Analysis of the molecular pharmacology of estrogen receptor agonists and antagonists provides insights into the mechanism of action of estrogen in bone

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

Effects of Tamoxifen on Bone Mineral Density in Postmenopausal Women with Breast Cancer

1992 • 1,139 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

1995 • 756 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

1995 • 665 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

1993 • 524 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

1992 • 468 citations

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

1990 • 400 citations

Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women

1991 • 380 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Female sex steroids: receptors and function.

1979 • 273 citations

Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation.

1992 • 271 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

Identification of a New Subclass of Alu DNA Repeats Which Can Function as Estrogen Receptor-dependent Transcriptional Enhancers

1995 • 226 citations

The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex

1990 • 223 citations

The Mechanism of ICI 164,384 Antiestrogenieity Involves Rapid Loss of Estrogen Receptor in Uterine Tissue

1991 • 201 citations

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

1993 • 186 citations

Female Sex Steroids

1979 • 152 citations

Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: A model to study the tumoristatic action of tamoxifen

1988 • 147 citations

Molecular endocrinology 2

1995 • 146 citations

3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic Acid: A Non-Steroidal Estrogen with Functional Selectivity for Bone over Uterus in Rats

1994 • 144 citations

Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity.

1996 • 139 citations

Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance.

1996 • 137 citations

Action of ?pure? antiestrogens in inhibiting estrogen receptor action

1993 • 135 citations

Specific mutations in the estrogen receptor change the properties of antiestrogens to full agonists.

1995 • 127 citations

Mechanism of estrogen receptor-dependent transcription in a cell-free system.

1990 • 84 citations

In situ distinction between steroid receptor binding and transactivation at a target gene.

1991 • 82 citations

The strategic use of antiestrogens to control the development and growth of breast cancer.

1992 • 77 citations

Effects of a non-steroidal pure antioestrogen, ZM 189,154, on oestrogen target organs of the rat including bones

1994 • 66 citations

Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity [published erratum appears in Mol Endocrinol 1997 Mar;11(3):341]

1996 • 60 citations

Definition of the cellular mechanisms which distinguish between hormone and antihormone activated steroid receptors.

1994 • 33 citations

Droloxifene inhibits cortical bone turnover associated with estrogen deficiency in rats

1995 • 18 citations

Development of Tissue-Selective Estrogen Receptor Modulators

1995 • 13 citations