Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Regulation of insulin release by calcium.

1981 • 866 citations

Protein kinase C activation by diacylglycerol second messengers

1986 • 498 citations

Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.

1986 • 491 citations

Analysis of lipids and lipoproteins

1975 • 416 citations

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1984 • 410 citations

Metabolism of Molecular Species of Diacylglycerophospholipids

1978 • 331 citations

Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells

1984 • 324 citations

Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II.

1985 • 304 citations

Corticotropin-(1–24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain

1981 • 287 citations

Insulin secretion: Combined effects of phorbol ester and A23187

1983 • 250 citations

Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

1987 • 244 citations

Glucose metabolism in mouse pancreatic islets

1970 • 235 citations

Quantitation and early kinetics of inositol lipid changes induced by vasopressin in isolated and cultured hepatocytes.

1983 • 232 citations

Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine.

1987 • 157 citations

Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells.

1986 • 149 citations

Nutrient and Hormone-Neurotransmitter Stimuli Induce Hydrolysis of Polyphosphoinositides in Rat Pancreatic Islets*

1984 • 106 citations

Calcium‐activated, phospholipid‐dependent protein kinase in rat pancreas islets of langerhans

1982 • 99 citations

Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans

1983 • 98 citations

Signal Transduction in Insulin Secretion:.

1986 • 96 citations

The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids

1975 • 95 citations

Glucose-induced phospholipid hydrolysis in isolated pancreatic islets: quantitative effects on the phospholipid content of arachidonate and other fatty acids

1986 • 90 citations

The fatty acid composition of phosphatidylinositol, phosphatidate and 1,2-diacylglycerol in stimulated human neutrophils

1984 • 80 citations

Pancreatic islets synthesize phospholipids de novo from glucose via acyl-dihydroxyacetone phosphate

1985 • 76 citations

Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism

1986 • 72 citations

Studies on the role of inositol trisphosphate in the regulation of insulin secretion from isolated rat islets of Langerhans

1985 • 62 citations

A transient increase in diacylglycerols is associated with the action of vasopressin on hepatocytes

1984 • 53 citations

Stimulation of protein kinase C and insulin release by 1-oleoyl-2-acetyl-glycerol

1985 • 52 citations

Metabolic concomitants in pure, pancreatic beta cells during glucose-stimulated insulin secretion.

1986 • 50 citations

Activity of endogenous phospholipase C and phospholipase A2 in glucose stimulated pancreatic islets

1984 • 49 citations

Secretin induces rapid increases in inositol trisphosphate, cytosolic Ca2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini

1986 • 48 citations

Rapid Glucose-Dependent Increases in Phosphatidic Acid and Phosphoinositides in Rat Pancreatic Islets*

1986 • 44 citations

Phorbol ester stimulation of insulin release and secretory-granule protein phosphorylation in a transplantable rat insulinoma

1984 • 44 citations

Muscarinic-agonist and guanine nucleotide activation of polyphosphoinositide phosphodiesterase in isolated islet-cell membranes

1986 • 42 citations

The role of calcium in phospholipid turnover following glucose stimulation in neonatal rat cultured islets.

1984 • 40 citations

Effects of cholinergic stimulation on levels and fatty acid composition of diacylglycerols in mouse pancreas

1981 • 40 citations

A comparison of the effects of glucose and acetylcholine on insulin release and intermediary metabolism in rat pancreatic islets.

1979 • 37 citations

Enhanced de novo synthesis of phosphatidic acid and phosphatidylinositol in rat pancreatic islets exposed to nutrient or neurotransmitter stimuli

1984 • 33 citations

Use of [1-14C]acetic anhydride to quantitate diglycerides: A new analytical procedure

1974 • 32 citations

Glucose-induced phospholipid-dependent protein phosphorylation in neonatal rat islets

1986 • 31 citations

Insulinotropic effects of exogenous phospholipase A2 and C in isolated pancreatic islets

1982 • 30 citations

Stimulus-secretion coupling of glucose-induced insulin release. Timing of early metabolic, ionic, and secretory events

1981 • 23 citations

Production of inositol trisphosphates and inositol tetrakisphosphate in stimulated pancreatic islets

1987 • 22 citations

Presence of membrane‐associated phosphatidate phosphohydrolase activity in cultured islets and its stimulation by glucose

1985 • 20 citations

Glucose Metabolism of Pancreatic Islets Isolated from Neonatal Rats

1972 • 19 citations

Phosphoinositide phosphorylation and hydrolysis in pancreatic islet cell membrane

1986 • 18 citations

Interactions of Ca2+, Mg2+, and Na+ in regulation of insulin release from rat islets

1983 • 7 citations