Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

The ovariectomized rat model of postmenopausal bone loss

1991 • 1,345 citations

LONG-TERM PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS BY ŒSTROGEN

1976 • 946 citations

OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

1988 • 943 citations

OUTCOME FOR INFANTS OF VERY LOW BIRTHWEIGHT: SURVEY OF WORLD LITERATURE

1981 • 829 citations

17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.

1992 • 685 citations

Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells.

1991 • 558 citations

Menopausal changes in bone remodeling.

1978 • 436 citations

Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

1991 • 419 citations

Estradiol Effects on Proliferation, Messenger Ribonucleic Acid for Collagen and Insulin-like Growth Factor-I, and Parathyroid Hormone-Stimulated Adenylate Cyclase Activity in Osteoblastic Cells from Calvariae and Long Bones

1989 • 369 citations

Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone.

1992 • 363 citations

Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.

1990 • 343 citations

Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma.

1991 • 256 citations

Stimulation of murine hemopoietic colony formation by human IL-6.

1988 • 237 citations

Identification of Committed Mononuclear Precursors for Osteoclast-Like Cells Formed in Long Term Human Marrow Cultures*

1990 • 232 citations

Tamoxifen Inhibits Osteoclast-Mediated Resorption of Trabecular Bone in Ovarian Hormone-Deficient Rats*

1988 • 224 citations

Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats.

1990 • 186 citations

Induction of Calcitonin Receptors by lα, 25- Dihydroxyvitamin D₃in Osteoclast-Like Multinucleated Cells Formed from Mouse Bone Marrow Cells*

1988 • 169 citations

Endotoxin-induced cytokine gene expression in vivo. III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6.

1991 • 154 citations

Calcitonin Receptors as Markers for Osteoclastic Differentiation: Correlation between Generation of Bone-Resorptive Cells and Cells that Express Calcitonin Receptors in Mouse Bone Marrow Cultures*

1989 • 152 citations

Estradiol stimulates invitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106

1989 • 138 citations

Osteotropic factor responsiveness of highly purified populations of early and late precursors for human multinucleated cells expressing the osteoclast phenotype

1991 • 119 citations

Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells.

1991 • 106 citations

Estrogens in the prevention and treatment of postmenopausal osteoporosis: a review

1988 • 84 citations

Identification of Osteoclast Precursors in Multilineage Hemopoietic Colonies*

1991 • 81 citations

In vivo effects of human recombinant interleukin 6 on hemopoietic stem and progenitor cells and circulating blood cells in normal mice.

1990 • 64 citations

Bone‐cell changes in estrogen‐induced bone‐mass increase in mice: Dissociation of osteoclasts from bone surfaces

1991 • 49 citations

The effects of interleukin 6 and interleukin 3 on early hematopoietic events in long-term cultures of human marrow.

1991 • 47 citations

Comparison of bone and parathyroid hormone as stimulators of osteoclast development and activity in calvarial cell cultures from normal and osteopetrotic (mi/mi) mice

1990 • 23 citations

Leukocytosis in mice following long-term reconstitution with genetically-modified bone marrow cells constitutively expressing interleukin 1α or interleukin 6

1991 • 16 citations