Features of Gene Structure, Organization, and Expression That Are Providing Unique Insights into Molecular Evolution and Systematics

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Evolution by Gene Duplication

1970 • 6,000 citations

Evolution by gene duplication

1970 • 5,849 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1977 • 3,829 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Evolutionary Divergence and Convergence in Proteins

1965 • 2,780 citations

A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase

1975 • 2,622 citations

Why genes in pieces?

1978 • 2,256 citations

The use of thin acrylamide gels for DNA sequencing

1978 • 1,449 citations

The structure and evolution of the human β-globin gene family

1980 • 1,398 citations

Evolving Genes and Proteins

1965 • 1,314 citations

High-Efficiency Cloning of Full-Length cDNA

1982 • 1,309 citations

Are snRNPs involved in splicing?

1980 • 1,206 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

Capping of eucaryotic mRNAs

1976 • 1,141 citations

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

1978 • 1,117 citations

Estimation of evolutionary distances between homologous nucleotide sequences.

1981 • 1,076 citations

Promoter Sequences of Eukaryotic Protein-Coding Genes

1980 • 971 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

Evolving Genes and Proteins

1965 • 802 citations

High-efficiency cloning of full-length cDNA.

1982 • 763 citations

The evolution of genes: the chicken preproinsulin gene

1980 • 725 citations

Speculations on RNA splicing

1981 • 639 citations

Compact form of DNA induced by spermidine

1976 • 561 citations

A mechanism for RNA splicing.

1980 • 553 citations

Sequence of the human insulin gene

1980 • 553 citations

Rapid duplication and loss of genes coding for the alpha chains of hemoglobin.

1980 • 531 citations

Pseudogenes as a paradigm of neutral evolution

1981 • 526 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

The structure and evolution of the two nonallelic rat preproinsulin genes

1979 • 500 citations

Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron

1980 • 477 citations

Molecular Mechanisms of Protein Biosynthesis

1977 • 472 citations

Human growth hormone DNA sequence and mRNA structure: possible alternative splicing

1981 • 464 citations

THE ORGANIZATION, EXPRESSION, AND EVOLUTION OF ANTIBODY GENES AND OTHER MULTIGENE FAMILIES

1975 • 446 citations

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.

1978 • 419 citations

A single mouse α-amylase gene specifies two different tissue-specific mRNAs

1981 • 402 citations

Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I.

1978 • 395 citations

Correlation of DNA exonic regions with protein structural units in haemoglobin

1981 • 394 citations

Histone Genes and Histone Messengers

1979 • 373 citations

The primary transcription unit of the mouse β-Major globin gene

1981 • 358 citations

RNA Processing and the Intervening Sequence Problem

1979 • 353 citations

The evolution and sequence comparison of two recently diverged mouse chromosomal β-globin genes

1979 • 337 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

The complete sequence of a chromosomal mouse α-globin gene reveals elements conserved throughout vertebrate evolution

1979 • 317 citations

Darwinian evolution in the genealogy of haemoglobin

1975 • 306 citations

The Structure and Evolution of the Human /?-Globin Gene Family

1980 • 301 citations

Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

1981 • 298 citations

A pseudogene structure in 5S DNA of Xenopus laevis

1977 • 296 citations

Complete amino acid sequence of β₂-microglobulin

1973 • 283 citations

Synthesis of full length cDNAs from four partially purified oviduct mRNAs.

1978 • 279 citations

Exons encode functional and structural units of chicken lysozyme.

1980 • 273 citations

The structure of a human α-globin pseudogene and its relationship to α-globin gene duplication

1980 • 259 citations

Sequence at the 3′ end of globin mRNA shows homology with immunoglobulin light chain mRNA

1974 • 256 citations

Comparison of Total Sequence of a Cloned Rabbit β-Globin Gene and Its Flanking Regions with a Homologous Mouse Sequence

1979 • 256 citations

Covalent structure of human haptoglobin: a serine protease homolog.

1980 • 244 citations

A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences.

