The Death of Osteocytes via Apoptosis Accompanies Estrogen Withdrawal in Human Bone*

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β

1996 • 799 citations

Sensitivity of osteocytes to biomechanical stress in vitro

1995 • 768 citations

Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.

1994 • 697 citations

An improved automated procedure for the determination of calcium in biological specimens

1967 • 585 citations

Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone

1996 • 427 citations

Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability.

1996 • 420 citations

Journal of Bone and Mineral Research

1992 • 359 citations

Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling?

1995 • 332 citations

Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis.

1995 • 273 citations

Osteocyte density changes in aging and osteoporosis

1996 • 250 citations

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

1995 • 240 citations

Identification of apoptotic changes in osteocytes in normal and pathological human bone

1997 • 231 citations

In Vivo Osteocyte Death

1960 • 190 citations

Perspectives: Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption

1991 • 133 citations

Experimental Osteonecrosis of the Femoral Head in Adult Rabbits

1978 • 120 citations

In vitro evaluation of estrogenic, estrogen antagonistic and progestagenic effects of a steroidal drug (Org OD-14) and its metabolites on human endometrium

1990 • 116 citations

Cortical and trabecular bone mineral content in women with endometriosis: effect of gonadotropin-releasing hormone agonist and danazol

1989 • 113 citations

Preliminary in situ identification of estrogen target cells in bone

1995 • 110 citations

Bone age, mineral density, and fatigue damage

1993 • 107 citations

Osteocyte death and hip fracture

1993 • 96 citations

The effects of gonadotrophin-releasing hormone agonists on iliac crest cancellous bone structure in women with endometriosis

1995 • 94 citations

Cell proliferation and enzyme activities associated with the development of avian tibial dyschondroplasia: An in situ biochemical study

1992 • 74 citations

Bone death in hip fracture in the elderly

1990 • 61 citations

The Pathogenesis of Osteoarthritis of the Hip

1987 • 53 citations

Isolated chick osteocytes stimulate formation and bone-resorbing activity of osteoclast-like cells

1995 • 43 citations

Regulation of apoptosis by low serum in cells of different stages of neoplastic progression: enhanced susceptibility after loss of a senescence gene and decreased susceptibility after loss of a tumor suppressor gene.

1994 • 42 citations

In situ nick-translation detects focal apoptosis in thymuses of glucocorticoid- and lipopolysaccharide-treated mice.

1994 • 41 citations

Goserelin

1996 • 39 citations

Human cranial bone structure and the healing of cranial bone grafts: a study using backscattered electron imaging and confocal microscopy

1990 • 39 citations

Chick osteocyte-derived protein inhibits osteoclastic bone resorption

1997 • 33 citations

Fluctuation of mineral apposition rate at individual bone-remodeling sites in human iliac cancellous bone: Independent correlations with osteoid width and osteoblastic alkaline phosphatase activity

1994 • 28 citations