Cellular and Molecular Mechanisms of Postmenopausal Osteoporosis

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.

1998 • 1,705 citations

Principles of Bone Biology

2019 • 1,699 citations

Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

1995 • 1,661 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Principles of Bone Biology

1997 • 1,367 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Osteonal and hemi‐osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone

1994 • 968 citations

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β

1996 • 799 citations

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.

1994 • 738 citations

PREVENTION OF SPINAL OSTEOPOROSIS IN OOPHORECTOMISED WOMEN

1980 • 705 citations

Transforming Growth Factor‐β

1990 • 696 citations

17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.

1992 • 685 citations

Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines

1998 • 585 citations

Advances in Bone Biology: The Osteoclast*

1996 • 522 citations

Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.

1995 • 440 citations

Function of osteocytes in bone

1994 • 402 citations

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.

1995 • 396 citations

The Death of Osteocytes via Apoptosis Accompanies Estrogen Withdrawal in Human Bone*

1997 • 386 citations

Outpatient Waiting Time

1963 • 371 citations

Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype.

1996 • 364 citations

Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.

1996 • 345 citations

Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.

1994 • 341 citations

Essential Requirement of BMPs-2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin

2000 • 319 citations

Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency.

1997 • 306 citations

The Role of Estrogen in the Control of Rat Osteocyte Apoptosis

1998 • 305 citations

Estrogen Deficiency Increases the Ability of Stromal Cells to Support Murine Osteoclastogenesis via an Interleukin-1and Tumor Necrosis Factor-mediated Stimulation of Macrophage Colony-stimulating Factor Production

1996 • 278 citations

17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.

1994 • 276 citations

Transcriptional Activation of the p21 Gene by Interleukin-6 Type Cytokines

1998 • 227 citations

Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption.

1998 • 215 citations

Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation*

1997 • 206 citations

The Death of Osteocytes via Apoptosis Accompanies Estrogen Withdrawal in Human Bone

1997 • 174 citations

Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.

1996 • 171 citations

Bone remodeling and its relationship to metabolic bone diseases

1973 • 165 citations

Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance.

1996 • 137 citations

Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow.

1997 • 129 citations

In Vitro Secretion of Cytokines by Human Bone Marrow: Effects of Age and Estrogen Status1

1998 • 126 citations

The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage*

1997 • 125 citations

Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding sites in interleukin-6 promoter inhibition by estrogens.

1996 • 112 citations

Apoptosis in bone physiology and disease.

1997 • 109 citations

The Effects of Orbital Spaceflight on Bone Histomorphometry and Messenger Ribonucleic Acid Levels for Bone Matrix Proteins and Skeletal Signaling Peptides in Ovariectomized Growing Rats*

1997 • 91 citations

Bone Remodeling and its Relationship to Metabolic Bone Diseases

1973 • 87 citations

Osteopontin Expression by Osteoclast and Osteoblast Progenitors in the Murine Bone Marrow: Demonstration of Its Requirement for Osteoclastogenesis and Its Increase After Ovariectomy*

1997 • 86 citations

Constitutive expression of leukemia inhibitory factor RNA by human bone marrow stromal cells and modulation by IL-1, TNF-alpha, and TGF-beta.

1991 • 85 citations

In Vitro Secretion of Cytokines by Human Bone Marrow: Effects of Age and Estrogen Status

1998 • 78 citations

Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the alpha receptor-specific up-regulation

1991 • 61 citations

Short-term local injections of transforming growth factor-β1 decrease ovariectomy-stimulated osteoclastic resorption in vivo in rats

1995 • 49 citations

Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone

1997 • 46 citations

Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding sites in interleukin-6 promoter inhibition by estrogens

1996 • 40 citations

Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance

1996 • 37 citations

Effect of tumor necrosis factor-α on the expression of insulin-like growth factor I and insulin-like growth factor binding protein 4 in mouse osteoblasts

1994 • 37 citations

Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation

1997 • 35 citations

IL-1 down-regulates platelet-derived growth factor-alpha receptor gene expression at the transcriptional level in human osteoblastic cells.

1994 • 31 citations

The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage

1997 • 27 citations

Osteopontin Expression by Osteoclast and Osteoblast Progenitors in the Murine Bone Marrow: Demonstration of Its Requirement for Osteoclastogenesis and Its Increase After Ovariectomy

1997 • 17 citations

The Effects of Orbital Spaceflight on Bone Histomorphometry and Messenger Ribonucleic Acid Levels for Bone Matrix Proteins and Skeletal Signaling Peptides in Ovariectomized Growing Rats

1997 • 16 citations

Impaired intramembranous bone formation in connexin43 null mice

1998 • 13 citations