1981 • 243 citations

β+ Thalassemia: Aberrant splicing results from a single point mutation in an intron

1981 • 235 citations

Structure and in Vitro Transcription of Human Globin Genes

1980 • 231 citations

Specific in vitro initiation of transcription on conalbumin and ovalbumin genes and comparison with adenovirus-2 early and late genes

1980 • 217 citations

Cellular and molecular regulation of hemoglobin switching

1980 • 209 citations

Initiation of Protein Synthesis at an Unusual Position in an Immunoglobulin Gene?

1972 • 204 citations

Recent developments in the molecular genetics of human hemoglobin

1979 • 199 citations

Unusual alpha-globin-like gene that has cleanly lost both globin intervening sequences.

1980 • 196 citations

The primary structure of the human ε-globin gene

1980 • 195 citations

Phylogenetic origins and adaptive evolution of avian and mammalian haemoglobin genes

1982 • 194 citations

Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart.

1977 • 193 citations

Linkage of adult α- and β-globin genes in X. laevis and gene duplication by tetraploidization

1980 • 188 citations

The primary sequence of rabbit α-globin mRNA

1978 • 174 citations

Dispersion of α-like globin genes of the mouse to three different chromosomes

1981 • 171 citations

The structure and transcription of four linked rabbit β-like globin genes

1979 • 171 citations

Decoding the pattern of protein evolution

1981 • 168 citations

DNA sequence organization of the β-globin complex in the BALB/c mouse

1980 • 167 citations

A mouse α-globin-related pseudogene lacking intervening sequences

1980 • 162 citations

A novel α-globin gene arrangement in man

1980 • 159 citations

Localization of DNA sequences necessary for transcription of the rabbit β-globin gene in vitro

1981 • 158 citations

Molecular evolution of human and rabbit beta-globin mRNAs.

1977 • 157 citations

Mutation in an intervening sequence splice junction in man.

1981 • 153 citations

Ovomucoid intervening sequences specify functional domains and generate protein polymorphism

1980 • 152 citations

Complete nucleotide sequence of the human δ-globin gene

1980 • 146 citations

Genetic Variation in the Human Insulin Gene

1980 • 145 citations

On the Fidelity of DNA Replication

1979 • 144 citations

Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein.

1981 • 138 citations

Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.

1980 • 136 citations

The structure of a chromosomal leghaemoglobin gene from soybean

1981 • 132 citations

Rapidly evolving mouse alpha-globin-related pseudo gene and its evolutionary history.

1981 • 131 citations

Cloning of cDNA of major antigen of foot and mouth disease virus and expression in E. coli

1981 • 128 citations

The nucleotide sequence of a rabbit β-globin pseudogene

1980 • 118 citations

Mechanism for RNA splicing of gene transcripts

1979 • 114 citations

Alternatives for splicing: Recognizing the ends of introns

1980 • 113 citations

DNA Sequence of Two Closely Linked Human Leukocyte Interferon Genes

1981 • 110 citations

The 3′ untranslated regions of the duplicated human α-globin genes are unexpectedly divergent

1980 • 106 citations

The relationship between coding sequences and function in haemoglobin

1980 • 106 citations

Evolution of the β-globin gene cluster in man and the primates

1981 • 103 citations

Characterization of globin domains: Heme binding to the central exon product

1980 • 100 citations

Structure of genes for human growth hormone and chorionic somatomammotropin.

1979 • 96 citations

Molecular cloning and sequence analysis of adult chicken β globin cDNA

1979 • 95 citations

Mouse globin system: a functional and evolutionary analysis

1980 • 95 citations

Silent Nucleotide Substitutions and the Molecular Evolutionary Clock

1980 • 93 citations

The genetic behaviour of a cloned mouse ribosomal DNA segment mimics mouse ribosomal gene evolution

1979 • 92 citations

Chromosomal arrangement of the chicken β-type globin genes

1981 • 91 citations

Abnormally spliced messenger RNA in erythroid cells from patients with β+ thalassemia and monkey cells expressing a cloned β+-thalassemic gene

1982 • 91 citations

Cellular and molecular regulation of hemoglobin switching

1979 • 91 citations

Isolation and structure of a rat cytochrome c gene.

