Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation*

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

1995 • 1,661 citations

In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria.

1983 • 1,661 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Cytokine signal transduction

1994 • 1,358 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Osteonal and hemi‐osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone

1994 • 968 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Jaks and Stats in signaling by the cytokine receptor superfamily

1995 • 902 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

1995 • 583 citations

Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

1993 • 507 citations

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

1995 • 423 citations

The alphas, betas, and kinases of cytokine receptor complexes

1993 • 418 citations

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.

1995 • 396 citations

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

1995 • 395 citations

Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression.

1989 • 372 citations

Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors

1994 • 359 citations

Production of mRNA in chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences

1979 • 326 citations

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

1989 • 280 citations

Interleukin-6 prevents dexamethasone-induced myeloma cell death

1994 • 275 citations

Effects of combining transforming growth factor beta and 1,25-dihydroxyvitamin D3 on differentiation of a human osteosarcoma (MG-63).

1992 • 185 citations

Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3.

1995 • 180 citations

Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells.

1996 • 171 citations

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

1990 • 155 citations

OSTEOBLASTIC CELL LINEAGE

1993 • 149 citations

Osteoblasts display receptors for and responses to leukemia‐inhibitory factor

1990 • 134 citations

The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage*

1997 • 125 citations

Developmental Abnormalities in Mice Transgenic for Bovine Oncostatin M

1995 • 120 citations

Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells.

1994 • 105 citations

In Vitro Cultivation of Human Tumor Tissues II. Morphological and Virological Characterization of Three Cell Lines

1978 • 105 citations

Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3.

1993 • 101 citations

1,25-Dihydroxyvitamin D3 increases bone alkaline phosphatase isoenzyme levels in human osteogenic sarcoma cells.

1983 • 86 citations

Soluble interleukin‐6 receptor (sIL‐6R), a new prognostic factor in multiple myeloma

1996 • 82 citations

Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.

1991 • 77 citations

Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.

1991 • 76 citations

Interleukin-6-type cytokines.

1995 • 76 citations

Regulation of Prostaglandin Endoperoxide H Synthase 1 and 2 by Estradiol and Progesterone in Nonpregnant Ovine Myometrium and Endometriumin Vivo¹

1997 • 75 citations

Leukemia Inhibitory Factor Suppresses Proliferation, Alkaline Phosphatase Activity, and Type I Collagen Messenger Ribonucleic Acid Level and Enhances Osteopontin mRNA Level in Murine Osteoblast-Like (MC3T3E1) Cells

1990 • 68 citations

Leukemia Inhibitory Factor Binds with High Affinity to Preosteoblastic RCT-1 Cells and Potentiates the Retinoic Acid Induction of Alkaline Phosphatase

1990 • 58 citations

Cells of BoneOsteoclast Generation

2002 • 45 citations

Regulation of osteoblast proliferation by leukemia inhibitory factor

1991 • 38 citations

Parathyroid hormone-stimulated development of osteoclasts in cultures of cells from neonatal murine calvaria

1986 • 34 citations

Recombinant Human Leukemia Inhibitory Factor Is Mitogenic for Human Bone-Derived Osteoblast-like Cells

1994 • 18 citations