Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator.

1982 • 2,255 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

Regulation of insulin release by calcium.

1981 • 866 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths

1985 • 660 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands

1985 • 450 citations

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1984 • 410 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Lymphocyte membrane potential assessed with fluorescent probes

1980 • 336 citations

Inositol trisphosphates in carbachol-stimulated rat parotid glands

1984 • 296 citations

Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells

1985 • 234 citations

Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli

1984 • 224 citations

Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line.

1984 • 199 citations

Relationship between secretagogue-induced Ca2+ release and inositol polyphosphate production in permeabilized pancreatic acinar cells.

1985 • 184 citations

Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells

1984 • 184 citations

Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cells

1982 • 182 citations

Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

1985 • 167 citations

Direct enhancement of insulin secretion by vagal stimulation of the isolated pancreas

1973 • 113 citations

Nutrient and Hormone-Neurotransmitter Stimuli Induce Hydrolysis of Polyphosphoinositides in Rat Pancreatic Islets*

1984 • 106 citations

The effect of inositol trisphosphate on Ca2+ fluxes in insulin-secreting tumor cells.

1984 • 104 citations

Cytosolic free Ca2+ in insulin secreting cells and its regulation by isolated organelles

1984 • 95 citations

The enzymology of stimulated inositol lipid turnover

1982 • 77 citations

Muscarinic receptor-induced phosphoinositide hydrolysis at resting cytosolic Ca2+ concentration in PC12 cells.

1985 • 76 citations

Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells.

1984 • 72 citations

Structure-Function Relationship of Calcium Ion Channel Antagonists at the Pituitary Gonadotrope^*

1983 • 71 citations

Studies on the role of inositol trisphosphate in the regulation of insulin secretion from isolated rat islets of Langerhans

1985 • 62 citations

Glyceraldehyde, but not cyclic AMP‐stimulated insulin release is preceded by a rise in cytosolic free Ca²⁺

1984 • 55 citations

Studies of the cholinergic receptors involved in the secretion of insulin using isolated perfused rat pancreas

1973 • 51 citations

Dependency of Acetylcholine-Induced Insulin Release on Ca⁺⁺Uptake by Rat Pancreatic Islets*

1980 • 42 citations

Distinct effects of acetylcholine and glucose on ⁴⁵calcium and ⁸⁶rubidium efflux from mouse pancreatic islets

1984 • 39 citations

A comparison of the effects of glucose and acetylcholine on insulin release and intermediary metabolism in rat pancreatic islets.

1979 • 37 citations

Phosphatidylinositol hydrolysis in isolated guinea-pig islets of Langerhans

1983 • 34 citations

Extracellular Calcium and Acetylcholine-stimulated Insulin Secretion

1974 • 17 citations

Extracellular calcium and adrenergic and cholinergic effects on islet beta-cell function

1976 • 16 citations