Characterization of a novel, human cytotoxic lymphocyte‐specific serine protease cDNA clone (CSP‐C)**

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Current protocols in molecular biology

1988 • 7,584 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

Glycoproteins

1972 • 582 citations

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

1985 • 398 citations

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1987 • 393 citations

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

1986 • 316 citations

Cloning of a cDNA for a T Cell-Specific Serine Protease from a Cytotoxic T Lymphocyte

1986 • 247 citations

Novel Serine Proteases Encoded by Two Cytotoxic T Lymphocyte-Specific Genes

1986 • 246 citations

Serine esterase in cytolytic T lymphocytes

1986 • 240 citations

Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes.

1987 • 236 citations

Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases

1987 • 218 citations

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14

1986 • 197 citations

Isolation and characterization of a serine esterase from cytolytic T cell granules

1986 • 177 citations

Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin

1987 • 158 citations

The mechanism of cell-mediated cytotoxicity. I. Killing by murine cytotoxic T lymphocytes requires cell surface thiols and activated proteases.

1980 • 155 citations

Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis.

1985 • 149 citations

Granules of cytolytic T-lymphocytes contain two serine esterases.

1986 • 148 citations

Inhibition of human natural cytotoxicity by macromolecular antiproteases.

1981 • 147 citations

Perforin and serine esterase gene expression in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.

1989 • 144 citations

A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.

1988 • 130 citations

Genomic Organization and Chromosomal Localization of the Human Cathepsin G Gene

1989 • 126 citations

Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family.

1987 • 122 citations

Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease.

1988 • 118 citations

Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes.

1988 • 117 citations

Characterization of three serine esterases isolated from human IL-2 activated killer cells.

1988 • 114 citations

Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes.

1986 • 112 citations

Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes.

1980 • 105 citations

Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus.

1988 • 93 citations

Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes.

1988 • 92 citations

Molecular cloning of an inducible serine esterase gene from human cytotoxic lymphocytes.

1988 • 91 citations

Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus

1989 • 81 citations

Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes

1988 • 80 citations

T cell receptor alpha chain genes are located on chromosome 14 at 14q11-14q12 in humans.

1985 • 77 citations

The requirement for proteinase activity for human lymphocyte-mediated natural cytotoxicity (NK): evidence that the proteinase is serine dependent and has aromatic amino acid specificity of cleavage.

1984 • 72 citations

A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.

1990 • 65 citations

A complex of serine protease genes expressed preferentially in cytotoxic T-lymphocytes is closely linked to the T-cell receptor α- and δ-chain genes on mouse chromosome 14

1990 • 58 citations

cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes.

1988 • 57 citations

Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases

1988 • 56 citations

A novel serine proteinase (HuTSP) isolated from a cloned human CD8⁺ cytolytic T cell line is expressed and secreted by activated CD4⁺ and CD8⁺ lymphocytes

1987 • 54 citations

IL-2 induces expression of serine protease enzymes and genes in natural killer and nonspecific T killer cells.

1989 • 53 citations

Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes

1989 • 45 citations

Proximity of the CTLA-1 serine esterase and Tcr ? loci in mouse and man

1988 • 39 citations

RNKP-1, a novel natural killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes.

1990 • 37 citations

Structure and differential mechanisms of regulation of expression of a serine esterase gene in activated human T lymphocytes.

1988 • 34 citations

Isolation and sequence analysis of serine protease cDNAs from mouse cytolytic T lymphocytes.

1988 • 34 citations

Localization, implications for function, and gene expression of chymotrypsin-like proteinases of cytotoxic RNK-16 lymphocytes

1988 • 14 citations

Cytotoxic Effector Mechanisms

1989 • 11 citations

Cytotoxic effector mechanisms

1990 • 2 citations