and the prelytic halt hypothesis

1989 • 169 citations

Collagen reduces glycosaminoglycan degradation by cultured mammary epithelial cells: possible mechanism for basal lamina formation.

1979 • 164 citations

Fibronectin: A Brief Overview of Its Structure, Function, and Physiology

1987 • 161 citations

The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases.

1980 • 155 citations

Granules of cytolytic T-lymphocytes contain two serine esterases.

1986 • 148 citations

Structure of the human neutrophil elastase gene.

1988 • 142 citations

The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate

1988 • 142 citations

Cell specificity of granzyme gene expression.

1990 • 136 citations

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1990 • 134 citations

A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.

1988 • 130 citations

Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes.

1987 • 128 citations

Genomic Organization and Chromosomal Localization of the Human Cathepsin G Gene

1989 • 126 citations

Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family.

1987 • 122 citations

Transient expression of type IV collagenolytic metalloproteinase by human mononuclear phagocytes.

1986 • 122 citations

Proteases as mitogens

1974 • 119 citations

Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.

1988 • 118 citations

Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.

1988 • 117 citations

Cloning and structural analysis of MMCP‐1, MMCP‐4 and MMCP‐5, three mouse mast cell‐specific serine proteases

1991 • 116 citations

Identification and molecular cloning of a novel mouse mucosal mast cell serine protease.

1990 • 115 citations

Characterization of three serine esterases isolated from human IL-2 activated killer cells.

1988 • 114 citations

Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.

1986 • 112 citations

Stimulation of Mouse B Lymphocytes by Trypsin

1974 • 108 citations

Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes.

1980 • 105 citations

Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix

1987 • 100 citations

Thrombin-stimulated cell division involves proteolysis of its cell surface receptor

1979 • 99 citations

Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes.

1988 • 92 citations

Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.

1988 • 91 citations

Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes.

1986 • 91 citations

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.

1987 • 86 citations

Granzyme A and perforin as markers for rejection in cardiac transplantation

1991 • 81 citations

Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus

1989 • 81 citations

Mouse T-cell associated serine proteinase 1 degrades collagen type IV: a structural basis for the migration of lymphocytes through vascular basement membranes.

1991 • 77 citations

The killing of mouse trophoblast cells by granulated metrial gland cells in vitro

1988 • 75 citations

Are proteinases functional molecules of T lymphocytes?

1987 • 74 citations

Cloned cytolytic T-effector cells and their malignant variants produce an extracellular matrix degrading trypsin-like serine proteinase.

1987 • 68 citations

Identification of granzyme A isolated from cytotoxic T‐lymphocyte‐granules as one of the proteases encoded by CTL‐specific genes

1986 • 68 citations

Activation of pro‐urokinase by the human T cell‐associated serine proteinase HuTSP‐1

1990 • 67 citations

The Interferon System

1981 • 65 citations

A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.

1990 • 65 citations

Structure and evolutionary origin of the human granzyme H gene

1991 • 61 citations

Characterization and isolation of a trypsin-like serine protease from a long-term culture cytolytic T cell line and its expression by functionally distinct T cells.

1986 • 59 citations

cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes.

1988 • 57 citations

Isolation and complete structure of the lymphocyte serine protease granzyme G, a novel member of the granzyme multigene family in murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte proteases

1989 • 56 citations

Cloning of a gene that encodes a new member of the human cytotoxic cell protease family

1990 • 55 citations

A novel serine proteinase (HuTSP) isolated from a cloned human CD8⁺ cytolytic T cell line is expressed and secreted by activated CD4⁺ and CD8⁺ lymphocytes

1987 • 54 citations

The Role of Extracellular Proteases in Cell Proliferation and Differentiation

1989 • 49 citations

Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity.

1988 • 49 citations

Immunogold labeling of perform and serine esterases in granulated metrial gland cells

1991 • 47 citations

Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes

1989 • 45 citations

In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C

1991 • 44 citations

Inactivation of human interleukin-2 (IL-2) by alpha 2-macroglobulin-trypsin complexes.

1986 • 42 citations

Expression of cytoplasmic granules with T cell‐associated serine proteinase‐1 activity in Ly‐2(CD8) T lymphocytes responding to lymphocytic choriomeningitis virus in vivo

1989 • 41 citations

Organization of two genes encoding cytotoxic T lymphocyte-specific serine proteases CCPI and CCPII

1988 • 39 citations

Appearance of granule-associated molecules during activation of cytolytic T-lymphocyte precursors by defined stimuli.