1981 • 87 citations

Pseudogenes

1980 • 84 citations

One gene, but two messenger RNAs encode liver L and red cell L′ pyruvate kinase subunits

1981 • 80 citations

Growth hormone: deletions in the protein and introns in the gene

1980 • 78 citations

An adenovirus mutant defective in splicing RNA from early region 1A

1981 • 78 citations

Internal organization of the major adult α- and β-globin genes of X. laevis

1980 • 76 citations

Mouse Cμ heavy chain immunoglobulin gene segment contains three intervening sequences separating domains

1980 • 65 citations

Nucleotide sequence of the coding portion of human alpha globin messenger RNA.

1980 • 64 citations

The nucleotide sequence of the rabbit embryonic globin gene beta 4.

1983 • 61 citations

The Ribonucleic Acids

1977 • 52 citations

The sequence of a mouse embryonic beta-globin gene. Evolution of the gene and its signal region.

1982 • 52 citations

The nucleotide sequence of the major β-globin mRNA from Xenopus laevis

1980 • 51 citations

Isolation and characterization of genomic DNA coding for α2 Type I collagen

1980 • 50 citations

Structural comparisons of heme binding proteins

1979 • 50 citations

Two related pseudogenes are the result of a gene duplication in the goat β-globin locus

1981 • 48 citations

A transcription map for the rabbit β-globin gene

1981 • 47 citations

Complete amino acid sequences of the major early embryonic alpha-like globins of the chicken.

1980 • 47 citations

Split Genes

1981 • 45 citations

Hemoglobin 3α Chains in Apes

1973 • 41 citations

Hemoglobin switching in sheep. Isolation of the fetal gamma-globin gene and demonstration that the fetal gamma- and adult beta A-globin genes lie within eight kilobase segments of homologous DNA.

1981 • 41 citations

Silent delta-globin gene in Old World monkeys.

1980 • 39 citations

Determination of nucleotide sequences in DNA

1981 • 37 citations

Chicken globin genes. Nucleotide sequence of cDNA clones coding for the alpha-globin expressed during hemolytic anemia.

1980 • 34 citations

Molecular cloning of human epsilon-globin gene.

1979 • 32 citations

The isolation of the beta A-, beta C-, and gamma-globin genes and a presumptive embryonic globin gene from a goat DNA recombinant library.

1980 • 31 citations

Mouse alpha-globin genes and alpha-globin-like pseudogenes are not syntenic.

1981 • 31 citations

Insulin-related growth factors

1978 • 30 citations

Determination of Nucleotide Sequences in DNA

2004 • 30 citations

THE EVOLUTIONARY RELATIONSHIPS OF THE ENZYMES INVOLVED IN BLOOD COAGULATION AND HEMOSTASIS*

1981 • 30 citations

Exons and the structure, function and evolution of haemoglobin

1981 • 30 citations

Primate hemoglobins: Polymorphisms and evolutionary patterns

1972 • 28 citations

Infidelity of DNA synthesis by reverse transcriptase

1973 • 28 citations

Nucleotide Sequences from the Rabbit Beta Globin Gene Inserted into Escherichia coli Plasmids

1977 • 26 citations

Identification by nucleotide sequence analysis of a goat pseudoglobin gene

1980 • 26 citations

Unusual sequence homology at the 5-ends of the developmentally regulated beta A-, beta C-, and gamma-globin genes of the goat.

1980 • 26 citations

Nucleotide sequence analysis of a cloned duck β-globin cDNA

1981 • 23 citations

The nucleotide sequence of rabbit embryonic globin gene beta 3.

1981 • 23 citations

No evidence for ‘stress’ α-globin genes in chicken

1982 • 21 citations

Alternatives for splicing: an intron-coded protein

1980 • 21 citations

Human Globin Messenger RNA: Importance of Cloning for Structural Analysis

1977 • 20 citations

Hemoglobin switching in sheep.

1980 • 18 citations

Properties of the Hemoglobins of Newborn and Adult Prosimians (Prosimii: Lemuriformes and Lorisiformes)

1972 • 13 citations

Isolation of a Xenopus laevis α-globin gene

1981 • 13 citations

Rapid DNA Sequence Analysi

1979 • 10 citations

Messenger RNA and Its Translation

1977 • 10 citations

Current approaches to analysis of the nucleotide sequence of DNA

1979 • 9 citations

α and β Chains of the major haemoglobin and a note on the minor component of Tarsius

1976 • 8 citations

Deleted Work

1955 • 0 citations