Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein

2014 • 5,592 citations

Galanin — a novel biologically active peptide from porcine intestine

1983 • 1,480 citations

Intracellular ATP directly blocks K+ channels in pancreatic B-cells

1984 • 1,199 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

1984 • 1,099 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Regulation of insulin release by calcium.

1981 • 866 citations

FORMATION OF A CYCLIC ADENINE RIBONUCLEOTIDE BY TISSUE PARTICLES

1958 • 802 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

The Biochemistry of Desferrioxamine and its Relation to Iron Metabolism

1964 • 620 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.

1987 • 452 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

Fluoroaluminates activate transducin‐GDP by mimicking the γ‐phosphate of GTP in its binding site

1985 • 420 citations

Glucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP

1985 • 388 citations

Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

1987 • 383 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

Role of a guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4,5-bisphosphate by calcium-mobilizing hormones and the control of cell calcium. Studies utilizing aluminum fluoride.

1985 • 290 citations

A metabolite-regulated potassium channel in rat pancreatic B cells.

1986 • 277 citations

Electrophysiology of the pancreas.

1987 • 259 citations

Direct G protein gating of ion channels

1988 • 258 citations

The ATP‐sensitivity of K⁺ channels in rat pancreatic B‐cells is modulated by ADP

1986 • 242 citations

Regulation of immunoreactive-insulin release from a rat cell line (RINm5F)

1983 • 240 citations

Intracellular ADP activates K⁺ channels that are inhibited by ATP in an insulin‐secreting cell line

1986 • 227 citations

Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line.

1984 • 199 citations

Reconstitution of Somatostatin and Muscarinic Receptor Mediated Stimulation of K⁺Channels by Isolated G_KProtein in Clonal Rat Anterior Pituitary Cell Membranes *

1987 • 188 citations

Galanin: a novel pancreatic neuropeptide

1986 • 181 citations

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

1988 • 173 citations

A single GTP-binding protein regulates K+-channels coupled with dopamine, histamine and acetylcholine receptors

1987 • 161 citations

Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells.

1986 • 149 citations

ATP-sensitive inward rectifier and voltage- and calcium-activated K+ channels in cultured pancreatic islet cells

1985 • 144 citations

Angiotensin II-induced stimulation of voltage-dependent Ca2+ currents in an adrenal cortical cell line.

1988 • 134 citations

GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels.

1988 • 134 citations

Interaction of diazoxide, tolbutamide and ATP4− on nucleotide-dependent K+ channels in an insulin-secreting cell line

1987 • 132 citations

Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors

1979 • 129 citations

Mechanism of galanin-inhibited insulin release. Occurrence of a pertussis-toxin-sensitive inhibition of adenylate cyclase

1988 • 126 citations

The antidiabetic sulfonylurea glibenclamide is a potent blocker of the ATP-modulated K+ channel in insulin secreting cells

1987 • 117 citations

Activators of protein kinase C depolarize insulin-secreting cells by closing K+ channels.

1988 • 105 citations

Islet cyclic AMP levels are not lowered during alpha 2-adrenergic inhibition of insulin release.

1984 • 105 citations

Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F)

1983 • 103 citations

Signal Transduction in Insulin Secretion:.

1986 • 96 citations

Single calcium-dependent cation channels in mouse pancreatic acinar cells

1984 • 88 citations

The gating of nucleotide-sensitive K+ channels in insulin-secreting cells can be modulated by changes in the ratio ATP4−/ADP3− and by nonhydrolyzable derivatives of both ATP and ADP

1988 • 81 citations

Galanin inhibits glucose-stimulated insulin release by a mechanism involving hyperpolarization and lowering of cytoplasmic free Ca2+ concentration

1986 • 75 citations

AlF4- reversibly inhibits ‘P’-type cation-transport ATPases, possibly by interacting with the phosphate-binding site of the ATPase

1988 • 70 citations

ATP-sensitive K+ channels in an insulin-secreting cell line are inhibited byd-glyceraldehyde and activated by membrane permeabilization

1986 • 65 citations

GTP and GDP activation of K+ channels that can be inhibited by ATP

1986 • 59 citations

Galanin and the endocrine pancreas

1988 • 58 citations

Effects of pyridine nucleotides on the gating of ATP-sensitive potassium channels in insulin-secreting cells

1988 • 55 citations

Activation of polyphosphoinositide phospholipase C by fluoride in WRK1 cell membranes

1986 • 49 citations

Photoreceptor GTP binding protein mediates fluoride activation of phosphodiesterase.

1985 • 33 citations

Effects of Galanin on Insulin Responses to Hormonal, Neuropeptidal, and Pharmacological Stimuli in Conscious Dogs*

1988 • 15 citations