1988 • 38 citations

Inhibition of lymphocyte protease granzyme A by antithrombin III

1988 • 38 citations

Evidence for the involvement of a T-cell-associated serine proteinase (TSP-1) in cell killing

1987 • 37 citations

Transcriptional activation of the human cytotoxic serine protease gene CSP-B in T lymphocytes.

1990 • 37 citations

Immunohistochemical localization of granzyme B antigen in cytotoxic cells in human tissues.

1991 • 35 citations

Isolation and sequence analysis of serine protease cDNAs from mouse cytolytic T lymphocytes.

1988 • 34 citations

Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.

1988 • 34 citations

The mechanism of cell-mediated cytotoxicity

1982 • 30 citations

Effect of protease inhibitors on mitogen stimulation of hamster lymphoid cells

1976 • 30 citations

Release of biologically active fragments from human plasma-fibronectin by murine T cell-specific proteinase 1 (TSP-1).

1988 • 29 citations

Lymphocyte Adhesion to Endothelial Cells in Vitro: Models for the Study of Normal Lymphocyte Recirculation and Lymphocyte Emigration into Chronic Inflammatory Lesions

1989 • 29 citations

Structural organization of the hCTLA-1 gene encoding human granzyme B

1990 • 29 citations

A secretable serine proteinase with highly restricted specificity from cytolytic T lymphocytes inactivates retrovirus‐associated reverse transcriptase

1987 • 29 citations

An inhibitor specific for the mouse T‐cell associated serine proteinase 1 (TSP‐1) inhibits the cytolytic potential of cytoplasmic granules but not of intact cytolytic T cells

1989 • 28 citations

Characterization of a novel, human cytotoxic lymphocyte‐specific serine protease cDNA clone (CSP‐C)**

1990 • 26 citations

Isolation of two cDNA sequences which encode cytotoxic cell proteases

1988 • 25 citations

Genomic organization and subchromosomal in situ localization of the murine granzyme F, a serine protease expressed in CD8+ T cells.

1991 • 25 citations

The T cell‐specific serine proteinase TSP‐1 is associated with cytoplasmic granules of cytolytic T lymphocytes

1987 • 24 citations

Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes

1990 • 23 citations

Granzyme B-gene expression: a marker of human lymphocytes “activated” in vitro or in renal allografts

1990 • 21 citations

Protease bypass of temperature-sensitive murine leukemia virus maturation mutants

1982 • 18 citations

Organ-Specific and Non-Organ-Specific Lymphocyte Receptors for Vascular Endothelium

1990 • 18 citations

In situ localization of HuHF serine protease mRNA and cytotoxic cell-associated antigens in human dermatoses. A novel method for the detection of cytotoxic cells in human tissues.

1988 • 18 citations

Induction of T cell serine proteinase 1 (TSP‐1)‐specific mRNA in mouse T lymphocytes

1988 • 15 citations

Expression of T-cell-associated serine proteinase 1 during murine Leishmania major infection correlates with susceptibility to disease

1991 • 15 citations

Organization of the gene encoding the mouse T-cell-specific serine proteinase “granzyme A”

1992 • 14 citations

Structure and evolution of the cytotoxic cell proteinase genes CCP3, CCP4 and CCP5

1991 • 14 citations

Determination of frequency of T cells expressing the T cell‐specific serine proteinase 1 (TSP‐1) reveals two types of L3T4⁺ T lymphocytes

1988 • 12 citations

Coordinate secretion and functional synergism of T cell-associated serine proteinase-1 (MTSP-1) and endoglycosidase(s) of activated T cells

1991 • 12 citations

Fibroblast matrix and surface components that mediate cell-to-cell interaction with lymphocytes

1989 • 11 citations

Protease nexin-1 complexes and inhibits T cell serine proteinase-1

1989 • 10 citations

Regulation of mouse T cell associated serine proteinase-1 (MTSP-1) by proteinase inhibitors and sulfated polysaccharides.

1990 • 9 citations

How do cytotoxic T lymphocytes work in vivo?

1987 • 7 citations

Human T cell specific proteinase (HuTSP) is encoded by the T cell and natural killer cell specific human Hanukah factor (HuHF) gene

1988 • 7 citations

Expression of two serine esterase genes during an allograft rejection in the mouse.

1988 • 3 citations

Deleted Work

1955 • 0 citations